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Brca1 BRCA1 DNA repair associated [ Cricetulus griseus (Chinese hamster) ]

Gene ID: 100770724, updated on 8-Mar-2024

Summary

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Gene symbol
Brca1
Gene description
BRCA1 DNA repair associated
See related
Ensembl:ENSCGRG00015028548
Gene type
protein coding
RefSeq status
MODEL
Organism
Cricetulus griseus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
Orthologs
human mouse all
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Genomic context

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See Brca1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
27
Annotation release Status Assembly Chr Location
104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003614078.1 (1144612..1211657, complement)
104 current CriGri-PICRH-1.0 (GCF_003668045.3) 7 NC_048600.1 (114526055..114593477, complement)

NW_003614078.1Genomic Context describing neighboring genes Neighboring gene vesicle amine transport 1 Neighboring gene Rho family GTPase 2 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene uncharacterized LOC118239211 Neighboring gene transmembrane protein 106A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein
Names
Breast cancer type 1 susceptibility protein-like
breast and ovarian cancer susceptibility 1
breast cancer 1, early onset
breast cancer protein 1
breast cancer type 1 susceptibility protein homolog
putative breast cancer type 1 susceptibility protein like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference CriGri_1.0 Primary Assembly

Genomic

  1. NW_003614078.1 Reference CriGri_1.0 Primary Assembly

    Range
    1144612..1211657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007645166.4 → XP_007643356.1  breast cancer type 1 susceptibility protein isoform X3

    See identical proteins and their annotated locations for XP_007643356.1

    UniProtKB/TrEMBL
    G3HM05
    Conserved Domains (4) summary
    smart00292
    Location:1676 → 1760
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1567 → 1642
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:342 → 503
    BRCT_assoc; Serine-rich domain associated with BRCT

  2. XM_007645167.4 → XP_007643357.1  breast cancer type 1 susceptibility protein isoform X3

    See identical proteins and their annotated locations for XP_007643357.1

    UniProtKB/TrEMBL
    G3HM05
    Conserved Domains (4) summary
    smart00292
    Location:1676 → 1760
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1567 → 1642
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:342 → 503
    BRCT_assoc; Serine-rich domain associated with BRCT

  3. XM_007645168.3 → XP_007643358.1  breast cancer type 1 susceptibility protein isoform X3

    See identical proteins and their annotated locations for XP_007643358.1

    UniProtKB/TrEMBL
    G3HM05
    Conserved Domains (4) summary
    smart00292
    Location:1676 → 1760
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1567 → 1642
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:342 → 503
    BRCT_assoc; Serine-rich domain associated with BRCT

  4. XM_007645165.3 → XP_007643355.1  breast cancer type 1 susceptibility protein isoform X2

    Conserved Domains (4) summary
    smart00292
    Location:1684 → 1768
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:31 → 76
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1575 → 1650
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:350 → 511
    BRCT_assoc; Serine-rich domain associated with BRCT

  5. XM_035457254.1 → XP_035313145.1  breast cancer type 1 susceptibility protein isoform X4

    UniProtKB/TrEMBL
    A0A9J7KAE6
    Conserved Domains (4) summary
    cd17721
    Location:1673 → 1770
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1566 → 1662
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:339 → 500
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl17238
    Location:41 → 68
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_007645171.4 → XP_007643361.2  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A8C2M647

  7. XM_027438147.2 → XP_027293948.1  breast cancer type 1 susceptibility protein isoform X5

    UniProtKB/TrEMBL
    A0A9J7JY17
    Conserved Domains (3) summary
    cd16498
    Location:41 → 88
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:604 → 701
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:497 → 593
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  8. XM_007645169.4 → XP_007643359.1  breast cancer type 1 susceptibility protein isoform X3

    See identical proteins and their annotated locations for XP_007643359.1

    UniProtKB/TrEMBL
    G3HM05
    Conserved Domains (4) summary
    smart00292
    Location:1676 → 1760
    BRCT; breast cancer carboxy-terminal domain
    cd00162
    Location:23 → 68
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00533
    Location:1567 → 1642
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:342 → 503
    BRCT_assoc; Serine-rich domain associated with BRCT

RNA

  1. XR_003490331.2 RNA Sequence

Alternate CriGri-PICRH-1.0

Genomic

  1. NC_048600.1 Alternate CriGri-PICRH-1.0

    Range
    114526055..114593477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027428049.2 → XP_027283850.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    G3HM05
    Related
    ENSCGRP00015038193.1, ENSCGRT00015046516.2

  2. XM_027428050.2 → XP_027283851.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    G3HM05
    Related
    ENSCGRP00015038192.1, ENSCGRT00015046515.2

  3. XM_027428051.2 → XP_027283852.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    G3HM05
    Related
    ENSCGRP00015052891.1, ENSCGRT00015048215.1

  4. XM_035448218.1 → XP_035304109.1  breast cancer type 1 susceptibility protein isoform X4

    UniProtKB/TrEMBL
    A0A9J7KAE6
    Conserved Domains (4) summary
    cd17721
    Location:1673 → 1770
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:1566 → 1662
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    pfam12820
    Location:339 → 500
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl17238
    Location:41 → 68
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. XM_027428048.2 → XP_027283849.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A8C2M647
    Related
    ENSCGRP00015038189.2, ENSCGRT00015046511.2

  6. XM_027428053.2 → XP_027283854.2  breast cancer type 1 susceptibility protein isoform X5

    UniProtKB/TrEMBL
    A0A9J7JY17
    Conserved Domains (3) summary
    cd16498
    Location:41 → 88
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17721
    Location:604 → 701
    BRCT_BRCA1_rpt2; second (C-terminal) BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cd17735
    Location:497 → 593
    BRCT_BRCA1_rpt1; first BRCT domain of breast cancer type 1 susceptibility protein (BRCA1) and similar proteins

  7. XM_027428052.2 → XP_027283853.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    G3HM05

RNA

  1. XR_003487416.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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