U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127138837 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:1718443-1718962 [ Homo sapiens (human) ]

Gene ID: 127138837, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127138837
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:1718443-1718962
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic element is found within pseudoautosomal region 1 (PAR1) of chromosomes X and Y, where each chromosome contains the same DNA region. It was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127138837 in Genome Data Viewer
Location:
X;Y
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (1649550..1650069)
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (1649550..1650069)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (1448376..1448895)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (1509350..1509864)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1768443..1768962)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1718443..1718962)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 17A Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776191-1776692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776693-1777192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:1747612-1748179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrY:1778143-1778642 Neighboring gene long intergenic non-protein coding RNA 2968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1883833-1884333 Neighboring gene uncharacterized LOC105379413

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 17A Neighboring gene ReSE screen-validated silencer GRCh37_chrX:1727169-1727341 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678358-1678942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:1678943-1679525 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrX:1737403-1738040 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776191-1776692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1776693-1777192 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:1747612-1748179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrY:1778143-1778642 Neighboring gene long intergenic non-protein coding RNA 2968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:1883833-1884333 Neighboring gene uncharacterized LOC105379413

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_088508.1 

    Range
    101..620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    1649550..1650069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    1649550..1650069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    1448376..1448895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    1509350..1509864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases