doi: 10.1136/bmj.1.6126.1515.
Early deaths in Jamaican children with sickle cell disease
- PMID: 656779
- PMCID: PMC1605039
- DOI: 10.1136/bmj.1.6126.1515
Item in Clipboard
Early deaths in Jamaican children with sickle cell disease
Br Med J.
.
Abstract
In Jamaican children with homozygous sickle cell (SS) disease diagnosed at birth two-year survival was 87%, compared with 95% in children with sickle cell-haemoglobin C (CS) disease, and 99% in normal controls. Death among those with SS disease occurred most often between the ages of 6 and 12 months. Principal causes were acute splenic sequestration and pneumococcal infection. Neonatal diagnosis of haemoglobinopathies must be followed by close observation if mortality is to be reduced by early diagnosis and treatment of these complications.
Similar articles
-
Newborn sickle cell disease screening: the Jamaican experience (1995-2006).J Med Screen. 2007;14(3):117-22. doi: 10.1258/096914107782066185. J Med Screen. 2007. PMID: 17925083
-
Causes of death and early life determinants of survival in homozygous sickle cell disease: The Jamaican cohort study from birth.PLoS One. 2018 Mar 1;13(3):e0192710. doi: 10.1371/journal.pone.0192710. eCollection 2018. PLoS One. 2018. PMID: 29494636 Free PMC article.
-
Improved survival in homozygous sickle cell disease: lessons from a cohort study.BMJ. 1995 Dec 16;311(7020):1600-2. doi: 10.1136/bmj.311.7020.1600. BMJ. 1995. PMID: 8555802 Free PMC article.
-
Management of sickle cell disease; lessons from the Jamaican Cohort Study.Blood Rev. 1993 Sep;7(3):137-45. doi: 10.1016/0268-960x(93)90001-k. Blood Rev. 1993. PMID: 8241829 Review.
-
Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.Cochrane Database Syst Rev. 2012 Sep 12;(9):CD003427. doi: 10.1002/14651858.CD003427.pub2. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2014 Nov 06;(11):CD003427. doi: 10.1002/14651858.CD003427.pub3. PMID: 22972063 Updated. Review.
Cited by
-
Partial splenectomy in sickle cell syndromes.Arch Dis Child. 1991 Sep;66(9):1070-2. doi: 10.1136/adc.66.9.1070. Arch Dis Child. 1991. PMID: 1929516 Free PMC article.
-
Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil.Hematol Transfus Cell Ther. 2018 Jan-Mar;40(1):37-42. doi: 10.1016/j.bjhh.2017.09.006. Epub 2017 Dec 6. Hematol Transfus Cell Ther. 2018. PMID: 29519371 Free PMC article.
-
Hydroxyurea (hydroxycarbamide) for sickle cell disease.Cochrane Database Syst Rev. 2017 Apr 20;4(4):CD002202. doi: 10.1002/14651858.CD002202.pub2. Cochrane Database Syst Rev. 2017. Update in: Cochrane Database Syst Rev. 2022 Sep 1;9:CD002202. doi: 10.1002/14651858.CD002202.pub3. PMID: 28426137 Free PMC article. Updated. Review.
-
The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease.Front Immunol. 2021 Jan 27;11:561917. doi: 10.3389/fimmu.2020.561917. eCollection 2020. Front Immunol. 2021. PMID: 33584641 Free PMC article. Review.
-
Management of sickle cell disease.Postgrad Med J. 1987 Aug;63(742):605-9. doi: 10.1136/pgmj.63.742.605. Postgrad Med J. 1987. PMID: 3321006 Free PMC article. Review. No abstract available.
References
MeSH terms
LinkOut - more resources
Full Text Sources