EAL domains in actinobacteria

c-di-GMP phosphodiesterase class I (EAL) domains in Actinobacteria

Actinobacteria
. Acidimicrobium ferrooxidans DSM 10331 .................. 10 hits
. Acidothermus cellulolyticus 11B ........................ 10 hits
. Actinoplanes missouriensis 431 ......................... 30 hits
. Actinoplanes sp. SE50/110 .............................. 58 hits
. Actinosynnema mirum DSM 43827 .......................... 10 hits
. Amycolatopsis mediterranei U32 ......................... 7 hits
. Amycolicicoccus subflavus DQS3-9A1 ..................... 0 hits
. Arcanobacterium haemolyticum DSM 20595 ................. 0 hits
. Arthrobacter arilaitensis Re117 ........................ 0 hits
. Arthrobacter aurescens TC1 ............................. 5 hits
. Arthrobacter chlorophenolicus A6 ....................... 5 hits
. Arthrobacter phenanthrenivorans Sphe3 .................. 3 hits
. Arthrobacter sp. FB24 .................................. 8 hits
. Arthrobacter sp. Rue61a ................................ 4 hits
. Atopobium parvulum DSM 20469 ........................... 0 hits
. Beutenbergia cavernae DSM 12333 ........................ 0 hits
. Bifidobacterium adolescentis ATCC 15703 ................ 0 hits
. Bifidobacterium animalis subsp. lactis AD011 ........... 0 hits
. Bifidobacterium asteroides PRL2011...................... 0 hits
. Bifidobacterium bifidum S17 ............................ 0 hits
. Bifidobacterium breve ACS-071-V-Sch8b .................. 2 hits
. Bifidobacterium dentium Bd1 ............................ 0 hits
. Bifidobacterium longum DJO10A........................... 0 hits
. Bifidobacterium longum subsp. longum JDM301 ............ 1 hit
. Blastococcus saxobsidens DD2 ........................... 21 hits
. Brachybacterium faecium DSM 4810 ....................... 0 hits
. Catenulispora acidiphila DSM 44928 ..................... 7 hits
. Cellulomonas [Cellvibrio] gilvus ATCC 13127 ............ 9 hits
. Cellulomonas fimi ATCC 484 ............................. 8 hits
. Cellulomonas flavigena DSM 20109 ....................... 8 hits
. Clavibacter michiganensis subsp. michigan. NCPPB 382.... 0 hits
. Conexibacter woesei DSM 14684 .......................... 10 hits
. Coriobacterium glomerans PW2 ........................... 0 hits
. Corynebacterium aurimucosum ATCC 700975 ................ 0 hits
. Corynebacterium diphtheriae NCTC 13129 ................. 0 hits
. Corynebacterium efficiens YS-314 ....................... 0 hits
. Corynebacterium glutamicum ATCC 13032 .................. 1 hit
. Corynebacterium jeikeium K411 .......................... 0 hits
. Corynebacterium kroppenstedtii DSM 44385 ............... 0 hits
. Corynebacterium pseudotuberculosis FRC41 ............... 0 hits
. Corynebacterium resistens DSM 45100 .................... 0 hits
. Corynebacterium ulcerans BR-AD22 ....................... 0 hits
. Corynebacterium urealyticum DSM 7109 ................... 0 hits
. Corynebacterium variabile DSM 44702 .................... 0 hits
. Cryptobacterium curtum DSM 15641 ....................... 0 hits
. Eggerthella lenta DSM 2243 ............................. 10 hits
. Eggerthella sp. YY7918 ................................. 12 hits
. Frankia alni ACN14a .................................... 13 hits
. Frankia sp. CcI3 ....................................... 10 hits
. Frankia sp. EAN1pec .................................... 19 hits
. Frankia sp. EuI1c ...................................... 23 hits
. Frankia symbiont of Datisca glomerata .................. 10 hits
. Gardnerella vaginalis 409-05 ........................... 0 hits
. Geodermatophilus obscurus DSM 43160 .................... 17 hits
. Gordonia bronchialis DSM 43247 ......................... 2 hits
. Gordonia polyisoprenivorans VH2 ........................ 3 hits
. Gordonia sp. KTR9 ...................................... 2 hits
. Intrasporangium calvum DSM 43043 ....................... 0 hits
. Isoptericola variabilis 225 ............................ 0 hits
. Jonesia denitrificans DSM 20603 ........................ 0 hits
. Kineococcus radiotolerans SRS30216 ..................... 44 hits
. Kitasatospora setae KM-6054 ............................ 4 hits
. Kocuria rhizophila DC2201 .............................. 0 hits
. Kribbella flavida DSM 17836 ............................ 0 hits
. Kytococcus sedentarius DSM 20547 ....................... 0 hits
. Leifsonia xyli subsp. xyli str. CTCB07 ................. 0 hits
. Microbacterium testaceum StLB037 ....................... 0 hits
. Micrococcus luteus NCTC 2665 ........................... 0 hits
. Microlunatus phosphovorus NM-1 ......................... 0 hits
. Micromonospora aurantiaca ATCC 27029 ................... 9 hits
. Micromonospora sp. L5 .................................. 9 hits
. Mobiluncus curtisii ATCC 43063 ......................... 0 hits
. Modestobacter marinus str. BC501 ....................... 27 hits
. Mycobacterium abscessus ATCC 19977 ..................... ? hits
. Mycobacterium africanum GM041182 ....................... 2 hita
. Mycobacterium avium subsp. paratuberculosis K-10 ....... 3 hits
. Mycobacterium bovis AF2122/97 .......................... 2 hits
. Mycobacterium canettii CIPT 140010059 .................. 2 hits
. Mycobacterium chubuense NBB4 ........................... 3 hits
. Mycobacterium gilvum PYR-GCK ........................... 10 hits
. Mycobacterium indicus pranii MTCC 9506 ................. 3 hits
. Mycobacterium intracellulare ATCC 13950 ................ 3 hits
. Mycobacterium leprae TN ................................ 2 hits
. Mycobacterium marinum M ................................ 0 hits
. Mycobacterium rhodesiae NBB3 ........................... 2 hits
. Mycobacterium smegmatis str. MC2 155 ................... 1 hit
. Mycobacterium sp. JDM601 ............................... 1 hit
. Mycobacterium sp. JLS .................................. 4 hits
. Mycobacterium sp. KMS .................................. 4 hits
. Mycobacterium sp. MCS .................................. 4 hits
. Mycobacterium sp. MOTT36Y .............................. 3 hits
. Mycobacterium sp. Spyr1 ................................ 10 hits
. Mycobacterium tuberculosis H37Rv ....................... 2 hits
. Mycobacterium ulcerans Agy99 ........................... 0 hits
. Mycobacterium vanbaalenii PYR-1 ........................ 5 hits
. Nakamurella multipartita DSM 44233 ..................... 6 hits
. Nocardia brasiliensis ATCC 700358 ...................... 4 hits
. Nocardia cyriacigeorgica GUH-2 ......................... 2 hits
. Nocardia farcinica IFM 10152 ........................... 2 hits
. Nocardioides sp. JS614 ................................. 2 hits
. Nocardiopsis alba ATCC BAA-2165 ........................ 3 hits
. Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111. 3 hits
. Olsenella uli DSM 7084 ................................. 1 hit
. Propionibacterium acidipropionici ATCC 4875 ............ 0 hits
. Propionibacterium acnes KPA171202 ...................... 0 hits
. Propionibacterium freudenreichii shermanii CIP 103027 .. 0 hits
. Propionibacterium propionicum F0230a ................... 0 hits
. Pseudonocardia dioxanivorans CB1190 .................... 4 hits
. Renibacterium salmoninarum ATCC 33209 .................. 0 hits
. Rhodococcus equi 103S .................................. 2 hits
. Rhodococcus erythropolis PR4 ........................... 5 hits
. Rhodococcus jostii RHA1 ................................ 3 hits
. Rhodococcus opacus B4 .................................. 2 hits
. Rothia dentocariosa ATCC 17931 ......................... 0 hits
. Rothia mucilaginosa DY-18 .............................. 0 hits
. Rubrobacter xylanophilus DSM 9941 ...................... 6 hits
. Saccharomonospora viridis DSM 43017 .................... 3 hits
. Saccharopolyspora erythraea NRRL 2338 .................. 12 hits
. Saccharothrix espanaensis DSM 44229 .................... 10 hits
. Salinispora arenicola CNS-205 .......................... 8 hits
. Salinispora tropica CNB-440 ............................ 6 hits
. Sanguibacter keddieii DSM 10542 ........................ 0 hits
. Segniliparus rotundus DSM 44985 ........................ 0 hits
. Slackia heliotrinireducens DSM 20476 ................... 1 hit
. Stackebrandtia nassauensis DSM 44728 ................... 3 hits
. Streptomyces avermitilis MA-4680 ....................... 5 hits
. Streptomyces cattleya NRRL 8057 ........................ 3 hits
. Streptomyces bingchenggensis BCW-1 ..................... 4 hits
. Streptomyces coelicolor A3(2) .......................... 5 hits
. Streptomyces flavogriseus ATCC 33331 ................... 4 hits
. Streptomyces griseus subsp. griseus NBRC 13350 ......... 4 hits
. Streptomyces hygroscopicus subsp. jinggangensis 5008 ... 4 hits
. Streptomyces scabiei 87.22 ............................. 4 hits
. Streptomyces sp. SirexAA-E ............................. 4 hits
. Streptomyces venezuelae ATCC 10712 ..................... 5 hits
. Streptomyces violaceusniger Tu 4113 .................... 5 hits
. Streptosporangium roseum DSM 43021 ..................... 3 hits
. Thermobifida fusca YX .................................. 3 hits
. Thermobispora bispora DSM 43833 ........................ 2 hits
. Thermomonospora curvata DSM 43183 ...................... 2 hits
. Tropheryma whipplei TW08/27 ............................ 0 hits
. Tsukamurella paurometabola DSM 20162 ................... 1 hit
. Verrucosispora maris AB-18-032 ......................... 9 hits
. Xylanimonas cellulosilytica DSM 15894 .................. 0 hits
Actinobacteria
Acidimicrobium ferrooxidans DSM 10331
GGDEF-EAL
Afer_0820 ACU53766 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Afer_1101 ACU54034 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Afer_1156 ACU54089 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Afer_1385 ACU54311 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Afer_1469 ACU54392 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Afer_1525 ACU54448 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Afer_0022 ACU52997 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Afer_1401 ACU54325 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Afer_1402 ACU54326 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Afer_1731 ACU54647 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Acidothermus cellulolyticus 11B
GGDEF-EAL
Acel_0823 ABK52596 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1420 ABK53192 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1434 ABK53206 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1481 ABK53253 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1662 ABK53434 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1740 ABK53512 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Acel_1905 ABK53677 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Acel_0529 ABK52302 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Acel_0828 ABK52601 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Acel_2099 ABK53871 response regulator receiv... BLink CDD UniProt Pfam InterPro

Actinoplanes missouriensis 431
GGDEF-EAL
AMIS_4460 BAL85666 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_4710 BAL85691 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_5830 BAL85803 putative cGMP-specific ph... BLink CDD UniProt Pfam InterPro
AMIS_8060 BAL86026 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_9110 BAL86131 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_9260 BAL86146 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_30470 BAL88267 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_30480 BAL88268 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_31150 BAL88335 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_34150 BAL88635 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_36530 BAL88873 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_39400 BAL89160 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_40300 BAL89250 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_42070 BAL89427 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_47760 BAL89996 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_48190 BAL90039 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_54350 BAL90655 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_56640 BAL90884 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_60690 BAL91289 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_61380 BAL91358 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_63830 BAL91603 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_66290 BAL91849 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_68050 BAL92025 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_71230 BAL92343 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_71300 BAL92350 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
AMIS_71380 BAL92358 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
AMIS_80810 BAL93301 diguanylate cyclase [Acti... BLink CDD UniProt Pfam InterPro
EAL only
AMIS_22740 BAL87494 hypothetical protein AMIS... BLink CDD UniProt Pfam InterPro
AMIS_53240 BAL90544 hypothetical protein AMIS... BLink CDD UniProt Pfam InterPro
AMIS_79280 BAL93148 hypothetical protein AMIS... BLink CDD UniProt Pfam InterPro

Actinoplanes sp. SE50/110
GGDEF-EAL
ACPL_587 AEV81484 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_615 AEV81512 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_762 AEV81659 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_972 AEV81869 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_985 AEV81882 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_1134 AEV82031 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_1150 AEV82047 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_2546 AEV83441 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_2684 AEV83579 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_2771 AEV83666 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_2823 AEV83718 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_2869 AEV83764 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_2885 AEV83780 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3304 AEV84199 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3377 AEV84272 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_3398 AEV84293 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3415 AEV84310 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3461 AEV84356 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3519 AEV84414 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_3557 AEV84452 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3562 AEV84457 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3563 AEV84458 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3779 AEV84674 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3922 AEV84817 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_4027 AEV84922 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_4059 AEV84954 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_4376 AEV85267 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_4686 AEV85577 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_4725 AEV85616 signal transduction prote... BLink CDD UniProt Pfam InterPro
ACPL_4821 AEV85712 Protein gmr [Actinoplanes... BLink CDD UniProt Pfam InterPro
ACPL_4879 AEV85770 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5094 AEV85981 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5096 AEV85983 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5310 AEV86197 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5361 AEV86248 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5521 AEV86408 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_5532 AEV86419 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_5680 AEV86567 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_6203 AEV87088 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_6616 AEV87498 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_6886 AEV87768 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_7037 AEV87917 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_7372 AEV88252 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_7381 AEV88261 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_7389 AEV88269 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_8334 AEV89210 putative signaling protei... BLink CDD UniProt Pfam InterPro
EAL only
ACPL_315 AEV81212 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_677 AEV81574 putative cellulose syntha... BLink CDD UniProt Pfam InterPro
ACPL_2719 AEV83614 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_3239 AEV84134 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_3288 AEV84183 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_3661 AEV84556 Phytochrome-like protein ... BLink CDD UniProt Pfam InterPro
ACPL_4813 AEV85704 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_5203 AEV86090 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro
ACPL_5601 AEV86488 Signaling protein ykoW [A... BLink CDD UniProt Pfam InterPro
ACPL_6398 AEV87280 putative signaling protei... BLink CDD UniProt Pfam InterPro
ACPL_8215 AEV89093 Cellulose synthase A cata... BLink CDD UniProt Pfam InterPro
*ACPL_6396 AEV87278 hypothetical protein ACPL... BLink CDD UniProt Pfam InterPro

Actinosynnema mirum DSM 43827
GGDEF-EAL
Amir_1306 ACU35258 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_2287 ACU36227 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_2555 ACU36492 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_3414 ACU37312 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_5145 ACU38966 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_5415 ACU39234 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_6223 ACU40028 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_6278 ACU40082 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_6649 ACU40446 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Amir_6871 ACU40667 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Amycolatopsis mediterranei U32
GGDEF-EAL
AMED_0382 ADJ42204 signal transduction prote... BLink CDD UniProt Pfam InterPro
AMED_0585 ADJ42405 signal sensor protein [Am... BLink CDD UniProt Pfam InterPro
AMED_2854 ADJ44648 hypothetical protein AMED... BLink CDD UniProt Pfam InterPro
AMED_2874 ADJ44668 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
AMED_4352 ADJ46125 signal transduction prote... BLink CDD UniProt Pfam InterPro
AMED_7514 ADJ49227 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
AMED_8278 ADJ49976 signal transduction prote... BLink CDD UniProt Pfam InterPro

Arthrobacter aurescens TC1
GGDEF-EAL
AAur_0628 ABM08422 putative GGDEF domain/EAL... BLink CDD UniProt Pfam InterPro
AAur_3242 ABM10160 putative GGDEF domain/EAL... BLink CDD UniProt Pfam InterPro
AAur_pTC20236 ABM10776 Sensory Box Protein [A... BLink CDD UniProt Pfam InterPro
EAL only
AAur_0324 ABM09647 putative EAL domain prote... BLink CDD UniProt Pfam InterPro
AAur_1869 ABM09442 putative EAL domain prote... BLink CDD UniProt Pfam InterPro

Arthrobacter chlorophenolicus A6
GGDEF-EAL
Achl_0233 ACL38234 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Achl_1149 ACL39140 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Achl_2853 ACL40818 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Achl_0232 ACL38233 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Achl_1691 ACL39678 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Arthrobacter phenanthrenivorans Sphe3
GGDEF-EAL
Asphe3_11180 ADX72300 PAS domain S-box/digua... BLink CDD UniProt Pfam InterPro
Asphe3_02460 ADX71464 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
EAL only
Asphe3_02450 ADX71463 diguanylate cyclase do... BLink CDD UniProt Pfam InterPro

Arthrobacter sp. FB24
GGDEF-EAL
Arth_0113 ABK01514 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Arth_1068 ABK02462 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Arth_1783 ABK03173 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Arth_3769 ABK05144 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Arth_1771 ABK03162 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Arth_1906 ABK03288 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Arth_1985 ABK03366 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Arth_3854 ABK05229 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Arthrobacter sp. Rue61a
GGDEF-EAL
ARUE_c05950 AFR27530 hypothetical protein ARUE... BLink CDD UniProt Pfam InterPro
ARUE_c33780 AFR30259 signaling protein [Arthro... BLink CDD UniProt Pfam InterPro
EAL only
ARUE_c03220 AFR27262 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
ARUE_c20030 AFR28908 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro

Bifidobacterium breve ACS-071-V-Sch8b
GGDEF-EAL
HMPREF9228_0033 AEF27934 diguanylate cyclase ... BLink CDD UniProt Pfam InterPro
HMPREF9228_1243 AEF27186 diguanylate cyclase ... BLink CDD UniProt Pfam InterPro

Bifidobacterium longum subsp. longum JDM301
GGDEF-EAL
BLJ_1525 ADH00968 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Blastococcus saxobsidens DD2
GGDEF-EAL
BLASA_0086 CCG01085 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
BLASA_0334 CCG01311 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
BLASA_0690 CCG01645 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
BLASA_0914 CCG01864 putative Diguanylate cycl... BLink CDD UniProt Pfam InterPro
BLASA_0924 CCG01874 putative Diguanylate kina... BLink CDD UniProt Pfam InterPro
BLASA_0941 CCG01891 putative Diguanylate kina... BLink CDD UniProt Pfam InterPro
BLASA_1018 CCG01964 putative Diguanylate cycl... BLink CDD UniProt Pfam InterPro
BLASA_1302 CCG02240 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro
BLASA_2436 CCG03337 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
BLASA_3852 CCG04683 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
BLASA_3969 CCG04797 diguanylate kinase [Blast... BLink CDD UniProt Pfam InterPro
BLASA_4334 CCG05156 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
BLASA_4971 CCG05745 diguanylate kinase [Blast... BLink CDD UniProt Pfam InterPro
EAL only
BLASA_0132 CCG01131 putative Diguanylate cycl... BLink CDD UniProt Pfam InterPro
BLASA_0273 CCG01251 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
BLASA_1182 CCG02123 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
BLASA_1469 CCG02401 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
BLASA_1783 CCG02702 Two component diguanylate... BLink CDD UniProt Pfam InterPro
BLASA_3906 CCG04737 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
BLASA_4932 CCG05707 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
*BLASA_2082 CCG02993 hypothetical protein BLAS... BLink CDD UniProt Pfam InterPro
*BLASA_3005 CCG03876 hypothetical protein BLAS... BLink CDD UniProt Pfam InterPro

