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Acute Myeloid Leukemia with Trisomy 8

MedGen UID:
1696774
•Concept ID:
C5206816
•
Neoplastic Process

Definition

An acute myeloid leukemia with trisomy 8. Trisomy 8 is one of the most frequent occurring cytogenetic abnormalities in acute myeloid leukemia. It is grouped as intermediate risk in cytogenetic classifications of acute myeloid leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myeloid Leukemia with Trisomy 8

Professional guidelines

PubMed

Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients.
Xiong T, Xia L, Song Q
J Clin Lab Anal 2023 Feb;37(3):e24835. Epub 2023 Jan 16 doi: 10.1002/jcla.24835. PMID: 36644997Free PMC Article
Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004.
Rasche M, von Neuhoff C, Dworzak M, Bourquin JP, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas OA, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D
Leukemia 2017 Dec;31(12):2807-2814. Epub 2017 Apr 25 doi: 10.1038/leu.2017.121. PMID: 28443606Free PMC Article
Identification of molecular and cytogenetic risk factors for unfavorable core-binding factor-positive adult AML with post-remission treatment outcome analysis including transplantation.
Yoon JH, Kim HJ, Kim JW, Jeon YW, Shin SH, Lee SE, Cho BS, Eom KS, Kim YJ, Lee S, Min CK, Cho SG, Lee JW, Min WS, Park CW
Bone Marrow Transplant 2014 Dec;49(12):1466-74. Epub 2014 Aug 11 doi: 10.1038/bmt.2014.180. PMID: 25111512

Recent clinical studies

Etiology

Optimized cytogenetic risk-group stratification of KMT2A-rearranged pediatric acute myeloid leukemia.
van Weelderen RE, Harrison CJ, Klein K, Jiang Y, Abrahamsson J, Alonzo T, Aplenc R, Arad-Cohen N, Bart-Delabesse E, Buldini B, De Moerloose B, Dworzak MN, Elitzur S, Fernández Navarro JM, Gamis A, Gerbing RB, Goemans BF, de Groot-Kruseman HA, Guest E, Ha SY, Hasle H, Kelaidi C, Lapillonne H, Leverger G, Locatelli F, Miyamura T, Norén-Nyström U, Polychronopoulou S, Rasche M, Rubnitz JE, Stary J, Tierens A, Tomizawa D, Zwaan CM, Kaspers GJL
Blood Adv 2024 Jun 25;8(12):3200-3213. doi: 10.1182/bloodadvances.2023011771. PMID: 38621200Free PMC Article
Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Genetic abnormalities and pathophysiology of MDS.
Hosono N
Int J Clin Oncol 2019 Aug;24(8):885-892. Epub 2019 May 15 doi: 10.1007/s10147-019-01462-6. PMID: 31093808
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Diagnosis

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Autoimmune and inflammatory manifestations associated with acute myeloid leukemia with Trisomy 8-Case series and review of the literature.
Buchrits S, Kozlovoski D, Gafter-Gvili A, Raanani P, Hayman L, Revyako I, Bernstine H, Wolach O, Shimony S
Eur J Haematol 2022 Mar;108(3):199-203. Epub 2021 Dec 21 doi: 10.1111/ejh.13725. PMID: 34748235
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822

Therapy

Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Acute myeloid leukemia and Langerhans' cell histiocytosis: multiple theories for an unusual presentation.
Ghosn MG, Haddad AC, Nassar MN, Abadjian GA, El Karak FR, Aftimos PG
Leuk Res 2010 Mar;34(3):406-8. Epub 2009 Aug 11 doi: 10.1016/j.leukres.2009.07.025. PMID: 19674788
Acute leukemia associated with mediastinal germ cell tumor. De novo versus therapy-related leukemia.
Keung YK, Liang R, Chiu EK
West J Med 1993 Apr;158(4):409-12. PMID: 8391189Free PMC Article
Trisomy 8 in acute myeloblastic leukemia and sideroachrestic anemia.
Jonasson J, Gahrton G, Lindsten J, Simonsson-Lindemalm C, Zech L
Blood 1974 Apr;43(4):557-63. PMID: 4522153

Prognosis

Optimized cytogenetic risk-group stratification of KMT2A-rearranged pediatric acute myeloid leukemia.
van Weelderen RE, Harrison CJ, Klein K, Jiang Y, Abrahamsson J, Alonzo T, Aplenc R, Arad-Cohen N, Bart-Delabesse E, Buldini B, De Moerloose B, Dworzak MN, Elitzur S, Fernández Navarro JM, Gamis A, Gerbing RB, Goemans BF, de Groot-Kruseman HA, Guest E, Ha SY, Hasle H, Kelaidi C, Lapillonne H, Leverger G, Locatelli F, Miyamura T, Norén-Nyström U, Polychronopoulou S, Rasche M, Rubnitz JE, Stary J, Tierens A, Tomizawa D, Zwaan CM, Kaspers GJL
Blood Adv 2024 Jun 25;8(12):3200-3213. doi: 10.1182/bloodadvances.2023011771. PMID: 38621200Free PMC Article
Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Trisomy 8 in acute myeloid leukemia.
Hemsing AL, Hovland R, Tsykunova G, Reikvam H
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 Sep 26 doi: 10.1080/17474086.2019.1657400. PMID: 31422708
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Acute promyelocytic leukemia with trisomy 8 and del(9)(q22) after treatment of cervical cancer with concurrent chemoradiotherapy: a case report.
Kim J, Park TS, Kim JS, Song J, Lee KA, Cho SY, Oh SH, Choi JR
Onkologie 2011;34(7):388-90. Epub 2011 Jun 17 doi: 10.1159/000329612. PMID: 21734427

Clinical prediction guides

Prognosis influence of additional chromosome abnormalities in newly diagnosed acute promyelocytic leukemia with t(15;17)(q24;q21).
Liu L, Wang J, Xu H, Zhao S, Wang L, Huang J, Wang H, Tong H, Jin J
Hematology 2024 Dec;29(1):2293513. Epub 2023 Dec 27 doi: 10.1080/16078454.2023.2293513. PMID: 38149662
Establishment and validation of prognostic nomogram in acute leukemia with trisomy 8.
Deng T, Wang S, Ran Z, Liu Q, Wang M
Hematology 2023 Dec;28(1):2240131. doi: 10.1080/16078454.2023.2240131. PMID: 37545412
Relapse and cytogenetic evolution in myeloid neoplasms.
Ertz-Archambault N, Kelemen K
Panminerva Med 2017 Dec;59(4):308-319. doi: 10.23736/S0031-0808.17.03380-8. PMID: 29144072
Childhood myelodysplastic syndrome.
Chatterjee T, Choudhry VP
Indian J Pediatr 2013 Sep;80(9):764-71. Epub 2013 Aug 3 doi: 10.1007/s12098-013-1130-8. PMID: 23912822
Trisomy 14 and leukemia.
Reddy KS
Cancer Genet Cytogenet 1998 Oct 15;106(2):144-51. doi: 10.1016/s0165-4608(98)00053-3. PMID: 9797780

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