EAL domains

c-di-GMP-specific phosphodiesterase class I (EAL) domains in various Bacteria

BACTERIA
Acidobacteria
. Acidobacterium capsulatum ATCC 51196 .................. 7 hits
. Candidatus Koribacter versatilis Ellin345 ............. 3 hits
. Candidatus Solibacter usitatus Ellin6076 .............. 1 hit
. Granulicella tundricola MP5ACTX9 ...................... 12 hits
. Terriglobus roseus DSM 18391 .......................... 15 hits
. Terriglobus saanensis SP1PR4 .......................... 12 hits
Aquificae
. Aquifex aeolicus VF5 .................................. 8 hits
. Desulfurobacterium thermolithotrophum DSM 11699 ....... 4 hits
. Hydrogenobacter thermophilus TK-6 ..................... 4 hits
. Hydrogenobaculum sp. Y04AAS1 .......................... 9 hits
. Persephonella marina EX-H1 ............................ 16 hits
. Sulfurihydrogenibium azorense Az-Fu1 .................. 8 hits
. Sulfurihydrogenibium sp. YO3AOP1 ...................... 7 hits
. Thermocrinis albus DSM 14484 .......................... 5 hits
. Thermovibrio ammonificans HB-1 ........................ 6 hits
Bacteroidetes
. Bacteroides vulgatus ATCC 8482 ........................ 0 hits*
. Salinibacter ruber DSM 13855 .......................... 1 hit
Chloroflexi
. Anaerolinea thermophila UNI-1 ......................... 5 hits
. Chloroflexus aggregans DSM 9485 ....................... 3 hits
. Chloroflexus aurantiacus J-10-fl ...................... 3 hits
. Chloroflexus sp. Y-400-fl ............................. 3 hits
. Herpetosiphon aurantiacus ATCC 23779 .................. 3 hits
. Roseiflexus castenholzii DSM 13941 .................... 3 hits
. Roseiflexus sp. RS-1 .................................. 3 hits
. Sphaerobacter thermophilus DSM 20745 .................. 3 hits
. Thermobaculum terrenum ATCC BAA-798 ................... 2 hits
. Thermomicrobium roseum DSM 5159 ....................... 5 hits
Chrysiogenetes
. Desulfurispirillum indicum S5 ......................... 10 hits
Deferribacteres
. Calditerrivibrio nitroreducens DSM 19672 .............. 7 hits
. Deferribacter desulfuricans SSM1 ...................... 6 hits
. Denitrovibrio acetiphilus DSM 12809 ................... 10 hits
. Flexistipes sinusarabici DSM 4947 ..................... 2 hits
Deinococcus-Thermus group
. Deinococcus gobiensis I-0 ............................. 7 hits
. Deinococcus deserti VCD115 ............................ 11 hits
. Deinococcus geothermalis DSM 11300 .................... 0 hits
. Deinococcus maricopensis DSM 21211 .................... 18 hits
. Deinococcus peraridilitoris DSM 19664 ................. 11 hits
. Deinococcus proteolyticus MRP ......................... 7 hits
. Deinococcus radiodurans R1 ............................ 5 hits
. Marinithermus hydrothermalis DSM 14884 ................ 4 hits
. Meiothermus ruber DSM 1279 ............................ 3 hits
. Meiothermus silvanus DSM 9946 ......................... 4 hits
. Oceanithermus profundus DSM 14977 ..................... 4 hits
. Thermus oshimai JL-2 .................................. 1 hit
. Thermus scotoductus SA-01 ............................. 2 hits
. Thermus sp. CCB_US3_UF1 ............................... 2 hits
. Thermus thermophilus HB27 ............................. 2 hits
. Truepera radiovictrix DSM 17093 ....................... 6 hits
Fibrobacteres
. Fibrobacter succinogenes subsp. succinogenes S85 ...... 5 hits
Fusobacteria
. Ilyobacter polytropus DSM 2926 ........................ 10 hits
Gemmatimonadetes
. Gemmatimonas aurantiaca T-27 .......................... 7 hits
Nitrospirae
. Candidatus Nitrospira defluvii ........................ 1 hit
. Leptospirillum ferriphilum ML-04 ...................... 13 hits
. Leptospirillum ferrooxidans C2-3 ...................... 22 hits
. Thermodesulfovibrio yellowstonii DSM 11347 ............ 2 hits
Planctomycetes
. Phycisphaera mikurensis NBRC 102666 ................... 7 hits
. Pirellula staleyi DSM 6068 ............................ 3 hits
. Planctomyces brasiliensis DSM 5305 .................... 1 hits
. Rhodopirellula baltica SH 1 ........................... 3 hits
Spirochaetes
. Borrelia afzelii PKo .................................. 1 hit
. Borrelia bissettii DN127 .............................. 1 hit
. Borrelia burgdorferi B31 .............................. 1 hit
. Borrelia crocidurae str. Achema........................ 1 hit
. Borrelia duttonii Ly .................................. 1 hit
. Borrelia garinii PBi .................................. 1 hit
. Borrelia hermsii DAH .................................. 1 hit
. Borrelia recurrentis A1 ............................... 1 hit
. Borrelia turicatae 91E135 ............................. 1 hit
. Leptospira biflexa strain 'Patoc 1 (Ames)' ............ 10 hits
. Leptospira borgpetersenii serovar Hardjo-bovis L550 ... 4 hits
. Leptospira interrogans serovar Lai str. 56601 ......... 8 hits
. Spirochaeta africana DSM 8902.......................... 11 hits
. Sphaerochaeta globus str. Buddy ....................... 9 hits
. Sphaerochaeta pleomorpha str. Grapes .................. 8 hits
. Spirochaeta caldaria DSM 7334 ......................... 3 hits
. Spirochaeta coccoides DSM 17374 ....................... 0 hits
. Spirochaeta smaragdinae DSM 11293 ..................... 4 hits
. Spirochaeta thermophila DSM 6192 ...................... 7 hits
. Treponema azotonutricium ZAS-9 ........................ 0 hits
. Treponema brennaborense DSM 12168 ..................... 6 hits
. Treponema denticola ATCC 35405 ........................ 2 hits
. Treponema succinifaciens DSM 2489 ..................... 4 hits
. Turneriella parva DSM 21527............................ 13 hits
Tenericutes
. Acholeplasma laidlawii PG-8A .......................... 5 hits
Thermodesulfobacteria
. Thermodesulfatator indicus DSM 15286 .................. 1 hit
. Thermodesulfobacterium sp. OPB45 ...................... 4 hits
Thermotogae
. Fervidobacterium pennivorans DSM 9078 ................. 1 hit
. Fervidobacterium nodosum Rt17-B1 ...................... 1 hit
. Mesotoga prima MesG1.Ag.4.2 ........................... 1 hit
. Petrotoga mobilis SJ95 ................................ 1 hit
. Thermosipho africanus TCF52B .......................... 1 hit
. Thermosipho melanesiensis BI429 ....................... 1 hit
. Thermotoga lettingae TMO .............................. 1 hit
ARCHAEA
. Acidianus hospitalis W1 ............................... 0 hits*
. Picrophilus torridus DSM 9790 ......................... 0 hits*

