Arhgap40 Rho GTPase activating protein 40 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap40provided by MGI
Official Full Name: Rho GTPase activating protein 40provided by MGI
Primary source: MGI:MGI:3649852
See related: Ensembl:ENSMUSG00000074625 AllianceGenome:MGI:3649852
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm14203; C20orf95
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of actin filament polymerization and regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Is expressed in testis. Orthologous to human ARHGAP40 (Rho GTPase activating protein 40). [provided by Alliance of Genome Resources, Feb 2025]
Expression: Biased expression in bladder adult (RPKM 8.5), mammary gland adult (RPKM 4.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 78.72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (158354682..158392786)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (158512796..158550628)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit409 (e-PCR), detects polymorphism
- UniSTS:129315

AI507211 (e-PCR)
- UniSTS:165228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho GTPase-activating protein 40

Names: rho-type GTPase-activating protein 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145015.2 → NP_001138487.1 rho GTPase-activating protein 40

See identical proteins and their annotated locations for NP_001138487.1

Status: VALIDATED

Source sequence(s)

AL663091

Consensus CDS

CCDS50787.1

UniProtKB/Swiss-Prot

A2ACC5, E9Q6X9

UniProtKB/TrEMBL

A0A0A0MQB4

Related

ENSMUSP00000096736.5, ENSMUST00000099133.11

Conserved Domains (1) summary

cl02570
Location:318 → 530

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...