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Acute monoblastic leukemia

MedGen UID:
141597
Concept ID:
C0457334
Neoplastic Process
Synonyms: Acute Monoblastic Leukemia; Acute Monoblastic Leukemia (FAB M5a); FAB M5A; FAB type M5a; French-American-British type M5a
SNOMED CT: French-American-British type M5a (278170009); FAB M5A (22331004); FAB type M5a (278170009)

Definition

An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population. (WHO, 2001) [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Lampkin BC, Lange B, Bernstein I, Woods W, Odom L, Wells R, Ruymann F, Feig S, Miller L, Chard R
Pediatr Clin North Am 1988 Aug;35(4):743-64. doi: 10.1016/s0031-3955(16)36508-7. PMID: 3047652
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Recent clinical studies

Etiology

Lackner H, Seidel MG, Strenger V, Sovinz P, Schwinger W, Benesch M, Sperl D, Urban C
Support Care Cancer 2013 Dec;21(12):3519-23. Epub 2013 Aug 24 doi: 10.1007/s00520-013-1937-x. PMID: 23975227
Thayu M, Baltimore RS, Sleight BJ, Reyes-Mugica M, Hotez PJ
Pediatr Infect Dis J 1999 Apr;18(4):397-8. doi: 10.1097/00006454-199904000-00025. PMID: 10223705
Odom LF, Lampkin BC, Tannous R, Buckley JD, Hammond GD
Leuk Res 1990;14(1):1-10. doi: 10.1016/0145-2126(90)90140-5. PMID: 2406511
Weil M, Jacquillat C, Tobelem G
Haematol Blood Transfus 1981;27:189-194. doi: 10.1007/978-3-642-81696-3_21. PMID: 6948758
Tobelem G, Jacquillat C, Chastang C, Auclerc MF, Lechevallier T, Weil M, Daniel MT, Flandrin G, Harrousseau JL, Schaison G, Boiron M, Bernard J
Blood 1980 Jan;55(1):71-6. PMID: 6927957

Diagnosis

Sánchez CM, de Castro DR, de Viñaspre AVG, Zilaurren AU, Abad AM, de Castro JMG
Turk J Haematol 2020 Nov 19;37(4):282-283. Epub 2020 Jun 10 doi: 10.4274/tjh.galenos.2020.2020.0237. PMID: 32519830Free PMC Article
Gnanasekaran KK, Chacko MP, Manipadam MT, Bindra MS, George B, Srivastava VM
Indian J Pathol Microbiol 2016 Jan-Mar;59(1):104-6. doi: 10.4103/0377-4929.174829. PMID: 26960652
Rallis E, Stavropoulou E, Michalakeas I, Papadakis P, Poziopoulos C
Am J Hematol 2009 Sep;84(9):590-1. doi: 10.1002/ajh.21326. PMID: 19051330
Psiachou-Leonard E, Paterakis G, Stefanaki K, Mikraki-Christou V, Haidas S
Leuk Res 2001 Nov;25(11):1019-21. doi: 10.1016/s0145-2126(01)00068-6. PMID: 11597737
Raney RB Jr, Mohanakumar T, Metzgar RS, Hann HW, Buck BE, Donaldson MH
Leuk Res 1980;4(1):61-7. doi: 10.1016/0145-2126(80)90046-6. PMID: 6931956

Therapy

Brierley CK, Eyre TA
Blood 2017 Jun 22;129(25):3396. doi: 10.1182/blood-2017-03-765776. PMID: 28642361
Pawarode A, Baer MR, Padmanabhan S, Wallace PK, Barcos M, Sait SN, Block AW, Wetzler M, Battiwalla M
Leuk Lymphoma 2005 Dec;46(12):1813-8. doi: 10.1080/10428190500244258. PMID: 16263586
McCollum A, Bigelow CL, Elkins SL, Hardy CL, Files JC
South Med J 2003 Jul;96(7):681-4. doi: 10.1097/01.SMJ.0000054224.50737.4C. PMID: 12940320
Mangal AK, Grossman L, Vickars L
Can Med Assoc J 1984 Mar 15;130(6):731-3. PMID: 6582992Free PMC Article
Weil M, Jacquillat C, Tobelem G
Haematol Blood Transfus 1981;27:189-194. doi: 10.1007/978-3-642-81696-3_21. PMID: 6948758

Prognosis

Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Gnanasekaran KK, Chacko MP, Manipadam MT, Bindra MS, George B, Srivastava VM
Indian J Pathol Microbiol 2016 Jan-Mar;59(1):104-6. doi: 10.4103/0377-4929.174829. PMID: 26960652
Rallis E, Stavropoulou E, Michalakeas I, Papadakis P, Poziopoulos C
Am J Hematol 2009 Sep;84(9):590-1. doi: 10.1002/ajh.21326. PMID: 19051330
Jakab Z, Szegedi I, Balogh E, Kiss C, Oláh E
Med Pediatr Oncol 2002 Jul;39(1):66-8. doi: 10.1002/mpo.10043. PMID: 12116087
Psiachou-Leonard E, Paterakis G, Stefanaki K, Mikraki-Christou V, Haidas S
Leuk Res 2001 Nov;25(11):1019-21. doi: 10.1016/s0145-2126(01)00068-6. PMID: 11597737

Clinical prediction guides

Douet-Guilbert N, Morel F, Le Bris MJ, Sassolas B, Giroux JD, De Braekeleer M
Leuk Lymphoma 2005 Jan;46(1):143-6. doi: 10.1080/104281904000010783. PMID: 15621793
Murati A, Adélaïde J, Popovici C, Mozziconacci MJ, Arnoulet C, Lafage-Pochitaloff M, Sainty D, Birnbaum D, Chaffanet M
Int J Mol Med 2003 Oct;12(4):423-8. PMID: 12964013
Van Limbergen H, Poppe B, Janssens A, De Bock R, De Paepe A, Noens L, Speleman F
Leukemia 2002 Mar;16(3):344-51. doi: 10.1038/sj.leu.2402397. PMID: 11896537
Pernice F, Musolino C, Mazza G, Puglisi D, Squadrito G, Frisina N, Squadrito G
Cancer Genet Cytogenet 1998 Mar;101(2):152-5. doi: 10.1016/s0165-4608(97)00264-1. PMID: 9494619
Sainati L, Bolcato S, Cocito MG, Zanesco L, Basso G, Montaldi A, Piovesan AL
Pediatr Hematol Oncol 1996 Mar-Apr;13(2):151-7. doi: 10.3109/08880019609030805. PMID: 8721029

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