U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC110991260 solute carrier family 6 member 4 gene promoter [ Mus musculus (house mouse) ]

Gene ID: 110991260, updated on 9-Aug-2024

Summary

Go to the top of the page Help
Gene symbol
LOC110991260
Gene description
solute carrier family 6 member 4 gene promoter
Gene type
biological region
Feature type(s)
protein_bind
regulatory: TATA_box, promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366811
Summary
This genomic sequence represents the 5' regulatory region of the solute carrier family 6 member 4 (Slc6a4) gene on chromosome 11. It includes the promoter region, cis-acting activating and repressive elements, and protein-binding sites. This promoter is orthologous to the human SLC6A4 promoter, but the mouse promoter lacks the 5-HTTLPR polymorphic element that has transcriptional regulatory properties in human. This locus also includes a B cell regulatory element that was identified by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and which was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. [provided by RefSeq, Oct 2023]
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC110991260 in Genome Data Viewer
Location:
11 B5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76886988..76889473)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76996162..76998647)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30046 Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene bleomycin hydrolase Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343 Neighboring gene nuclear speckle regulatory protein 1 Neighboring gene predicted gene, 22772

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Serotonin Transporter and Early Life Stress: Translational Perspectives. Houwing DJ, et al. Front Cell Neurosci, 2017. PMID 28491024, Free PMC Article
  2. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. Gong S, et al. J Neurosci, 2007 Sep 12. PMID 17855595, Free PMC Article
  3. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. Hendricks T, et al. J Neurosci, 1999 Dec 1. PMID 10575032, Free PMC Article
  4. Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. Bengel D, et al. Brain Res Mol Brain Res, 1997 Mar. PMID 9073170
  5. Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only. Pagani JH, et al. Genes Brain Behav, 2015 Feb. PMID 25677455, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Other Names

  • 5-HTT 5'-flanking regulatory region
  • SERT promoter
  • STARR-positive B cell enhancer ABC_E7021
  • Slc6a4 5' regulatory region
  • regulatory region 366811

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_055512.1 

    Range
    101..2586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76886988..76889473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Research Materials