Acidobacteria
Acidobacterium capsulatum ATCC 51196
GGDEF-EAL
ACP_0177 ACO34339 PAS domain S-box/GGDEF/EA... BLink CDD UniProt Pfam InterPro
ACP_0756 ACO34432 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
ACP_0922 ACO33442 bacterial signalling prot... BLink CDD UniProt Pfam InterPro
EAL only
ACP_0164 ACO34238 EAL domain protein [Acido... BLink CDD UniProt Pfam InterPro
ACP_0098 ACO33141 PAS domain S-box [Acidoba... BLink CDD UniProt Pfam InterPro
ACP_2081 ACO31374 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro
ACP_0703 ACO33957 EAL domain/histidine kina... BLink CDD UniProt Pfam InterPro

Candidatus Koribacter versatilis Ellin345
EAL only
Acid345_2398 ABF41399 periplasmic sensor digu... BLink CDD UniProt Pfam InterPro
Acid345_0347 ABF39352 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro
Acid345_2882 ABF41883 unnamed protein product... BLink CDD UniProt Pfam InterPro

Candidatus Solibacter usitatus Ellin6076
Acid_4927 ABJ85886 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Granulicella tundricola
GGDEF-EAL
AciX9_0042 ADW67133 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
AciX9_0459 ADW67531 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
AciX9_0474 ADW67546 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
AciX9_0868 ADW67936 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
AciX9_4235 ADW71011 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
AciX9_4297 ADW71065 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
AciX9_0491 ADW67563 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
AciX9_0609 ADW67680 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
AciX9_1797 ADW68845 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
AciX9_1997 ADW69042 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
AciX9_4380 ADW71332 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
AciX9_4648 ADW71578 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Terriglobus roseus DSM 18391
GGDEF-EAL
Terro_0048 AFL86400 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_0084 AFL86435 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_0156 AFL86507 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_2871 AFL89106 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_3151 AFL89380 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_3531 AFL89745 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_3537 AFL89751 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Terro_3895 AFL90104 diguanylate cyclase [Ter... BLink CDD UniProt Pfam InterPro
EAL only
Terro_0787 AFL87119 PAS domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_1816 AFL88109 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_1920 AFL88210 PAS domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_3510 AFL89724 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_3511 AFL89725 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_3517 AFL89731 PAS domain-containing pr... BLink CDD UniProt Pfam InterPro
Terro_3532 AFL89746 putative signal transduc... BLink CDD UniProt Pfam InterPro

Terriglobus saanensis SP1PR4
GGDEF-EAL
AciPR4_0211 ADV81049 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
AciPR4_0310 ADV81147 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
AciPR4_0465 ADV81300 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
AciPR4_0617 ADV81451 response regulator rece... BLink CDD UniProt Pfam InterPro
AciPR4_2084 ADV82888 response regulator rece... BLink CDD UniProt Pfam InterPro
AciPR4_2086 ADV82890 response regulator rece... BLink CDD UniProt Pfam InterPro
AciPR4_3354 ADV84108 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
AciPR4_3653 ADV84405 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
EAL only
AciPR4_0803 ADV81636 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro
AciPR4_3192 ADV83948 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro
AciPR4_3353 ADV84107 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro
AciPR4_3388 ADV84142 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro

Aquificae
Aquifex aeolicus VF5
GGDEF-EAL
AQ_027 AAC06414 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_367 AAC06656 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_1151 AAC07191 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_1442 AAC07394 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
EAL only
AQ_083 AAC06454 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_341 AAC06635 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_478 AAC06749 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro
AQ_2044 AAC07799 hypothetical protein [Aqu... BLink CDD UniProt Pfam InterPro

Desulfurobacterium thermolithotrophum DSM 11699
GGDEF-EAL
Dester_0505 ADY73157 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
Dester_0528 ADY73179 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
EAL only
Dester_0031 ADY72691 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro
Dester_1475 ADY74103 diguanylate phosphodies... BLink CDD UniProt Pfam InterPro

