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LOC130000459 ATAC-STARR-seq lymphoblastoid active region 27423 [ Homo sapiens (human) ]

Gene ID: 130000459, updated on 12-Sep-2024

Summary

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Gene symbol
LOC130000459
Gene description
ATAC-STARR-seq lymphoblastoid active region 27423
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC130000459 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (60518231..60518420)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (60942009..60942198)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (61430790..61430979)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27422 Neighboring gene long intergenic non-protein coding RNA 1301 Neighboring gene Sharpr-MPRA regulatory region 15457 Neighboring gene uncharacterized LOC124901949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:61428694-61429554 Neighboring gene RAB2A, member RAS oncogene family Neighboring gene uncharacterized LOC124901950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19225 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:61563068-61563273 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:61564220-61564720 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27425 Neighboring gene chromodomain helicase DNA binding protein 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:61693034-61694233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27427 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_179905.1 

    Range
    101..290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    60518231..60518420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    60942009..60942198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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