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LOC127889346 OCT4-NANOG hESC enhancer GRCh37_chr18:49595452-49596115 [ Homo sapiens (human) ]

Gene ID: 127889346, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127889346
Gene description
OCT4-NANOG hESC enhancer GRCh37_chr18:49595452-49596115
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Dec 2022]
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Genomic context

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See LOC127889346 in Genome Data Viewer
Location:
chromosome: 18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (52069082..52069745)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (52272066..52272729)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (49595452..49596115)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 57 homolog (Chlamydomonas) pseudogene Neighboring gene VISTA enhancer hs1726 Neighboring gene NANOG hESC enhancer GRCh37_chr18:49472122-49472636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13337 Neighboring gene NANOG hESC enhancer GRCh37_chr18:49514627-49515128 Neighboring gene ribosomal protein S8 pseudogene 3 Neighboring gene VISTA enhancer hs1384 Neighboring gene uncharacterized LOC105372121 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:49754501-49755047 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:49850127-49850638 Neighboring gene vomeronasal 1 receptor 76 pseudogene Neighboring gene DCC netrin 1 receptor Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:50162292-50163491 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47967 Neighboring gene NANOG hESC enhancer GRCh37_chr18:50208549-50209050 Neighboring gene NANOG hESC enhancer GRCh37_chr18:50334126-50334627 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:50582336-50582939 Neighboring gene microRNA 4528

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_138879.1 

    Range
    101..764
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    52069082..52069745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    52272066..52272729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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