Hydrogenobacter thermophilus TK-6
GGDEF-EAL
HTH_0927 ADO45320 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
HTH_0036 BAI68503 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
HTH_0219 BAI68686 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
HTH_0370 BAI68836 hypothetical protein HTH_... BLink CDD UniProt Pfam InterPro

Hydrogenobaculum sp. Y04AAS1
GGDEF-EAL
HY04AAS1_0140 ACG56832 diguanylate cyclase [... BLink CDD UniProt Pfam InterPro
HY04AAS1_0208 ACG56900 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
HY04AAS1_0563 ACG57250 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
HY04AAS1_0699 ACG57386 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
HY04AAS1_0819 ACG57506 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
HY04AAS1_0846 ACG57533 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
HY04AAS1_1405 ACG58090 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
EAL only
HY04AAS1_0141 ACG56833 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
HY04AAS1_0209 ACG56901 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
*HY04AAS1_0938 ACG57625 putative diguanylate ... BLink CDD UniProt Pfam InterPro

Persephonella marina EX-H1
GGDEF-EAL
PERMA_0188 ACO04411 signal transduction resp... BLink CDD UniProt Pfam InterPro
PERMA_0255 ACO04767 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
PERMA_0267 ACO03222 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
PERMA_0385 ACO03942 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
PERMA_0575 ACO04171 signal transduction resp... BLink CDD UniProt Pfam InterPro
PERMA_0630 ACO03333 response regulator recei... BLink CDD UniProt Pfam InterPro
PERMA_0989 ACO04017 signal transduction resp... BLink CDD UniProt Pfam InterPro
PERMA_1004 ACO04386 eal/pas/ggdef domain pro... BLink CDD UniProt Pfam InterPro
PERMA_1110 ACO03699 putative eal/ggdef/pas d... BLink CDD UniProt Pfam InterPro
PERMA_1119 ACO03466 ggdef family protein [Pe... BLink CDD UniProt Pfam InterPro
PERMA_1235 ACO03067 response regulator recei... BLink CDD UniProt Pfam InterPro
PERMA_1542 ACO04002 signal transduction resp... BLink CDD UniProt Pfam InterPro
PERMA_1653 ACO04476 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
PERMA_1881 ACO04090 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
PERMA_0610 ACO03144 EAL domain protein [Pers... BLink CDD UniProt Pfam InterPro
PERMA_1649 ACO04666 EAL domain protein [Pers... BLink CDD UniProt Pfam InterPro

Sulfurihydrogenibium azorense Az-Fu1
GGDEF-EAL
SULAZ_0227 ACN99621 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
SULAZ_0401 ACN98852 PAS fold family protein ... BLink CDD UniProt Pfam InterPro
SULAZ_0443 ACN98194 signal transduction resp... BLink CDD UniProt Pfam InterPro
SULAZ_0445 ACN98157 putative signal transduc... BLink CDD UniProt Pfam InterPro
SULAZ_1116 ACN98582 signal transduction resp... BLink CDD UniProt Pfam InterPro
SULAZ_1249 ACN99778 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
SULAZ_1270 ACN98329 eal/ggdef domain protein... BLink CDD UniProt Pfam InterPro
EAL only
SULAZ_1541 ACN99578 cyclic diguanylate phosp... BLink CDD UniProt Pfam InterPro

Sulfurihydrogenibium sp. YO3AOP1
GGDEF-EAL
SYO3AOP1_0011 ACD65662 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
SYO3AOP1_0191 ACD65836 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
SYO3AOP1_1222 ACD66833 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
SYO3AOP1_1560 ACD67158 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
SYO3AOP1_1602 ACD67200 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
SYO3AOP1_1774 ACD67369 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
EAL only
SYO3AOP1_0731 ACD66364 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
*SYO3AOP1_1476 ACD67078 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro

Thermocrinis albus DSM 14484
GGDEF-EAL
Thal_0309 ADC88944 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Thal_0903 ADC89535 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Thal_0972 ADC89604 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Thal_0637 ADC89270 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Thal_0817 ADC89450 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Thermovibrio ammonificans HB-1
GGDEF-EAL
Theam_0396 ADU96369 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Theam_0573 ADU96545 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Theam_0683 ADU96651 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Theam_1004 ADU96971 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Theam_0139 ADU96112 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Theam_1746 ADU97702 EAL domain protein [Ther... BLink CDD UniProt Pfam InterPro

Bacteroidetes
Bacteroides vulgatus ATCC 8482
*BVU_3760 ABR41371 hypothetical protein BVU_... BLink CDD UniProt Pfam InterPro

Salinibacter ruber DSM 13855
SRU_0251 ABC44382 sensory box/ggdef family ... BLink CDD UniProt Pfam InterPro

Chloroflexi
Anaerolinea thermophila UNI-1
GGDEF-EAL
ANT_01710 BAJ62205 hypothetical protein ANT_... BLink CDD UniProt Pfam InterPro
ANT_22330 BAJ64259 hypothetical protein ANT_... BLink CDD UniProt Pfam InterPro
ANT_27490 BAJ64775 putative signaling protei... BLink CDD UniProt Pfam InterPro
EAL only
ANT_01720 BAJ62206 hypothetical protein ANT_... BLink CDD UniProt Pfam InterPro
ANT_02820 BAJ62316 hypothetical protein ANT_... BLink CDD UniProt Pfam InterPro

Chloroflexus aggregans DSM 9485
GGDEF-EAL
Cagg_0553 ACL23492 response regulator receiv... BLink CDD UniProt Pfam InterPro
Cagg_0617 ACL23555 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cagg_3503 ACL26342 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Chloroflexus aurantiacus J-10-fl
GGDEF-EAL
Caur_2977 ABY36176 diguanylate cyclase [Chlo... BLink CDD UniProt Pfam InterPro
Caur_3277 ABY36465 diguanylate cyclase [Chlo... BLink CDD UniProt Pfam InterPro
Caur_3534 ABY36718 diguanylate cyclase [Chlo... BLink CDD UniProt Pfam InterPro

Chloroflexus sp. Y-400-fl
GGDEF-EAL
Chy400_3222 ACM54600 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
Chy400_3537 ACM54908 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
Chy400_3812 ACM55178 response regulator rece... BLink CDD UniProt Pfam InterPro

Herpetosiphon aurantiacus ATCC 23779
GGDEF-EAL
Haur_0630 ABX03278 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Haur_0985 ABX03633 response regulator receiv... BLink CDD UniProt Pfam InterPro
Haur_1108 ABX03756 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Roseiflexus castenholzii DSM 13941
GGDEF-EAL
Rcas_1506 ABU57600 response regulator receiv... BLink CDD UniProt Pfam InterPro
Rcas_3136 ABU59190 response regulator receiv... BLink CDD UniProt Pfam InterPro
Rcas_3309 ABU59360 response regulator receiv... BLink CDD UniProt Pfam InterPro

Roseiflexus sp. RS-1
GGDEF-EAL
RoseRS_2343 ABQ90722 response regulator rece... BLink CDD UniProt Pfam InterPro
RoseRS_3739 ABQ92093 response regulator rece... BLink CDD UniProt Pfam InterPro
RoseRS_3878 ABQ92231 response regulator rece... BLink CDD UniProt Pfam InterPro

Sphaerobacter thermophilus DSM 20745
GGDEF-EAL
Sthe_0710 ACZ38147 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sthe_2695 ACZ40109 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Sthe_0129 ACZ37568 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Thermobaculum terrenum ATCC BAA-798
GGDEF-EAL
Tter_0203 ACZ41125 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Tter_0442 ACZ41363 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Thermomicrobium roseum DSM 5159
GGDEF-EAL
trd_1559 ACM06164 c-di-GMP phosphodiesteras... BLink CDD UniProt Pfam InterPro
trd_1813 ACM04716 putative sensory box prot... BLink CDD UniProt Pfam InterPro
trd_1907 ACM05653 developmental regulator M... BLink CDD UniProt Pfam InterPro
EAL only
trd_1420 ACM05899 unnamed protein product [... BLink CDD UniProt Pfam InterPro
trd_A0737 ACM06717 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Chrysiogenetes
Desulfurispirillum indicum S5
GGDEF-EAL
Selin_0020 ADU64779 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1557 ADU66289 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1742 ADU66471 PAS sensor protein [Desu... BLink CDD UniProt Pfam InterPro
Selin_1873 ADU66600 diguanylate cyclase [Des... BLink CDD UniProt Pfam InterPro
Selin_2418 ADU67133 diguanylate cyclase [Des... BLink CDD UniProt Pfam InterPro
EAL only
Selin_0810 ADU65550 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1213 ADU65948 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1257 ADU65992 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1295 ADU66030 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
Selin_1804 ADU66531 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro

Deferribacteres
Calditerrivibrio nitroreducens DSM 19672
GGDEF-EAL
Calni_0762 ADR18673 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Calni_0801 ADR18712 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Calni_1382 ADR19290 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Calni_1544 ADR19452 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Calni_1626 ADR19533 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Calni_0184 ADR18097 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Calni_1627 ADR19534 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Deferribacter desulfuricans SSM1
GGDEF-EAL
DEFDS_0739 BAI80218 hypothetical protein DEF... BLink CDD UniProt Pfam InterPro
DEFDS_1211 BAI80679 hypothetical protein DEF... BLink CDD UniProt Pfam InterPro
DEFDS_1853 BAI81308 signal transduction sens... BLink CDD UniProt Pfam InterPro
DEFDS_1856 BAI81311 hypothetical protein DEF... BLink CDD UniProt Pfam InterPro
EAL only
DEFDS_0835 BAI80311 signal transduction resp... BLink CDD UniProt Pfam InterPro
DEFDS_P209 BAI81829 hypothetical protein DEF... BLink CDD UniProt Pfam InterPro

Denitrovibrio acetiphilus DSM 12809
GGDEF-EAL
Dacet_0121 ADD66927 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Dacet_1736 ADD68500 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Dacet_2011 ADD68774 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Dacet_2030 ADD68793 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Dacet_2328 ADD69090 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Dacet_2895 ADD69645 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Dacet_1215 ADD67987 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Dacet_1733 ADD68497 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Dacet_1734 ADD68498 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Dacet_2879 ADD69629 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Flexistipes sinusarabici DSM 4947
GGDEF-EAL
Flexsi_0559 AEI14240 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
Flexsi_1699 AEI15345 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro

Deinococcus-Thermus group
Deinococcus deserti VCD115
GGDEF-EAL
Deide_03810 ACO45203 hypothetical proteinD... BLink CDD UniProt Pfam InterPro
Deide_04860 ACO45321 signal transduction r... BLink CDD UniProt Pfam InterPro
Deide_16860 ACO46658 c-di-GMP phosphodiese... BLink CDD UniProt Pfam InterPro
Deide_18060 ACO46793 diguanylate cyclase D... BLink CDD UniProt Pfam InterPro
Deide_19951 ACO46998 diguanylate-cyclase D... BLink CDD UniProt Pfam InterPro
Deide_20430 ACO47059 hypothetical proteinD... BLink CDD UniProt Pfam InterPro
Deide_21850 ACO47211 diguanylate-cyclase D... BLink CDD UniProt Pfam InterPro
Deide_1p00099 ACO47403 diguanylate-cyclase D... BLink CDD UniProt Pfam InterPro
Deide_1p00440 ACO47444 diguanylate-cyclase D... BLink CDD UniProt Pfam InterPro
Deide_1p00800 ACO47485 diguanylate-cyclase D... BLink CDD UniProt Pfam InterPro
Deide_2p02140 ACO47887 diguanylate cyclase i... BLink CDD UniProt Pfam InterPro

