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LOC127820173 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2422141-2422641 [ Homo sapiens (human) ]

Gene ID: 127820173, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127820173
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2422141-2422641
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127820173 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (2400911..2401411)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (2490262..2490762)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2422141..2422641)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD81 antisense RNA 1 Neighboring gene uncharacterized LOC105376520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2396527-2397285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2400391-2401372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2401373-2402355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4298 Neighboring gene nonconserved acetylation island sequence 93 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4301 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2421638-2422140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2435338-2435838 Neighboring gene Sharpr-MPRA regulatory region 9407 Neighboring gene CD81 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3070 Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene transient receptor potential cation channel subfamily M member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2482166-2482666 Neighboring gene Sharpr-MPRA regulatory region 11059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4304 Neighboring gene potassium voltage-gated channel subfamily Q member 1 Neighboring gene uncharacterized LOC124902613

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_121638.1 

    Range
    101..601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    2400911..2401411
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    2490262..2490762
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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