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Recurrent Acute Erythroid Leukemia

MedGen UID:
1669222
•Concept ID:
C4745019
•
Neoplastic Process
Synonym: Relapsed Acute Erythroid Leukemia

Definition

The reemergence of acute erythroid leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Erythroid Leukemia

Professional guidelines

PubMed

A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria.
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082
Treatment with recombinant interferon (alpha-2b) early after bone marrow transplantation in patients at high risk for relapse [corrected].
Klingemann HG, Grigg AP, Wilkie-Boyd K, Barnett MJ, Eaves AC, Reece DE, Shepherd JD, Phillips GL
Blood 1991 Dec 15;78(12):3306-11. PMID: 1742491
Daunorubicin-prednisone treatment of erythroleukemia.
Bloomfield CD, Brunning RD, Kennedy BJ
Ann Intern Med 1974 Dec;81(6):746-50. doi: 10.7326/0003-4819-81-6-746. PMID: 4530645

Recent clinical studies

Etiology

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
Del (9q) AML: clinical and cytological characteristics and prognostic implications.
Peniket A, Wainscoat J, Side L, Daly S, Kusec R, Buck G, Wheatley K, Walker H, Chatters S, Harrison C, Boultwood J, Goldstone A, Burnett A
Br J Haematol 2005 Apr;129(2):210-20. doi: 10.1111/j.1365-2141.2005.05445.x. PMID: 15813849

Diagnosis

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria.
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Erythroleukemia relapsing as precursor B-cell lymphoblastic leukemia.
Park BG, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH
Korean J Lab Med 2011 Apr;31(2):81-5. doi: 10.3343/kjlm.2011.31.2.81. PMID: 21474980Free PMC Article

Therapy

Integrating RNA-seq and scRNA-seq to explore the biological significance of NAD + metabolism-related genes in the initial diagnosis and relapse of childhood B-cell acute lymphoblastic leukemia.
Lin C, Xu JQ, Zhong GC, Chen H, Xue HM, Yang M, Chen C
Front Immunol 2022;13:1043111. Epub 2022 Nov 11 doi: 10.3389/fimmu.2022.1043111. PMID: 36439178Free PMC Article
Recurrent transcriptional responses in AML and MDS patients treated with decitabine.
Upadhyay P, Beales J, Shah NM, Gruszczynska A, Miller CA, Petti AA, Ramakrishnan SM, Link DC, Ley TJ, Welch JS
Exp Hematol 2022 Jul;111:50-65. Epub 2022 Apr 13 doi: 10.1016/j.exphem.2022.04.002. PMID: 35429619Free PMC Article
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Therapy-related myeloid neoplasms.
Czader M, Orazi A
Am J Clin Pathol 2009 Sep;132(3):410-25. doi: 10.1309/AJCPD85MCOHHCOMQ. PMID: 19687318
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736

Prognosis

Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia.
Villa-Morales M, Pérez-Gómez L, Pérez-Gómez E, López-Nieva P, Fernández-Navarro P, Santos J
Int J Mol Sci 2023 Jun 19;24(12) doi: 10.3390/ijms241210350. PMID: 37373496Free PMC Article
Genomic subtyping and therapeutic targeting of acute erythroleukemia.
Iacobucci I, Wen J, Meggendorfer M, Choi JK, Shi L, Pounds SB, Carmichael CL, Masih KE, Morris SM, Lindsley RC, Janke LJ, Alexander TB, Song G, Qu C, Li Y, Payne-Turner D, Tomizawa D, Kiyokawa N, Valentine M, Valentine V, Basso G, Locatelli F, Enemark EJ, Kham SKY, Yeoh AEJ, Ma X, Zhou X, Sioson E, Rusch M, Ries RE, Stieglitz E, Hunger SP, Wei AH, To LB, Lewis ID, D'Andrea RJ, Kile BT, Brown AL, Scott HS, Hahn CN, Marlton P, Pei D, Cheng C, Loh ML, Ebert BL, Meshinchi S, Haferlach T, Mullighan CG
Nat Genet 2019 Apr;51(4):694-704. Epub 2019 Mar 29 doi: 10.1038/s41588-019-0375-1. PMID: 30926971Free PMC Article
Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.
Moyo TK, Savona MR
Curr Hematol Malig Rep 2016 Dec;11(6):441-448. doi: 10.1007/s11899-016-0356-8. PMID: 27734261
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
Del (9q) AML: clinical and cytological characteristics and prognostic implications.
Peniket A, Wainscoat J, Side L, Daly S, Kusec R, Buck G, Wheatley K, Walker H, Chatters S, Harrison C, Boultwood J, Goldstone A, Burnett A
Br J Haematol 2005 Apr;129(2):210-20. doi: 10.1111/j.1365-2141.2005.05445.x. PMID: 15813849

Clinical prediction guides

A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia.
Li R, Wu Y, Zhang X, Wang L, Zhang Y, Xiao H
Clin Lab 2023 Apr 1;69(4) doi: 10.7754/Clin.Lab.2022.220723. PMID: 37057942
A reevaluation of erythroid predominance in Acute Myeloid Leukemia using the updated WHO 2016 Criteria.
Margolskee E, Mikita G, Rea B, Bagg A, Zuo Z, Sun Y, Goswami M, Wang SA, Oak J, Arber DA, Allen MB, George TI, Rogers HJ, Hsi E, Hasserjian RP, Orazi A
Mod Pathol 2018 Jun;31(6):873-880. Epub 2018 Feb 5 doi: 10.1038/s41379-018-0001-2. PMID: 29403082
Exome sequencing identifies highly recurrent somatic GATA2 and CEBPA mutations in acute erythroid leukemia.
Ping N, Sun A, Song Y, Wang Q, Yin J, Cheng W, Xu Y, Wen L, Yao H, Ma L, Qiu H, Ruan C, Wu D, Chen S
Leukemia 2017 Jan;31(1):195-202. Epub 2016 Jun 15 doi: 10.1038/leu.2016.162. PMID: 27389056
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736

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