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LOC127408277 NANOG-H3K27ac hESC enhancer GRCh37_chr7:2573085-2574005 [ Homo sapiens (human) ]

Gene ID: 127408277, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127408277
Gene description
NANOG-H3K27ac hESC enhancer GRCh37_chr7:2573085-2574005
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the NANOG transcription factor and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127408277 in Genome Data Viewer
Location:
chromosome: 7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (2533451..2534371)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (2646915..2647884)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (2573085..2574005)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986759 Neighboring gene nonconserved acetylation island sequence 106 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17874 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2562611-2563123 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2568003-2568977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2568978-2569951 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2570927-2571899 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:2574006-2574925 Neighboring gene microRNA 4648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2575635-2576136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2576137-2576636 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:2586847-2587013 Neighboring gene BRCA1 associated ATM activator 1 Neighboring gene uncharacterized LOC124901849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2595065-2595742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2606477-2607079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2607080-2607681 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:2611286-2612485 Neighboring gene IQ motif containing E Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:2624592-2625163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2649707-2650280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:2650281-2650854 Neighboring gene uncharacterized LOC107986760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_110245.1 

    Range
    101..1021
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    2533451..2534371
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    2646915..2647884
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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