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Benign Female Breast Neoplasm

MedGen UID:
116011
•Concept ID:
C0235922
•
Neoplastic Process
Synonyms: Benign Female Breast Tumor; Benign Neoplasm of Female Breast; Benign Neoplasm of the Female Breast; Benign Tumor of Female Breast; Benign Tumor of the Female Breast

Definition

A neoplasm that arises from the breast in females and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Female Breast Neoplasm

Professional guidelines

PubMed

Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel.
Parsons MT, de la Hoya M, Richardson ME, Tudini E, Anderson M, Berkofsky-Fessler W, Caputo SM, Chan RC, Cline MS, Feng BJ, Fortuno C, Gomez-Garcia E, Hadler J, Hiraki S, Holdren M, Houdayer C, Hruska K, James P, Karam R, Leong HS, Martins A, Mensenkamp AR, Monteiro AN, Nathan V, O'Connor R, Pedersen IS, Pesaran T, Radice P, Schmidt G, Southey M, Tavtigian S, Thompson BA, Toland AE, Turnbull C, Vogel MJ, Weyandt J, Wiggins GAR, Zec L, Couch FJ, Walker LC, Vreeswijk MPG, Goldgar DE, Spurdle AB
Am J Hum Genet 2024 Sep 5;111(9):2044-2058. Epub 2024 Aug 13 doi: 10.1016/j.ajhg.2024.07.013. PMID: 39142283Free PMC Article
Idiopathic Granulomatous Mastitis: Etiology, Clinical Manifestation, Diagnosis and Treatment.
Yin Y, Liu X, Meng Q, Han X, Zhang H, Lv Y
J Invest Surg 2022 Mar;35(3):709-720. Epub 2021 Mar 10 doi: 10.1080/08941939.2021.1894516. PMID: 33691563
Radiomics Improves Cancer Screening and Early Detection.
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666

Recent clinical studies

Etiology

Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Is Breast Implant-Associated Anaplastic Large Cell Lymphoma Better Classified as a Lymphoproliferative Disorder and How Surgeons Reduce Risk?
Lukavsky RJ, Couto RA, Adams WP Jr
Clin Plast Surg 2021 Jan;48(1):71-77. Epub 2020 Oct 9 doi: 10.1016/j.cps.2020.08.002. PMID: 33220906
Phyllodes tumour of the breast and margins: How much is enough.
Ogunbiyi S, Perry A, Jakate K, Simpson J, George R
Can J Surg 2019 Feb 1;62(1):E19-E21. doi: 10.1503/cjs.005718. PMID: 30694037Free PMC Article
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Fibroadenoma.
Dent DM, Cant PJ
World J Surg 1989 Nov-Dec;13(6):706-10. doi: 10.1007/BF01658418. PMID: 2696223

Diagnosis

Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Phyllodes tumours.
Parker SJ, Harries SA
Postgrad Med J 2001 Jul;77(909):428-35. doi: 10.1136/pmj.77.909.428. PMID: 11423590Free PMC Article
MR imaging of the breast: current status and future potential.
Harms SE, Flamig DP, Evans WP, Harries SA, Brown S
AJR Am J Roentgenol 1994 Nov;163(5):1039-47. doi: 10.2214/ajr.163.5.7976873. PMID: 7976873
Fibroadenoma.
Dent DM, Cant PJ
World J Surg 1989 Nov-Dec;13(6):706-10. doi: 10.1007/BF01658418. PMID: 2696223

Therapy

Contrast-Enhanced Mammography-Guided Breast Biopsy: Single-Center Experience.
Kornecki A, Bhaduri M, Khan N, Nachum IB, Muscedere G, Shmuilovich O, Lynn K, Nano E, Blyth L
AJR Am J Roentgenol 2023 Jun;220(6):826-827. Epub 2023 Feb 1 doi: 10.2214/AJR.22.28780. PMID: 36722757
Management of Stromal Lesions.
Yu J, Kansal K
Surg Clin North Am 2022 Dec;102(6):1017-1030. doi: 10.1016/j.suc.2022.07.002. PMID: 36335922
Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.
Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW
Sex Med Rev 2019 Jan;7(1):84-94. Epub 2018 Nov 30 doi: 10.1016/j.sxmr.2018.09.006. PMID: 30503797Free PMC Article
Breast cancer screening in young women.
Desreux JAC
Eur J Obstet Gynecol Reprod Biol 2018 Nov;230:208-211. Epub 2018 May 24 doi: 10.1016/j.ejogrb.2018.05.018. PMID: 29804884
Ablative techniques in the treatment of benign and malignant breast disease.
Simmons RM
J Am Coll Surg 2003 Aug;197(2):334-8. doi: 10.1016/S1072-7515(03)00385-5. PMID: 12892821

