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HMGN2P46 high mobility group nucleosomal binding domain 2 pseudogene 46 [ Homo sapiens (human) ]

Gene ID: 283651, updated on 8-Mar-2025

Summary

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Official Symbol
HMGN2P46provided by HGNC
Official Full Name
high mobility group nucleosomal binding domain 2 pseudogene 46provided by HGNC
Primary source
HGNC:HGNC:26817
See related
MIM:611314; AllianceGenome:HGNC:26817
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D-PCa-2; C15orf21
Summary
Predicted to enable chromatin binding activity. Predicted to be involved in chromatin organization. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Expression
Biased expression in prostate (RPKM 16.7), testis (RPKM 1.2) and 1 other tissue See more
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Genomic context

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See HMGN2P46 in Genome Data Viewer
Location:
15q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (45511136..45556730)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (43319297..43364888)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (45803334..45848928)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45741730-45742660 Neighboring gene uncharacterized LOC124903483 Neighboring gene SLC30A4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45746566-45747066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9361 Neighboring gene NANOG hESC enhancer GRCh37_chr15:45751227-45751805 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:45764241-45764930 Neighboring gene solute carrier family 30 member 4 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6410 Neighboring gene small nucleolar RNA, H/ACA box 41B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45839047-45839548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:45839549-45840048 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:45840653-45841852 Neighboring gene developmental pluripotency associated 5 pseudogene 2 Neighboring gene MPRA-validated peak2326 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9363 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:45880103-45880723 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. A new RNA-seq method to detect the transcription and non-coding RNA in prostate cancer. Zhang XM, et al. Pathol Oncol Res, 2014 Jan. PMID 24043589
  2. D-PCa-2: a novel transcript highly overexpressed in human prostate and prostate cancer. Weigle B, et al. Int J Cancer, 2004 May 10. PMID 15027122
  3. Retroposed copies of the HMG genes: a window to genome dynamics. Strichman-Almashanu LZ, et al. Genome Res, 2003 May. PMID 12727900, Free PMC Article
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • Dresden prostate cancer 2
  • Dresden prostate carcinoma 2

Clone Names

  • FLJ39426

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_022014.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK096745, AY271964

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    45511136..45556730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    43319297..43364888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001005266.1: Suppressed sequence

    Description
    NM_001005266.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NM_001005267.1: Suppressed sequence

    Description
    NM_001005267.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  3. NM_001005268.1: Suppressed sequence

    Description
    NM_001005268.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  4. NM_001005269.1: Suppressed sequence

    Description
    NM_001005269.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  5. NM_173609.2: Suppressed sequence

    Description
    NM_173609.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
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