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LOC127824020 H3K27ac hESC enhancers GRCh37_chr12:46120332-46121294 and GRCh37_chr12:46121295-46122257 [ Homo sapiens (human) ]

Gene ID: 127824020, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127824020
Gene description
H3K27ac hESC enhancers GRCh37_chr12:46120332-46121294 and GRCh37_chr12:46121295-46122257
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes two enhancers that were validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in human embryonic stem cells, where they are marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, Jun 2023]
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Genomic context

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See LOC127824020 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (45726549..45728474)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (45685177..45687102)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (46120332..46122257)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369743 Neighboring gene uncharacterized LOC124903092 Neighboring gene uncharacterized LOC105369744 Neighboring gene Sharpr-MPRA regulatory region 8796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4374 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:46090484-46090652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4375 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4376 Neighboring gene long intergenic non-protein coding RNA 938 Neighboring gene NANOG hESC enhancer GRCh37_chr12:46161969-46162913 Neighboring gene AT-rich interaction domain 2 Neighboring gene uncharacterized LOC105369745 Neighboring gene MPRA-validated peak1713 silencer Neighboring gene RNA, 7SL, cytoplasmic 246, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 6228
  • H3K27ac hESC enhancer GRCh37_chr12:46120332-46121294
  • H3K27ac hESC enhancer GRCh37_chr12:46121295-46122257

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_125540.2 

    Range
    101..2026
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    45726549..45728474
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    45685177..45687102
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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