Prognosis

SMARCE1 is required for the invasive progression of in situ cancers.
Sokol ES, Feng YX, Jin DX, Tizabi MD, Miller DH, Cohen MA, Sanduja S, Reinhardt F, Pandey J, Superville DA, Jaenisch R, Gupta PB
Proc Natl Acad Sci U S A 2017 Apr 18;114(16):4153-4158. Epub 2017 Apr 4 doi: 10.1073/pnas.1703931114. PMID: 28377514Free PMC Article
Profile of breast lesions among women with positive biopsy findings in Yemen.
Al-Thobhani AK, Raja'a YA, Noman TA, Al-Romaimah MA
East Mediterr Health J 2006 Sep;12(5):599-604. PMID: 17333799
Phyllodes tumours.
Parker SJ, Harries SA
Postgrad Med J 2001 Jul;77(909):428-35. doi: 10.1136/pmj.77.909.428. PMID: 11423590Free PMC Article
Fibroadenoma of the breast: a follow-up of conservative management.
Wilkinson S, Anderson TJ, Rifkind E, Chetty U, Forrest AP
Br J Surg 1989 Apr;76(4):390-1. doi: 10.1002/bjs.1800760424. PMID: 2720350
Cystosarcoma phyllodes.
McCrea ES, Johnston C, Keramati B
South Med J 1986 May;79(5):543-7. doi: 10.1097/00007611-198605000-00007. PMID: 3010475

Clinical prediction guides

The dilemma of recalling well-circumscribed masses in a screening population: A narrative literature review and exploration of Dutch screening practice.
Geertse TD, van der Waal D, Vreuls W, Tetteroo E, Duijm LEM, Pijnappel RM, Broeders MJM
Breast 2023 Jun;69:431-440. Epub 2023 May 3 doi: 10.1016/j.breast.2023.05.001. PMID: 37169601Free PMC Article
Breast fibroadenomas: a review in the light of current literature.
Salati SA
Pol Przegl Chir 2020 Dec 7;93(1):40-48. doi: 10.5604/01.3001.0014.5676. PMID: 33729177
Real-time detection of breast cancer at the cellular level.
Carver GE, Locknar SA, Weaver DL, Stein JL, Stein GS
J Cell Physiol 2019 May;234(5):5413-5419. Epub 2018 Oct 26 doi: 10.1002/jcp.27451. PMID: 30362286Free PMC Article
Vascular lesions of the breast.
Baker GM, Schnitt SJ
Semin Diagn Pathol 2017 Sep;34(5):410-419. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.013. PMID: 28676174
MR imaging of the breast: current status and future potential.
Harms SE, Flamig DP, Evans WP, Harries SA, Brown S
AJR Am J Roentgenol 1994 Nov;163(5):1039-47. doi: 10.2214/ajr.163.5.7976873. PMID: 7976873

Recent systematic reviews

Malignant upgrade rate and associated clinicopathologic predictors for concordant intraductal papilloma without atypia: A systematic review and meta-analysis.
Keating N, Cevik J, Hopkins D, Lippey J
J Surg Oncol 2024 May;129(6):1025-1033. Epub 2024 Feb 2 doi: 10.1002/jso.27592. PMID: 38305061
Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.
Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344
Contrast-enhanced Mammography versus Contrast-enhanced Breast MRI: A Systematic Review and Meta-Analysis.
Pötsch N, Vatteroni G, Clauser P, Helbich TH, Baltzer PAT
Radiology 2022 Oct;305(1):94-103. Epub 2022 Jun 7 doi: 10.1148/radiol.212530. PMID: 36154284
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Progestin and breast cancer risk: a systematic review.
Samson M, Porter N, Orekoya O, Hebert JR, Adams SA, Bennett CL, Steck SE
Breast Cancer Res Treat 2016 Jan;155(1):3-12. Epub 2015 Dec 23 doi: 10.1007/s10549-015-3663-1. PMID: 26700034Free PMC Article

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