Catenulispora acidiphila DSM 44928
GGDEF-EAL
Caci_0595 ACU69532 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_1314 ACU70238 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_2481 ACU71399 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_3344 ACU72251 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_4634 ACU73495 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_5159 ACU74018 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Caci_6207 ACU75061 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Cellulomonas fimi ATCC 484
GGDEF-EAL
Celf_0829 AEE44969 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celf_1558 AEE45692 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Celf_1985 AEE46115 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celf_2724 AEE46848 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celf_3281 AEE47395 diguanylate cyclase [Cell... BLink CDD UniProt Pfam InterPro
Celf_3653 AEE47760 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
EAL only
Celf_2367 AEE46494 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Celf_2368 AEE46495 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Cellulomonas flavigena DSM 20109
GGDEF-EAL
Cfla_0236 ADG73155 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cfla_1131 ADG74035 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cfla_1425 ADG74323 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cfla_1535 ADG74433 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cfla_1840 ADG74737 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cfla_2825 ADG75710 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Cfla_2226 ADG75117 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Cfla_2227 ADG75118 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Cellulomonas [Cellvibrio] gilvus ATCC 13127
GGDEF-EAL
Celgi_1789 AEI12296 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celgi_2056 AEI12557 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celgi_2392 AEI12891 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celgi_2651 AEI13150 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celgi_2853 AEI13346 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Celgi_3011 AEI13503 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Celgi_0444 AEI10966 Diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Celgi_1216 AEI11735 Diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Celgi_1217 AEI11736 Diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Conexibacter woesei DSM 14684
GGDEF-EAL
Cwoe_0137 ADB48573 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_0186 ADB48622 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_0829 ADB49262 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_1211 ADB49640 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_1244 ADB49673 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_1770 ADB50197 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Cwoe_5546 ADB53951 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
GGDEF only
Cwoe_3143 ADB51562 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Cwoe_5253 ADB53659 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Cwoe_4732 ADB53145 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Corynebacterium glutamicum ATCC 13032
cg1179 CAF19741 GGDEF family protein [Cor... BLink CDD UniProt Pfam InterPro

Eggerthella lenta DSM 2243
GGDEF-EAL
Elen_0189 ACV54183 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_0281 ACV54272 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_0467 ACV54453 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_0735 ACV54714 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_1047 ACV55018 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_1086 ACV55057 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_1281 ACV55250 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_2229 ACV56190 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_2577 ACV56530 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Elen_2902 ACV56847 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Eggerthella sp. YY7918
GGDEF-EAL
EGYY_02910 BAK43526 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_03380 BAK43571 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_03540 BAK43587 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
EGYY_05350 BAK43748 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_07580 BAK43955 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_18140 BAK44949 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_18570 BAK44990 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_20010 BAK45094 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_22840 BAK45357 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_28340 BAK45811 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EGYY_28350 BAK45812 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro
EAL only
EGYY_16720 BAK44812 hypothetical protein EGYY... BLink CDD UniProt Pfam InterPro

Frankia alni ACN14a
GGDEF-EAL
FRAAL1639 CAJ60294 Putative sensory box/GGDE... BLink CDD UniProt Pfam InterPro
FRAAL1954 CAJ60603 hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL2035 CAJ60684 hypothetical protein FRAA... BLink CDD UniProt Pfam InterPro
FRAAL4612 CAJ63254 hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL5548 CAJ64181 hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL5824 CAJ64456 Hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL5972 CAJ64597 hypothetical protein FRAA... BLink CDD UniProt Pfam InterPro
EAL only
FRAAL3871 CAJ62514 putative regulatory prote... BLink CDD UniProt Pfam InterPro
FRAAL3921 CAJ62564 hypothetical protein FRAA... BLink CDD UniProt Pfam InterPro
FRAAL4051 CAJ62693 hypothetical protein FRAA... BLink CDD UniProt Pfam InterPro
FRAAL5708 CAJ64340 hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL5844 CAJ64476 hypothetical protein; put... BLink CDD UniProt Pfam InterPro
FRAAL6490 CAJ65113 hypothetical protein FRAA... BLink CDD UniProt Pfam InterPro

Frankia sp. CcI3
GGDEF-EAL
Francci3_0377 ABD09764 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Francci3_1004 ABD10387 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Francci3_1288 ABD10665 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Francci3_1622 ABD10998 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Francci3_3617 ABD12969 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Francci3_3740 ABD13091 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
EAL only
Francci3_2139 ABD11511 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Francci3_2421 ABD11788 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Francci3_3515 ABD12868 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Francci3_3633 ABD12985 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro

Frankia sp. EAN1pec
GGDEF-EAL
Franean1_0510 ABW09971 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_0996 ABW10452 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_1083 ABW10539 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_1119 ABW10573 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_2044 ABW11481 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_2140 ABW11576 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_2284 ABW11719 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_2342 ABW11776 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_2685 ABW12111 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_3744 ABW13139 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
Franean1_6421 ABW15758 diguanylate cyclase/ph... BLink CDD UniProt Pfam InterPro
EAL only
Franean1_0378 ABW09844 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_1097 ABW10553 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_1229 ABW10683 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_2526 ABW11957 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_3112 ABW12524 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_3883 ABW13274 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_4110 ABW13497 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro
Franean1_4968 ABW14332 diguanylate phosphodie... BLink CDD UniProt Pfam InterPro

Frankia sp. EuI1c
GGDEF-EAL
FraEuI1c_0832 ADP78910 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_1405 ADP79472 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_2233 ADP80272 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_3293 ADP81305 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_3496 ADP81505 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_4024 ADP82027 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_4288 ADP82287 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_4620 ADP82613 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_4795 ADP82785 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_4915 ADP82905 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_5042 ADP83031 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_5044 ADP83033 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
FraEuI1c_6459 ADP84440 diguanylate cyclase/p... BLink CDD UniProt Pfam InterPro
EAL only
FraEuI1c_0488 ADP78571 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_0917 ADP78990 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_1041 ADP79114 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_1145 ADP79218 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_3169 ADP81186 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_4290 ADP82289 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_5049 ADP83038 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_5977 ADP83961 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_6718 ADP84687 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro
FraEuI1c_7078 ADP85043 diguanylate phosphodi... BLink CDD UniProt Pfam InterPro

Frankia symbiont of Datisca glomerata
GGDEF-EAL
FsymDg_0166 AEH07739 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_0275 AEH07847 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_1237 AEH08727 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_1452 AEH08919 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_2136 AEH09548 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_2619 AEH09976 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_3012 AEH10329 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_3579 AEH10858 unnamed protein product... BLink CDD UniProt Pfam InterPro
EAL only
FsymDg_3756 AEH11033 unnamed protein product... BLink CDD UniProt Pfam InterPro
FsymDg_3603 AEH10882 unnamed protein product... BLink CDD UniProt Pfam InterPro

Geodermatophilus obscurus DSM 43160
GGDEF-EAL
Gobs_0071 ADB72881 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_0076 ADB72886 PAS/PAC and GAF sensor-co... BLink CDD UniProt Pfam InterPro
Gobs_1231 ADB73977 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Gobs_1491 ADB74220 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_1777 ADB74487 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Gobs_2175 ADB74858 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_3082 ADB75691 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Gobs_3368 ADB75970 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Gobs_3750 ADB76328 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_4074 ADB76639 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_4075 ADB76640 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Gobs_4532 ADB77082 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Gobs_4973 ADB77502 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Gobs_0137 ADB72943 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Gobs_0300 ADB73102 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Gobs_1371 ADB74106 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Gobs_4614 ADB77162 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Gordonia bronchialis DSM 43247
EAL only
Gbro_1083 ACY20392 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro
*Gbro_0217 ACY19564 EAL domain-containing pro... BLink CDD UniProt Pfam InterPro

Gordonia polyisoprenivorans VH2
EAL only
GPOL_c11510 AFA72213 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
GPOL_c11550 AFA72217 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro
GPOL_c35310 AFA74543 putative diguanylate pho... BLink CDD UniProt Pfam InterPro
*GPOL_c04210 AFA71492 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro

Gordonia sp. KTR9
GGDEF-EAL
KTR9_2499 AFR49136 putative signal transduct... BLink CDD UniProt Pfam InterPro
EAL only
KTR9_0954 AFR47599 EAL superfamily protein [... BLink CDD UniProt Pfam InterPro

Kineococcus radiotolerans SRS30216
GGDEF-EAL
Krad_0088 ABS01579 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0179 ABS01670 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0235 ABS01725 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0246 ABS01736 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0341 ABS01831 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0351 ABS01841 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0356 ABS01846 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0369 ABS01859 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0510 ABS01999 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0523 ABS02012 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0606 ABS02095 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0638 ABS02127 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0639 ABS02128 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_0950 ABS02438 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_1026 ABS02514 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_1029 ABS02517 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_1568 ABS03054 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_1612 ABS03098 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_1934 ABS03420 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2008 ABS03493 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2022 ABS03507 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2200 ABS03683 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2444 ABS03923 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2587 ABS04061 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_2761 ABS04233 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_3544 ABS05007 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_3586 ABS05049 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_3696 ABS05159 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_3808 ABS05271 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_3943 ABS05406 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_4307 ABS05770 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_4323 ABS05786 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_4364 ABS05827 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_4462 ABS05921 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Krad_4463 ABS05922 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Krad_0326 ABS01816 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_1006 ABS02494 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_1803 ABS03289 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_1983 ABS03469 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_2010 ABS03495 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_2441 ABS03920 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_2585 ABS04059 putative diguanylate phos... BLink CDD UniProt Pfam InterPro
Krad_4158 ABS05621 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Krad_4244 ABS05707 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Kitasatospora setae KM-6054
GGDEF-EAL
KSE_27850 BAJ28596 unnamed protein product... BLink CDD UniProt Pfam InterPro
KSE_51100 BAJ30888 unnamed protein product... BLink CDD UniProt Pfam InterPro
KSE_51170 BAJ30895 unnamed protein product... BLink CDD UniProt Pfam InterPro
KSE_64660 BAJ32225 unnamed protein product... BLink CDD UniProt Pfam InterPro

Micromonospora aurantiaca ATCC 27029
GGDEF-EAL
Micau_0934 ADL44498 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_1063 ADL44625 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_1266 ADL44828 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_1277 ADL44839 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_1300 ADL44862 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_1441 ADL45001 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_4552 ADL48064 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_5548 ADL49054 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro
Micau_6257 ADL49750 diguanylate cyclase [Mic... BLink CDD UniProt Pfam InterPro

Micromonospora sp. L5
GGDEF-EAL
ML5_0640 ADU06190 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1182 ADU06721 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1312 ADU06851 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1522 ADU07059 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1533 ADU07070 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1547 ADU07083 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_1700 ADU07232 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_3751 ADU09262 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
ML5_6219 ADU11662 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Modestobacter marinus str. BC501
GGDEF-EAL
MODMU_0401 CCH85859 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_0402 CCH85860 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_0716 CCH86169 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
MODMU_0856 CCH86306 diguanylate kinase [Modes... BLink CDD UniProt Pfam InterPro
MODMU_1233 CCH86683 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
MODMU_1476 CCH86925 PAS domain S-box/diguanyl... BLink CDD UniProt Pfam InterPro
MODMU_1885 CCH87322 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_2127 CCH87562 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_3222 CCH88635 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_3255 CCH88668 diguanylate kinase [Modes... BLink CDD UniProt Pfam InterPro
MODMU_3770 CCH89177 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_3779 CCH89184 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_4481 CCH89864 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_4482 CCH89865 diguanylate cyclase [Mode... BLink CDD UniProt Pfam InterPro
MODMU_4943 CCH90323 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
MODMU_4976 CCH90356 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_5040 CCH90420 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
MODMU_0157 CCH85629 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_0317 CCH85779 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
MODMU_0393 CCH85851 signal-transducer protein... BLink CDD UniProt Pfam InterPro
MODMU_1269 CCH86719 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_1414 CCH86863 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
MODMU_1920 CCH87356 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_2001 CCH87436 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
MODMU_3839 CCH89243 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
MODMU_3851 CCH89255 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
MODMU_4531 CCH89914 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Mycobacterium africanum GM041182
GGDEF-EAL
MAF_13780 CCC26450 unnamed protein product ... BLink CDD UniProt Pfam InterPro
EAL only
MAF_13810 CCC26453 unnamed protein product ... BLink CDD UniProt Pfam InterPro

Mycobacterium avium subsp. paratuberculosis str. k10
GGDEF-EAL
MAP0949 AAS03266 hypothetical protein MAP0... BLink CDD UniProt Pfam InterPro
MAP1346c AAS03663 hypothetical protein MAP1... BLink CDD UniProt Pfam InterPro
MAP2512 AAS04829 hypothetical protein MAP2... BLink CDD UniProt Pfam InterPro

Mycobacterium bovis AF2122/97
Mb1389c CDO42636 hypothetical protein Mb1... BLink CDD UniProt Pfam InterPro
Mb1392c CDO42639 hypothetical protein Mb1... BLink CDD UniProt Pfam InterPro

Mycobacterium canettii CIPT 140010059
GGDEF-EAL
MCAN_13721 CCC43704 unnamed protein product... BLink CDD UniProt Pfam InterPro
EAL only
MCAN_13751 CCC43707 unnamed protein product... BLink CDD UniProt Pfam InterPro

Mycobacterium chubuense NBB4
GGDEF-EAL
Mycch_1564 AFM16363 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mycch_1711 AFM16502 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro
Mycch_2255 AFM17032 diguanylate cyclase (GGDE... BLink CDD UniProt Pfam InterPro

Mycobacterium gilvum PYR-GCK
GGDEF-EAL
Mflv_0999 ABP43482 response regulator receiv... BLink CDD UniProt Pfam InterPro
Mflv_1781 ABP44261 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_2073 ABP44551 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_2740 ABP45217 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_3478 ABP45953 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_4377 ABP46846 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_4444 ABP46913 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mflv_5174 ABP47640 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Mflv_1320 ABP43802 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
Mflv_4571 ABP47039 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Mycobacterium indicus pranii MTCC 9506
GGDEF-EAL
MIP_01652 AFS13140 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
MIP_02104 AFS13446 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
MIP_04379 AFS14984 diguanylate cyclase [Myco... BLink CDD UniProt Pfam InterPro

Mycobacterium intracellulare ATCC 13950
GGDEF-EAL
OCU_10050 AFC42225 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
OCU_15570 AFC42776 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
OCU_29630 AFC44182 diguanylate cyclase [Myco... BLink CDD UniProt Pfam InterPro

Mycobacterium leprae TN
ML1750 CAC30703 hypothetical protein ML17... BLink CDD UniProt Pfam InterPro
ML1752 CAC30705 hypothetical protein ML17... BLink CDD UniProt Pfam InterPro

Mycobacterium rhodesiae NBB31760> taxid
GGDEF-EAL
MycrhN_0214 AEV70857 diguanylate cyclase doma... BLink CDD UniProt Pfam InterPro
MycrhN_3454 AEV73974 diguanylate cyclase doma... BLink CDD UniProt Pfam InterPro

Mycobacterium smegmatis str. MC2 155
MSMEG_2196 ABK69623 sensory box/response regu... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. JDM601
JDM601_1583 AEF35583 hypothetical protein JDM... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. JLS
GGDEF-EAL
Mjls_1586 ABN97384 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mjls_1729 ABN97519 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mjls_2204 ABN97990 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mjls_5133 ABO00898 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. KMS
GGDEF-EAL
Mkms_1640 ABL90847 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mkms_1795 ABL90996 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mkms_2261 ABL91459 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mkms_4833 ABL94023 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. MCS
GGDEF-EAL
Mmcs_1615 ABG07726 GGDEF:EAL [Mycobacterium ... BLink CDD UniProt Pfam InterPro
Mmcs_1748 ABG07857 GGDEF:EAL:GAF [Mycobacter... BLink CDD UniProt Pfam InterPro
Mmcs_2215 ABG08323 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mmcs_4747 ABG10851 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. MOTT36Y
GGDEF-EAL
W7S_05000 AFJ33983 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
W7S_06375 AFJ34258 cyclic diguanylate phosph... BLink CDD UniProt Pfam InterPro
W7S_14760 AFJ35917 diguanylate cyclase [Myco... BLink CDD UniProt Pfam InterPro

Mycobacterium sp. Spyr1
GGDEF-EAL
Mspyr1_11650 ADT97847 diguanylate cyclase (GG... BLink CDD UniProt Pfam InterPro
Mspyr1_14970 ADT98168 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
Mspyr1_21780 ADT98828 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
Mspyr1_28150 ADT99443 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
Mspyr1_37260 ADU00332 diguanylate cyclase (GG... BLink CDD UniProt Pfam InterPro
Mspyr1_38430 ADU00437 diguanylate cyclase/pho... BLink CDD UniProt Pfam InterPro
Mspyr1_45940 ADU01146 PAS domain S-box/diguan... BLink CDD UniProt Pfam InterPro
Mspyr1_51910 ADU01718 PAS domain S-box/diguan... BLink CDD UniProt Pfam InterPro
EAL only
Mspyr1_39710 ADU00561 EAL domain-containing p... BLink CDD UniProt Pfam InterPro
Mspyr1_48590 ADU01397 EAL domain-containing p... BLink CDD UniProt Pfam InterPro

Mycobacterium tuberculosis H37Rv
GGDEF-EAL
Rv1354c AAK45660 hypothetical protein Rv13... BLink CDD UniProt Pfam InterPro
EAL only
Rv1357c AAK45663 hypothetical protein Rv13... BLink CDD UniProt Pfam InterPro

Mycobacterium vanbaalenii PYR-1
GGDEF-EAL
Mvan_1152 ABM11987 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mvan_1918 ABM12738 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mvan_1967 ABM12786 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Mvan_4640 ABM15415 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Mvan_1667 ABM12496 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Nakamurella multipartita DSM 44233
GGDEF-EAL
Namu_0203 ACV76636 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Namu_1007 ACV77416 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Namu_4044 ACV80336 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Namu_5214 ACV81480 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Namu_5244 ACV81510 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Namu_5305 ACV81571 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Nocardia brasiliensis ATCC 700358
GGDEF-EAL
O3I_000510 AFT98064 hypothetical protein O3I... BLink CDD UniProt Pfam InterPro
O3I_008250 AFT99612 PAS/PAC sensor(s)-contai... BLink CDD UniProt Pfam InterPro
O3I_023990 AFU02753 sensory box/GGDEF protei... BLink CDD UniProt Pfam InterPro
O3I_037165 AFU05380 hypothetical protein O3I... BLink CDD UniProt Pfam InterPro

Nocardia cyriacigeorgica GUH-2
GGDEF-EAL
NOCYR_0106 CCF60930 hypothetical protein NOCY... BLink CDD UniProt Pfam InterPro
NOCYR_4701 CCF65456 GAF sensor-containing dig... BLink CDD UniProt Pfam InterPro

Nocardia farcinica IFM 10152
GGDEF-EAL
nfa1410 BAD54983 hypothetical protein nfa1... BLink CDD UniProt Pfam InterPro
nfa49160 BAD59768 hypothetical protein nfa4... BLink CDD UniProt Pfam InterPro

Nocardioides sp. JS614
GGDEF-EAL
Noca_1138 ABL80654 diguanylate cyclase [Noca... BLink CDD UniProt Pfam InterPro
Noca_1139 ABL80655 diguanylate cyclase [Noca... BLink CDD UniProt Pfam InterPro

Nocardiopsis alba ATCC BAA-2165
GGDEF-EAL
B005_2982 AFR07392 diguanylate cyclase domai... BLink CDD UniProt Pfam InterPro
B005_2996 AFR10478 diguanylate cyclase domai... BLink CDD UniProt Pfam InterPro
EAL only
B005_5492 AFR07173 EAL domain protein [Nocar... BLink CDD UniProt Pfam InterPro

Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
GGDEF-EAL
Ndas_0161 ADH65611 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Ndas_0170 ADH65620 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Ndas_2953 ADH68363 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Pseudonocardia dioxanivorans CB1190
GGDEF-EAL
Psed_0440 AEA22708 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Psed_4081 AEA26244 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
Psed_5134 AEA27271 PAS/PAC sensor-containing... BLink CDD UniProt Pfam InterPro
EAL only
Psed_0957 AEA23209 diguanylate cyclase [Pseu... BLink CDD UniProt Pfam InterPro

Rhodococcus equi 103S
EAL only
REQ_25480 CBH48585 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro
*REQ_25471 CBH48584 hypothetical protein REQ_... BLink CDD UniProt Pfam InterPro

Rhodococcus erythropolis PR4
GGDEF-EAL
RER_01350 BAH30843 hypothetical protein RER_... BLink CDD UniProt Pfam InterPro
RER_42750 BAH34983 hypothetical protein RER_... BLink CDD UniProt Pfam InterPro
RER_42760 BAH34984 hypothetical protein RER_... BLink CDD UniProt Pfam InterPro
RER_55690 BAH36277 hypothetical protein RER_... BLink CDD UniProt Pfam InterPro
EAL only
RER_03490 BAH31057 hypothetical protein RER_... BLink CDD UniProt Pfam InterPro

Rhodococcus jostii RHA1
GGDEF-EAL
RHA1_ro00511 ABG92347 hypothetical protein RH... BLink CDD UniProt Pfam InterPro
RHA1_ro05753 ABG97531 hypothetical protein RH... BLink CDD UniProt Pfam InterPro
RHA1_ro05772 ABG97550 hypothetical protein RH... BLink CDD UniProt Pfam InterPro

Rhodococcus opacus B4
GGDEF-EAL
ROP_58150 BAH54062 hypothetical protein ROP_... BLink CDD UniProt Pfam InterPro
ROP_58360 BAH54083 hypothetical protein ROP_... BLink CDD UniProt Pfam InterPro

Rubrobacter xylanophilus DSM 9941
GGDEF-EAL
Rxyl_0492 ABG03466 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Rxyl_1544 ABG04506 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Rxyl_2783 ABG05697 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Rxyl_1156 ABG04122 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Rxyl_2092 ABG05036 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Rxyl_2093 ABG05037 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Saccharomonospora viridis DSM 43017
GGDEF-EAL
Svir_03500 ACU95430 diguanylate cyclase (GGD... BLink CDD UniProt Pfam InterPro
Svir_16390 ACU96672 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro
Svir_37050 ACU98654 PAS domain S-box/diguany... BLink CDD UniProt Pfam InterPro

Saccharopolyspora erythraea NRRL 2338
GGDEF-EAL
SACE_0097 CAL99450 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
SACE_2003 CAM01313 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
SACE_2183 CAM01489 hypothetical protein SACE... BLink CDD UniProt Pfam InterPro
SACE_2846 CAM02125 two-component response re... BLink CDD UniProt Pfam InterPro
SACE_2969 CAM02247 PAS:GGDEF [Saccharopolysp... BLink CDD UniProt Pfam InterPro
SACE_3161 CAM02438 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
SACE_4370 CAM03639 sensory box protein [Sacc... BLink CDD UniProt Pfam InterPro
SACE_5649 CAM04835 two component signal tran... BLink CDD UniProt Pfam InterPro
SACE_6414 CAM05584 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
SACE_6878 CAM06042 hypothetical protein SACE... BLink CDD UniProt Pfam InterPro
SACE_7137 CAM06295 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
SACE_4887 CAM04153 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Saccharothrix espanaensis DSM 44229
GGDEF-EAL
BN6_15520 CCH28876 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_34060 CCH30704 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_42980 CCH31581 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_62230 CCH33472 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_65510 CCH33789 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_73790 CCH34609 Signal transduction prote... BLink CDD UniProt Pfam InterPro
BN6_74790 CCH34706 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_75490 CCH34774 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_79770 CCH35195 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro
BN6_82430 CCH35460 putative diguanylate cycl... BLink CDD UniProt Pfam InterPro

Salinispora arenicola CNS-205
GGDEF-EAL
Sare_0870 ABV96788 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_1110 ABV97018 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_1122 ABV97030 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_1318 ABV97219 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_3513 ABV99315 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_4335 ABW00117 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sare_5060 ABW00804 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
EAL only
Sare_1503 ABV97400 diguanylate phosphodieste... BLink CDD UniProt Pfam InterPro

Salinispora tropica CNB-440
GGDEF-EAL
Strop_0927 ABP53404 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro
Strop_1218 ABP53688 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro
Strop_1232 ABP53702 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro
Strop_1361 ABP53828 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro
Strop_3281 ABP55715 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro
Strop_3943 ABP56373 diguanylate cyclase [Sali... BLink CDD UniProt Pfam InterPro

Slackia heliotrinireducens DSM 20476
GGDEF-EAL
Shel_24280 ACV23436 EAL domain-containing pr... BLink CDD UniProt Pfam InterPro

Stackebrandtia nassauensis DSM 44728
GGDEF-EAL
Snas_2366 ADD42051 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Snas_4358 ADD44005 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Snas_6367 ADD45983 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Streptomyces avermitilis MA-4680
GGDEF-EAL
SAV2734 BAC70445 putative integral membran... BLink CDD UniProt Pfam InterPro
SAV2747 BAC70458 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
SAV5237 BAC72949 putative sensory box/GGDE... BLink CDD UniProt Pfam InterPro
SAV6965 BAC74676 hypothetical protein [Str... BLink CDD UniProt Pfam InterPro
SAV7304 BAC75015 hypothetical protein [Str... BLink CDD UniProt Pfam InterPro

Streptomyces bingchenggensis BCW-1
GGDEF-EAL
SBI_02315 ADI05436 hypothetical protein SBI_... BLink CDD UniProt Pfam InterPro
SBI_03558 ADI06679 putative integral membran... BLink CDD UniProt Pfam InterPro
SBI_03576 ADI06697 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
SBI_06832 ADI09952 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro

Streptomyces cattleya NRRL 8057 = DSM 46488
GGDEF-EAL
SCAT_1884 CCB74603 unnamed protein product... BLink CDD UniProt Pfam InterPro
SCAT_4326 AEW96682 unnamed protein product... BLink CDD UniProt Pfam InterPro
SCAT_4336 CCB77032 unnamed protein product... BLink CDD UniProt Pfam InterPro

Streptomyces coelicolor A3(2)
GGDEF-EAL
SCO0928 CAB63177 conserved hypothetical pr... BLink CDD UniProt Pfam InterPro
SCO2817 CAC44280 conserved hypothetical pr... BLink CDD UniProt Pfam InterPro
SCO5495 CAB37571 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
SCO5511 CAB37587 putative membrane associa... BLink CDD UniProt Pfam InterPro
EAL only
*SCO1397 CAB88893 hypothetical protein [Str... BLink CDD UniProt Pfam InterPro

Streptomyces flavogriseus ATCC 33331
GGDEF-EAL
Sfla_0419 ADW01885 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sfla_1827 ADW03261 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sfla_1841 ADW03275 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Sfla_4076 ADW05488 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Streptomyces griseus subsp. griseus NBRC 13350
GGDEF-EAL
SGR_709 BAG17538 hypothetical protein SGR_... BLink CDD UniProt Pfam InterPro
SGR_2001 BAG18830 putative integral membran... BLink CDD UniProt Pfam InterPro
SGR_2020 BAG18849 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
SGR_4717 BAG21546 hypothetical protein SGR_... BLink CDD UniProt Pfam InterPro

Streptomyces hygroscopicus subsp. jinggangensis 5008
GGDEF-EAL
SHJG_4317 AEY89589 sensory box/GGDEF family ... BLink CDD UniProt Pfam InterPro
SHJG_6587 AEY91854 phosphodiesterase [Strept... BLink CDD UniProt Pfam InterPro
SHJG_6607 AEY91874 integral membrane phospho... BLink CDD UniProt Pfam InterPro
SHJG_7877 AEY93144 hypothetical protein SHJG... BLink CDD UniProt Pfam InterPro

Streptomyces scabiei 87.22
GGDEF-EAL
SCAB_11501 CBG68318 hypothetical protein SCA... BLink CDD UniProt Pfam InterPro
SCAB_27101 CBG69812 membrane associated phop... BLink CDD UniProt Pfam InterPro
SCAB_27241 CBG69826 membrane-associated phos... BLink CDD UniProt Pfam InterPro
SCAB_57501 CBG72776 diguanylate cyclase [Str... BLink CDD UniProt Pfam InterPro

Streptomyces sp. SirexAA-E
GGDEF-EAL
SACTE_2305 AEN10196 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
SACTE_4697 AEN12523 diguanylate cyclase/phos... BLink CDD UniProt Pfam InterPro
SACTE_4711 AEN12537 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro
SACTE_6210 AEN13985 PAS/PAC sensor-containin... BLink CDD UniProt Pfam InterPro

Streptomyces venezuelae ATCC 10712
GGDEF-EAL
SVEN_0451 CCA53738 8-amino-7-oxononanoate sy... BLink CDD UniProt Pfam InterPro
SVEN_2604 CCA55890 putative sensory box or G... BLink CDD UniProt Pfam InterPro
SVEN_5165 CCA58451 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
SVEN_5187 CCA58473 Sensory box or GGDEF fami... BLink CDD UniProt Pfam InterPro
SVEN_6830 CCA60116 Sensory box or GGDEF fami... BLink CDD UniProt Pfam InterPro

Streptomyces violaceusniger Tu 4113
GGDEF-EAL
Strvi_1851 AEM81587 unnamed protein product... BLink CDD UniProt Pfam InterPro
Strvi_1863 AEM81599 unnamed protein product... BLink CDD UniProt Pfam InterPro
Strvi_3116 AEM82812 unnamed protein product... BLink CDD UniProt Pfam InterPro
Strvi_8164 AEM87486 unnamed protein product... BLink CDD UniProt Pfam InterPro
EAL only
*Strvi_4786 AEM84348 unnamed protein product... BLink CDD UniProt Pfam InterPro

Streptosporangium roseum DSM 43021
GGDEF-EAL
Sros_8060 ACZ90715 signal transduction prote... BLink CDD UniProt Pfam InterPro
Sros_8076 ACZ90731 signal transduction prote... BLink CDD UniProt Pfam InterPro
EAL only
Sros_5974 ACZ88709 putative diguanylate phos... BLink CDD UniProt Pfam InterPro

Thermobifida fusca YX
GGDEF-EAL
Tfu_0604 AAZ54642 putative phosphodiesteras... BLink CDD UniProt Pfam InterPro
Tfu_0610 AAZ54648 PAS:GGDEF [Thermobifida f... BLink CDD UniProt Pfam InterPro
EAL only
Tfu_1977 AAZ56010 EAL domain [Thermobifida ... BLink CDD UniProt Pfam InterPro

Thermobispora bispora DSM 43833
GGDEF-EAL
Tbis_2822 ADG89521 PAS/PAC sensor domain-con... BLink CDD UniProt Pfam InterPro
Tbis_2829 ADG89528 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Thermomonospora curvata DSM 43183
GGDEF-EAL
Tcur_3555 ACY99090 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro
Tcur_3562 ACY99097 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Tsukamurella paurometabola DSM 20162
Tpau_2112 ADG78723 diguanylate cyclase/phosp... BLink CDD UniProt Pfam InterPro

Verrucosispora maris AB-18-032
GGDEF-EAL
VAB18032_01255 AEB47335 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_04270 AEB47936 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_09375 AEB42993 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_09915 AEB43101 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_11085 AEB43335 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_11135 AEB43345 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_11190 AEB43356 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_11795 AEB43473 unnamed protein prot... BLink CDD UniProt Pfam InterPro
VAB18032_27141 AEB46501 unnamed protein prot... BLink CDD UniProt Pfam InterPro
Please send corrections, questions and comments to Michael Galperin