Deinococcus gobiensis I-0
GGDEF-EAL
DGo_CA0273 AFD24200 Sensory box/GGDEF family... BLink CDD UniProt Pfam InterPro
DGo_CA0573 AFD24500 Response regulator recei... BLink CDD UniProt Pfam InterPro
DGo_CA0790 AFD24717 Diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
DGo_CA2424 AFD26351 Sensory box/GGDEF family... BLink CDD UniProt Pfam InterPro
DGo_PA0129 AFD27015 Diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
DGo_PA0220 AFD27106 Putative signal transduc... BLink CDD UniProt Pfam InterPro
EAL only
DGo_PA0279 AFD27165 Diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro

Deinococcus maricopensis DSM 21211
GGDEF-EAL
Deima_0106 ADV65770 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0110 ADV65774 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0144 ADV65808 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0168 ADV65832 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0171 ADV65835 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0231 ADV65894 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0394 ADV66054 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_0960 ADV66613 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_1023 ADV66676 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_1551 ADV67200 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_1664 ADV67313 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_1731 ADV67380 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_1866 ADV67513 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_2124 ADV67766 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_2402 ADV68040 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_3009 ADV68638 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Deima_3201 ADV68829 unnamed protein product ... BLink CDD UniProt Pfam InterPro
EAL only
Deima_2222 ADV67860 unnamed protein product ... BLink CDD UniProt Pfam InterPro

Deinococcus peraridilitoris DSM 19664
GGDEF-EAL
Deipe_0185 AFZ65788 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_0728 AFZ66307 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro
Deipe_1772 AFZ67291 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_1930 AFZ67433 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_2126 AFZ67616 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_2987 AFZ68438 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_3712 AFZ69138 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_3856 AFZ69276 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_4132 AFZ69499 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_4219 AFZ69579 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Deipe_4224 AFZ69584 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro

Deinococcus proteolyticus MRP
GGDEF-EAL
Deipr_0212 ADY25385 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
Deipr_0349 ADY25519 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Deipr_0762 ADY25919 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Deipr_0801 ADY25957 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Deipr_2179 ADY27308 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Deipr_2542 ADY27659 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Deipr_2550 ADY27665 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro

Deinococcus radiodurans R1
GGDEF-EAL
DR_0466 AAF10046 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro
DR_0750 AAF10326 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro
DR_1629 AAF11189 c-di-GMP phosphodiesteras... BLink CDD UniProt Pfam InterPro
DR_2299 AAF11843 GGDEF family protein [Dei... BLink CDD UniProt Pfam InterPro
EAL only
DR_2492 NP_296212 hypothetical protein DR2... BLink CDD UniProt Pfam InterPro

Marinithermus hydrothermalis DSM 14884
GGDEF-EAL
Marky_0019 AEB10784 PAS/PAC and GAF sensor-c... BLink CDD UniProt Pfam InterPro
Marky_0607 AEB11357 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
Marky_1287 AEB12027 PAS/PAC and GAF sensor-c... BLink CDD UniProt Pfam InterPro
Marky_1805 AEB12537 GAF sensor-containing di... BLink CDD UniProt Pfam InterPro

Meiothermus ruber DSM 1279
GGDEF-EAL
Mrub_2168 AGK05629 unnamed protein product [... BLink CDD UniProt Pfam InterPro
Mrub_2176 ADD28930 unnamed protein product [... BLink CDD UniProt Pfam InterPro
Mrub_2566 ADD29316 unnamed protein product [... BLink CDD UniProt Pfam InterPro

Meiothermus silvanus DSM 9946
GGDEF-EAL
Mesil_0332 ADH62273 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Mesil_0892 ADH62804 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Mesil_3568 ADH65361 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Mesil_1631 ADH63517 unnamed protein product ... BLink CDD UniProt Pfam InterPro

Oceanithermus profundus DSM 14977
GGDEF-EAL
Ocepr_0112 ADR35575 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Ocepr_0163 ADR35626 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Ocepr_0535 ADR35993 unnamed protein product ... BLink CDD UniProt Pfam InterPro
Ocepr_0614 ADR36072 unnamed protein product ... BLink CDD UniProt Pfam InterPro

Thermus oshimai JL-2
Theos_2426 AFV77403 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro

Thermus scotoductus SA-01
GGDEF-EAL
TSC_c11950 ADW21815 unnamed protein product ... BLink CDD UniProt Pfam InterPro
TSC_c12310 ADW21851 unnamed protein product ... BLink CDD UniProt Pfam InterPro

Thermus sp. CCB_US3_UF1
GGDEF-EAL
TCCBUS3UF1_15680 AEV16609 unnamed protein pro... BLink CDD UniProt Pfam InterPro
EAL only
TCCBUS3UF1_1670 AEV15216 unnamed protein pro... BLink CDD UniProt Pfam InterPro

Thermus thermophilus HB27
GGDEF-EAL
TTC0422 AAS80770 sensory transduction hist... BLink CDD UniProt Pfam InterPro
EAL only
TTC0628 AAS80976 hypothetical protein TTC0... BLink CDD UniProt Pfam InterPro

Truepera radiovictrix DSM 17093
GGDEF-EAL
Trad_0764 ADI13899 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Trad_1476 ADI14597 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Trad_2626 ADI15732 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Trad_1524 ADI14644 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Trad_2898 ADI15996 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Trad_1458 ADI14580 unnamed protein product [... BLink CDD UniProt Pfam InterPro

