SMO2-1 sterol 4-alpha-methyl-oxidase 2-1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SMO2-1
Official Full Name: sterol 4-alpha-methyl-oxidase 2-1
Primary source: TAIR:AT1G07420
Locus tag: AT1G07420
See related: Araport:AT1G07420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thaliana sterol 4-alpha-methyl oxidase 1; ATSMO1; ATSMO2; F22G5.23; F22G5_23; STEROL 4-ALPHA-METHYL-OXIDASE 2; sterol 4-alpha-methyl-oxidase 2-1
Summary: Arabidopsis thaliana sterol 4-alpha-methyl-oxidase mRNA
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Genomic context

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See SMO2-1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 7

Sequence:: Chromosome: 1; NC_003070.9 (2277555..2280502)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SMO2-1 is important for correct sterol composition and function partially through effects on auxin accumulation, auxin response to regulate Arabidopsis embryogenesis and postembryonic development.
Title: Sterol Methyl Oxidases Affect Embryo Development via Auxin-Associated Mechanisms.
SMO2 is a functional homologue of Saccharomyces cerevisiae TRM112, and disruption of SMO2 mainly inhibits the G2-M phase progression during organogenesis.
Title: The Arabidopsis SMO2, a homologue of yeast TRM112, modulates progression of cell division during organ growth.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_100616.3

Supported by ESTs:

NM_202048.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within 4-alpha-methyl-delta7-sterol oxidation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast envelope	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sterol 4-alpha-methyl-oxidase 2-1

NP_563789.1

sterol 4-alpha-methyl-oxidase 2-1 (SMO2-1); FUNCTIONS IN: C-4 methylsterol oxidase activity, 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity; INVOLVED IN: oxidation reduction, fatty acid biosynthetic process; LOCATED IN: chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-2 (TAIR:AT2G29390.2); Has 2893 Blast hits to 2888 proteins in 513 species: Archae - 0; Bacteria - 699; Metazoa - 429; Fungi - 685; Plants - 484; Viruses - 3; Other Eukaryotes - 593 (source: NCBI BLink).

NP_973777.1

sterol 4-alpha-methyl-oxidase 2-1 (SMO2-1); FUNCTIONS IN: C-4 methylsterol oxidase activity, 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity; INVOLVED IN: oxidation reduction, fatty acid biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-2 (TAIR:AT2G29390.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

2277555..2280502

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100616.3 → NP_563789.1 sterol 4-alpha-methyl-oxidase 2-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFL5, Q8LBE1, Q8VWZ8, Q9LNW2

UniProtKB/TrEMBL

A0A178WAJ4, A0A5S9T3A5, A0A5S9X2F0

Conserved Domains (1) summary

pfam04116
Location:112 → 247

FA_hydroxylase; Fatty acid hydroxylase superfamily
NM_202048.2 → NP_973777.1 sterol 4-alpha-methyl-oxidase 2-1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973777.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8VWZ8

Conserved Domains (2) summary

COG3000
Location:34 → 209

ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]

pfam04116
Location:74 → 209

FA_hydroxylase; Fatty acid hydroxylase superfamily