U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thoc6 THO complex 6 [ Mus musculus (house mouse) ]

Gene ID: 386612, updated on 8-Mar-2025

Summary

Go to the top of the page Help
Official Symbol
Thoc6provided by MGI
Official Full Name
THO complex 6provided by MGI
Primary source
MGI:MGI:2677480
See related
Ensembl:ENSMUSG00000041319 AllianceGenome:MGI:2677480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr58; F830014G06Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in central nervous system development and mRNA export from nucleus. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC6 (THO complex subunit 6). [provided by Alliance of Genome Resources, Mar 2025]
Expression
Ubiquitous expression in thymus adult (RPKM 19.7), CNS E11.5 (RPKM 13.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Thoc6 in Genome Data Viewer
Location:
17 A3.3; 17 11.97 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23887592..23892891, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23668618..23673917, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene BICD family like cargo adaptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E8656 Neighboring gene host cell factor C1 regulator 1 (XPO1-dependent) Neighboring gene tumor necrosis factor receptor superfamily, member 12a Neighboring gene claudin 6

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Bhattacharjee R, et al. Nat Commun, 2024 Feb 8. PMID 38331934, Free PMC Article
  2. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Wang L, et al. Cell Stem Cell, 2013 Dec 5. PMID 24315442, Free PMC Article
  3. TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Werren EA, et al. Nat Commun, 2024 Feb 22. PMID 38388531, Free PMC Article
  4. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Sánchez C, et al. Mol Cell Proteomics, 2007 May. PMID 17296600
  5. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC107304, MGC109691

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
THO complex subunit 6 homolog
Names
WD repeat domain 58
WD repeat-containing protein 58

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008425.2 → NP_001008425.1  THO complex subunit 6 homolog

    See identical proteins and their annotated locations for NP_001008425.1

    Status: VALIDATED

    Source sequence(s)
    AC154766, AI850888, BC085131, CX224561
    Consensus CDS
    CCDS28454.1
    UniProtKB/Swiss-Prot
    Q5U4D9
    UniProtKB/TrEMBL
    D3Z132
    Related
    ENSMUSP00000038137.5, ENSMUST00000047436.11
    Conserved Domains (2) summary
    sd00039
    Location:28 → 74
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:31 → 196
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001357380.1 → NP_001344309.1  THO complex subunit 6 homolog

    Status: VALIDATED

    Source sequence(s)
    AC154766, AI850888, BC085131, CO428739
    Consensus CDS
    CCDS28454.1
    UniProtKB/Swiss-Prot
    Q5U4D9
    UniProtKB/TrEMBL
    D3Z132
    Related
    ENSMUSP00000093239.5, ENSMUST00000095579.11
    Conserved Domains (2) summary
    sd00039
    Location:28 → 74
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:31 → 196
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23887592..23892891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249886.1 → XP_030105746.1  THO complex subunit 6 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5U4D9
    UniProtKB/TrEMBL
    D3Z132
    Related
    ENSMUSP00000111153.3, ENSMUST00000115490.9
    Conserved Domains (2) summary
    sd00039
    Location:28 → 74
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:31 → 196
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4D9.1 GenPept UniProtKB/Swiss-Prot:Q5U4D9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous