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LOC126862442 BRD4-independent group 4 enhancer GRCh37_chr16:87870283-87871482 [ Homo sapiens (human) ]

Gene ID: 126862442, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126862442
Gene description
BRD4-independent group 4 enhancer GRCh37_chr16:87870283-87871482
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126862442 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87836677..87837876)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93909388..93910588)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87870283..87871482)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371399 Neighboring gene uncharacterized LOC102724467 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:87806571-87806776 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87811607-87812472 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87812473-87813338 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87813339-87814204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11335 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:87823556-87824755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87837714-87838214 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87839527-87840470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87840471-87841412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87856683-87857676 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87858671-87859662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87861620-87862209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87863388-87863975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87865154-87865742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87867637-87868191 Neighboring gene Sharpr-MPRA regulatory region 5705 Neighboring gene SLC7A5 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87877095-87878022 Neighboring gene solute carrier family 7 member 5 Neighboring gene microRNA 6775 Neighboring gene hESC enhancers GRCh37_chr16:87882980-87883886 and GRCh37_chr16:87883887-87884792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87885699-87886604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87886605-87887512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87887513-87888418 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:87889541-87889729 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87894111-87894868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87895627-87896384 Neighboring gene microRNA 11401 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:87898083-87898663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7842 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:87903871-87905070 Neighboring gene CRISPRi-validated cis-regulatory element chr16.4806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87909600-87910127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87911269-87911910 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:87911911-87912552 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:87912553-87913192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87931441-87932140 Neighboring gene carbonic anhydrase 5A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11343 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11344

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086940.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    87836677..87837876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    93909388..93910588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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