Fibrobacteres
Fibrobacter succinogenes subsp. succinogenes S85
GGDEF-EAL
Fisuc_0123 ACX73737 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Fisuc_0333 ACX73945 response regulator recei... BLink CDD UniProt Pfam InterPro
Fisuc_1205 ACX74808 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Fisuc_2812 ACX76395 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Fisuc_1145 ADL26246 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Fusobacteria
Ilyobacter polytropus DSM 2926
GGDEF-EAL
Ilyop_0354 ADO82142 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Ilyop_0951 ADO82733 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Ilyop_0953 ADO82735 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Ilyop_1280 ADO83061 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Ilyop_2210 ADO83973 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Ilyop_2227 ADO83989 response regulator recei... BLink CDD UniProt Pfam InterPro
Ilyop_2401 ADO84160 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Ilyop_2628 ADO84385 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Ilyop_2814 ADO84568 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Ilyop_0789 ADO82575 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Gemmatimonadetes
Gemmatimonas aurantiaca T-27
GGDEF-EAL
GAU_0382 BAH37424 putative signaling protei... BLink CDD UniProt Pfam InterPro
GAU_1128 BAH38170 putative signaling protei... BLink CDD UniProt Pfam InterPro
GAU_2018 BAH39060 putative response regulat... BLink CDD UniProt Pfam InterPro
GAU_2865 BAH39907 response regulator [Gemma... BLink CDD UniProt Pfam InterPro
GAU_3077 BAH40119 hypothetical protein GAU_... BLink CDD UniProt Pfam InterPro
EAL only
GAU_0252 BAH37294 hypothetical protein GAU_... BLink CDD UniProt Pfam InterPro
GAU_0294 BAH37336 hypothetical protein GAU_... BLink CDD UniProt Pfam InterPro

Nitrospirae
Candidatus Nitrospira defluvii
GGDEF-EAL
NIDE2522 CBK42232 sensory response regulato... BLink CDD UniProt Pfam InterPro

Leptospirillum ferriphilum ML-04
GGDEF-EAL
LFML04_0107 AFS52359 diguanylate cyclase [Lep... BLink CDD UniProt Pfam InterPro
LFML04_0467 AFS52705 signal transduction prot... BLink CDD UniProt Pfam InterPro
LFML04_0615 AFS52850 signal transduction prot... BLink CDD UniProt Pfam InterPro
LFML04_0729 AFS52963 signal transduction prot... BLink CDD UniProt Pfam InterPro
LFML04_0903 AFS53135 Diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
LFML04_0952 AFS53184 signal transduction prot... BLink CDD UniProt Pfam InterPro
LFML04_0977 AFS53208 GAF sensor-containing di... BLink CDD UniProt Pfam InterPro
LFML04_1128 AFS53358 hypothetical protein LFM... BLink CDD UniProt Pfam InterPro
LFML04_1525 AFS53735 response regulator recei... BLink CDD UniProt Pfam InterPro
LFML04_1898 AFS54098 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
EAL only
LFML04_0050 AFS52304 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
LFML04_0369 AFS52611 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
LFML04_0814 AFS53048 Diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro

Leptospirillum ferrooxidans C2-3
GGDEF-EAL
LFE_0421 BAM06142 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_0437 BAM06158 diguanylate cyclase [Leptos... BLink CDD UniProt Pfam InterPro
LFE_0488 BAM06206 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_0596 BAM06312 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_0600 BAM06316 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_1010 BAM06713 signal transduction histidi... BLink CDD UniProt Pfam InterPro
LFE_1170 BAM06861 diguanylate cyclase [Leptos... BLink CDD UniProt Pfam InterPro
LFE_1834 BAM07512 diguanylate cyclase [Leptos... BLink CDD UniProt Pfam InterPro
LFE_1877 BAM07555 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_1994 BAM07669 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_2064 BAM07738 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_2080 BAM07753 diguanylate cyclase [Leptos... BLink CDD UniProt Pfam InterPro
LFE_2300 BAM07972 diguanylate cyclase/phospho... BLink CDD UniProt Pfam InterPro
LFE_2317 BAM07989 diguanylate cyclase [Leptos... BLink CDD UniProt Pfam InterPro
LFE_2360 BAM08032 hypothetical protein LFE_23... BLink CDD UniProt Pfam InterPro
LFE_2361 BAM08033 diguanylate cyclase/phospho... BLink CDD UniProt Pfam InterPro
EAL only
LFE_0026 BAM05757 diguanylate phosphodiestera... BLink CDD UniProt Pfam InterPro
LFE_0574 BAM06290 diguanylate phosphodiestera... BLink CDD UniProt Pfam InterPro
LFE_1157 BAM06848 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro
LFE_1810 BAM07488 diguanylate phosphodiestera... BLink CDD UniProt Pfam InterPro
LFE_1811 BAM07489 diguanylate phosphodiestera... BLink CDD UniProt Pfam InterPro
LFE_2464 BAM08135 PAS/PAC sensor-containing d... BLink CDD UniProt Pfam InterPro

Thermodesulfovibrio yellowstonii DSM 11347
EAL only
THEYE_A0172 ACI22070 LssE protein [Thermodes... BLink CDD UniProt Pfam InterPro
THEYE_A1785 ACI20769 EAL domain, putative [T... BLink CDD UniProt Pfam InterPro

Planctomycetes
Phycisphaera mikurensis NBRC 102666
GGDEF-EAL
PSMK_01720 BAM02331 hypothetical protein PSMK... BLink CDD UniProt Pfam InterPro
PSMK_15230 BAM03682 hypothetical protein PSMK... BLink CDD UniProt Pfam InterPro
PSMK_16530 BAM03812 putative response regulat... BLink CDD UniProt Pfam InterPro
PSMK_18890 BAM04048 putative response regulat... BLink CDD UniProt Pfam InterPro
PSMK_23380 BAM04497 hypothetical protein PSMK... BLink CDD UniProt Pfam InterPro
PSMK_25930 BAM04752 hypothetical protein PSMK... BLink CDD UniProt Pfam InterPro
PSMK_26030 BAM04762 hypothetical protein PSMK... BLink CDD UniProt Pfam InterPro

Pirellula staleyi DSM 6068
EAL only
Psta_0487 ADB15175 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Psta_4271 ADB18919 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Psta_4530 ADB19172 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Planctomyces brasiliensis DSM 5305
EAL only
Plabr_4368 ADY61941 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Rhodopirellula baltica SH 1
GGDEF-EAL
RB3251 CAD73079 hypothetical protein RB32... BLink CDD UniProt Pfam InterPro
RB3605 CAD73290 conserved hypothetical pr... BLink CDD UniProt Pfam InterPro
EAL only
RB12766 CAD77769 conserved hypothetical pr... BLink CDD UniProt Pfam InterPro

Spirochaetes
Borrelia afzelii PKo
BAPKO_0370 ABH01627 hypothetical protein BAPK... BLink CDD UniProt Pfam InterPro

Borrelia bissettii DN127
BbiDN127_0358 AEL18542 unnamed protein produ... BLink CDD UniProt Pfam InterPro

Borrelia burgdorferi B31
BB0363 AAC66750 periplasmic protein [Borr... BLink CDD UniProt Pfam InterPro

Borrelia crocidurae str. Achema
Q7M_371 AFI31150 Periplasmic protein [Borr... BLink CDD UniProt Pfam InterPro

Borrelia duttonii Ly
BDU_360 ACH93312 periplasmic protein [Borr... BLink CDD UniProt Pfam InterPro

Borrelia garinii PBi
BG0362 AAU07215 periplasmic protein [Borr... BLink CDD UniProt Pfam InterPro

Borrelia hermsii DAH
BH0363 AAX16875 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro

Borrelia recurrentis A1
BRE_364 ACH94609 periplasmic protein [Borr... BLink CDD UniProt Pfam InterPro

Borrelia turicatae 91E135
BT0363 AAX17696 response regulatory prote... BLink CDD UniProt Pfam InterPro

Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)'
GGDEF-EAL
LBF_0290 ABZ92836 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_0298 ABZ92844 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_1686 ABZ94193 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_1827 ABZ94334 Response regulator of a t... BLink CDD UniProt Pfam InterPro
LBF_3312 ABZ95779 Signal transduction prote... BLink CDD UniProt Pfam InterPro
EAL only
LBF_0054 ABZ92601 hypothetical protein LBF_... BLink CDD UniProt Pfam InterPro
LBF_0099 ABZ92645 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_0272 ABZ92817 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_1215 ABZ93739 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBF_1866 ABZ94372 Signal transduction prote... BLink CDD UniProt Pfam InterPro

Leptospira borgpetersenii serovar Hardjo-bovis L550
EAL only
LBL_0751 ABJ78310 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBL_2032 ABJ79452 Response regulator [Lepto... BLink CDD UniProt Pfam InterPro
LBL_2723 ABJ80065 Signal transduction prote... BLink CDD UniProt Pfam InterPro
LBL_4130 ABJ80449 hypothetical protein LBL_... BLink CDD UniProt Pfam InterPro

Leptospira interrogans serovar Lai str. 56601
GGDEF-EAL
LA1185 AAN48384 Response regulator [Lepto... BLink CDD UniProt Pfam InterPro
LA3909 AAN51107 hypothetical protein LA39... BLink CDD UniProt Pfam InterPro
LB235 AAN51794 response regulator [Lepto... BLink CDD UniProt Pfam InterPro
EAL only
LA1983 AAN49183 hypothetical protein LA19... BLink CDD UniProt Pfam InterPro
LA2827 AAN50026 response regulator [Lepto... BLink CDD UniProt Pfam InterPro
LA3104 AAN50302 hypothetical protein LA31... BLink CDD UniProt Pfam InterPro
LB133 AAN51692 probable protein containi... BLink CDD UniProt Pfam InterPro
LB261 AAN51820 hypothetical protein LB26... BLink CDD UniProt Pfam InterPro

Spirochaeta africana DSM 8902
GGDEF-EAL
Spiaf_0728 AFG36827 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
Spiaf_0922 AFG37011 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
Spiaf_0990 AFG37078 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
Spiaf_1104 AFG37191 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
Spiaf_1329 AFG37403 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
Spiaf_1811 AFG37868 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro
Spiaf_1813 AFG37870 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro
Spiaf_2169 AFG38206 diguanylate cyclase [Spir... BLink CDD UniProt Pfam InterPro
EAL only
Spiaf_1202 AFG37281 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
Spiaf_1770 AFG37827 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
Spiaf_2525 AFG38555 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro

Sphaerochaeta globus str. Buddy
GGDEF-EAL
SpiBuddy_1043 ADY12868 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_1058 ADY12883 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_1466 ADY13291 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_1691 ADY13516 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_2660 ADY14471 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_2740 ADY14549 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_2744 ADY14553 unnamed protein produ... BLink CDD UniProt Pfam InterPro
SpiBuddy_2805 ADY14613 unnamed protein produ... BLink CDD UniProt Pfam InterPro
EAL only
SpiBuddy_0688 ADY12515 unnamed protein produ... BLink CDD UniProt Pfam InterPro

Sphaerochaeta pleomorpha str. Grapes
GGDEF-EAL
SpiGrapes_0326 AEV28185 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_0811 AEV28639 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_0926 AEV28752 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_1060 AEV28884 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_1846 AEV29640 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_2398 AEV30169 unnamed protein prod... BLink CDD UniProt Pfam InterPro
EAL only
SpiGrapes_0890 AEV28716 unnamed protein prod... BLink CDD UniProt Pfam InterPro
SpiGrapes_2236 AEV30012 unnamed protein prod... BLink CDD UniProt Pfam InterPro

Spirochaeta caldaria DSM 7334
GGDEF-EAL
Spica_1891 AEJ20024 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
Spica_2064 AEJ20191 response regulator recei... BLink CDD UniProt Pfam InterPro
EAL only
Spica_2127 AEJ20250 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Spirochaeta smaragdinae DSM 11293
GGDEF-EAL
Spirs_1449 ADK80576 response regulator recei... BLink CDD UniProt Pfam InterPro
Spirs_2532 ADK81645 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Spirs_3249 ADK82347 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Spirs_4146 ADK83226 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro

Spirochaeta thermophila DSM 6192
GGDEF-EAL
STHERM_c02950 ADN01268 sensory box/GGDEF fam... BLink CDD UniProt Pfam InterPro
STHERM_c04650 ADN01437 hypothetical protein ... BLink CDD UniProt Pfam InterPro
STHERM_c04670 ADN01439 hypothetical protein ... BLink CDD UniProt Pfam InterPro
STHERM_c14140 ADN02354 hypothetical protein ... BLink CDD UniProt Pfam InterPro
STHERM_c16340 ADN02574 hypothetical protein ... BLink CDD UniProt Pfam InterPro
STHERM_c19190 ADN02854 hypothetical protein ... BLink CDD UniProt Pfam InterPro
STHERM_c21360 ADN03066 hypothetical protein ... BLink CDD UniProt Pfam InterPro

Treponema brennaborense DSM 12168
GGDEF-EAL
Trebr_0400 AEE15847 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Trebr_0594 AEE16037 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Trebr_1107 AEE16539 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro
Trebr_1709 AEE17131 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Trebr_2203 AEE17615 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Trebr_0860 AEE16296 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Treponema denticola ATCC 35405
TDE0128 AAS10626 HAMP domain/GGDEF domain/... BLink CDD UniProt Pfam InterPro
TDE2075 AAS12587 GGDEF domain/EAL domain p... BLink CDD UniProt Pfam InterPro

Treponema succinifaciens DSM 2489
GGDEF-EAL
Tresu_1403 AEB14309 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Tresu_2043 AEB14916 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
Tresu_2485 AEB15347 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
EAL only
Tresu_2026 AEB14899 diguanylate phosphodiest... BLink CDD UniProt Pfam InterPro

Turneriella parva DSM 21527
GGDEF-EAL
Turpa_0412 AFM11068 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_0446 AFM11102 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_0750 AFM11401 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_0829 AFM11480 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_1450 AFM12098 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_1727 AFM12374 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_1803 AFM12450 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Turpa_2445 AFM13087 response regulator receiv... BLink CDD UniProt Pfam InterPro
Turpa_3006 AFM13645 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Turpa_0513 AFM11167 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Turpa_1700 AFM12348 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Turpa_3181 AFM13820 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Turpa_3704 AFM14338 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Tenericutes
Acholeplasma laidlawii PG-8A
GGDEF-EAL
ACL_1014 ABX81624 surface-anchored signal t... BLink CDD UniProt Pfam InterPro
ACL_1015 ABX81625 surface-anchored signal t... BLink CDD UniProt Pfam InterPro
ACL_1127 ABX81736 predicted signal transduc... BLink CDD UniProt Pfam InterPro
ACL_1183 ABX81782 predicted signal transduc... BLink CDD UniProt Pfam InterPro
EAL only
ACL_0866 ABX81479 hypothetical protein with... BLink CDD UniProt Pfam InterPro

Thermodesulfobacteria
Thermodesulfatator indicus DSM 15286
GGDEF-EAL
Thein_0974 AEH44846 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro

Thermodesulfobacterium sp. OPB45
GGDEF-EAL
TOPB45_0240 AEH22354 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
TOPB45_0460 AEH22563 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro
TOPB45_1083 AEH23174 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
TOPB45_1195 AEH23282 PAS/PAC sensor-containi... BLink CDD UniProt Pfam InterPro

Thermotogae
Fervidobacterium nodosum Rt17-B1
Fnod_0472 ABS60337 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Fervidobacterium pennivorans DSM 9078
GGDEF-EAL
Ferpe_0525 AFG34663 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro

Mesotoga prima MesG1.Ag.4.2
GGDEF-EAL
Theba_2266 AFK07895 PAS domain-containing pro... BLink CDD UniProt Pfam InterPro

Petrotoga mobilis SJ95
Pmob_0538 ABX31272 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Thermosipho africanus TCF52B
THA_1109 ACJ75562 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro

Thermosipho melanesiensis BI429
Tmel_0750 ABR30613 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Thermotoga lettingae TMO
Tlet_1224 ABV33785 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

ARCHAEA
Acidianus hospitalis W1
*Ahos_1343 AEE94226 hypothetical protein Aho... BLink CDD UniProt Pfam InterPro

Picrophilus torridus DSM 9790
*PTO0908 AAT43493 hypothetical protein PTO0... BLink CDD UniProt Pfam InterPro
Please send corrections, questions and comments to Michael Galperin