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SCARA5 scavenger receptor class A member 5 [ Homo sapiens (human) ]

Gene ID: 286133, updated on 8-Mar-2025

Summary

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Official Symbol
SCARA5provided by HGNC
Official Full Name
scavenger receptor class A member 5provided by HGNC
Primary source
HGNC:HGNC:28701
See related
Ensembl:ENSG00000168079 MIM:611306; AllianceGenome:HGNC:28701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tesr; NET33
Summary
Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within cellular response to heat. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Broad expression in fat (RPKM 25.7), colon (RPKM 18.6) and 19 other tissues See more
Orthologs
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Genomic context

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See SCARA5 in Genome Data Viewer
Location:
8p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27869883..27992673, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (28147213..28270893, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27727400..27850190, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene MPRA-validated peak6971 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27158 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene PDZ binding kinase Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27735141-27735642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27750341-27750927 Neighboring gene VISTA enhancer hs1741 Neighboring gene uncharacterized LOC105379342 Neighboring gene microRNA 4287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27806885-27807386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27807387-27807886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27834121-27835005 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27918038-27918203 Neighboring gene nuclear GTPase, germinal center associated Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27920879-27921378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27160 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27950237-27950790 Neighboring gene MPRA-validated peak6972 silencer Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene uncharacterized LOC105379343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma. Jiang X, et al. Epigenomics, 2023 Jun. PMID 37554122
  2. Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition. Zheng C, et al. Cell Biochem Funct, 2020 Mar. PMID 31989658, Free PMC Article
  3. The scavenger receptor SCARA5 is an endocytic receptor for von Willebrand factor expressed by littoral cells in the human spleen. Swystun LL, et al. J Thromb Haemost, 2019 Aug. PMID 31126000, Free PMC Article
  4. Downregulation of SCARA5 may contribute to breast cancer via promoter hypermethylation. Ulker D, et al. Gene, 2018 Oct 5. PMID 29908284
  5. Identification of SCARA5 as a Potential Biomarker for Oral Squamous Cell Carcinoma using MALDI-TOF-MS Analysis. Liu Y, et al. Proteomics Clin Appl, 2018 Sep. PMID 29461673

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCARA5 as a downstream factor of PCAT29, inhibits proliferation, migration, and invasion of bladder cancer.
    Title: SCARA5 as a downstream factor of PCAT29, inhibits proliferation, migration, and invasion of bladder cancer.
  2. m[6]A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.
    Title: m(6)A-mediated upregulation of lncRNA RMRP boosts the progression of bladder cancer via epigenetically suppressing SCARA5.
  3. Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma.
    Title: Methylated tumor suppressor gene SCARA5 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma.
  4. SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain.
    Title: SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain.
  5. Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.
    Title: Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.
  6. Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.
    Title: Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway.
  7. SCARA5 is a Novel Biomarker in Colorectal Cancer by Comprehensive Analysis.
    Title: SCARA5 is a Novel Biomarker in Colorectal Cancer by Comprehensive Analysis.
  8. SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway.
    Title: SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K/AKT pathway.
  9. Interactions of ferritin with scavenger receptor class A members.
    Title: Interactions of ferritin with scavenger receptor class A members.
  10. Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition.
    Title: Scavenger receptor class A, member 5 is associated with thyroid cancer cell lines progression via epithelial-mesenchymal transition.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23907, MGC45780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ferritin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in iron ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homotrimerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
scavenger receptor class A member 5
Names
scavenger receptor class A, member 5 (putative)
scavenger receptor hlg
testis expressed scavenger receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413201.1 → NP_001400130.1  scavenger receptor class A member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC069113, AC104997

  2. NM_001413202.1 → NP_001400131.1  scavenger receptor class A member 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC069113
    Related
    ENSP00000428663.1, ENST00000524352.5

  3. NM_001413203.1 → NP_001400132.1  scavenger receptor class A member 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC069113, AC104997
    UniProtKB/TrEMBL
    B4DVB2

  4. NM_173833.6 → NP_776194.2  scavenger receptor class A member 5 isoform 1

    See identical proteins and their annotated locations for NP_776194.2

    Status: VALIDATED

    Source sequence(s)
    AC069113, AC104997
    Consensus CDS
    CCDS6064.1
    UniProtKB/Swiss-Prot
    Q6UXZ1, Q6ZMJ2, Q7Z4A1, Q8N4Z7
    Related
    ENSP00000346990.3, ENST00000354914.8
    Conserved Domains (3) summary
    smart00202
    Location:393 → 493
    SR; Scavenger receptor Cys-rich
    pfam01391
    Location:318 → 373
    Collagen; Collagen triple helix repeat (20 copies)
    pfam12795
    Location:89 → 191
    MscS_porin; Mechanosensitive ion channel porin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27869883..27992673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    28147213..28270893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMJ2.1 GenPept UniProtKB/Swiss-Prot:Q6ZMJ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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