Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 May 16;10(10):e31229.
doi: 10.1016/j.heliyon.2024.e31229. eCollection 2024 May 30.

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

Anu Chaudhary  1 , Rina Das  1 , Kiran Mehta  2 , Dinesh Kumar Mehta  1
Affiliations
Review

Indian herb Tinospora cordifolia and Tinospora species: Phytochemical and therapeutic application

Anu Chaudhary et al. Heliyon. .

Abstract

Clinical investigations are increasingly focusing on natural materials with medical benefits because, in contrast to medicines, they have extremely few adverse effects. Tinospora species of the Menispermaceae family has many bioactive principles for plant nutraceuticals. A thorough assessment of the existing literature revealed that Indian Tinospora species are an important group of medicinal herbs used for a variety of pharmacological activities. While, Tinospora cordifolia is widely recognized as a significant herb in the Indian System of Medicines (ISM) due to its bioactive components and has been used in the treatment of diabetes, cancer, urinary problems, fever, jaundice, helminthiasis, leprosy, dysentery, skin diseases, and many more. Using the search phrases "phytochemistry," "traditional uses," and "pharmacological evaluation of Indian Tinospora species," appropriate articles were carefully extracted from the MEDLINE/PubMed, Scopus, and WOS databases. Around 180 articles, related to the India Tinospora species, were selected from a pool of 200 papers published between 1991 and 2023. T. cordifolia has received a lot of scientific attention because of its diverse therapeutic characteristics in treating various diseases. Our present study in this review encompasses 1.) Phytochemistry, traditional uses and pharmacological potential of T. cordifolia as well as other Indian Tinospora species. 2.) Safety and toxicity study and available marketed formulation of T. cordifolia for the treatment of various diseases. The chemical constitution and pharmacological characteristics of other Tinospora species must also be investigated, indicating a need for further scientific research.

Keywords: Pharmacological; Phytochemistry; Safety; Tinospora cordifolia; Tinospora species (Menispermaceae); Toxicity.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
T. cordifolia.
Fig. 2
Fig. 2
Steroids of T. cordifolia, T. sinensis.
Fig. 3
Fig. 3
Alkaloids isolated from T. cordifolia, T. crispa and T. sinensis.
Fig. 4
Fig. 4
Glycosides of T. cordifolia and T. crispa and T. sinensis.
Fig. 4
Fig. 4
Glycosides of T. cordifolia and T. crispa and T. sinensis.
Fig. 5
Fig. 5
Terpenoids, Diterpenoid lactones and Sesquiterpenoids of T. cordifolia.
Fig. 6
Fig. 6
Flavonoids of T. crispa.
Fig. 7
Fig. 7
Clerodane type diterpenoids of T. baenzigeri and T. crisp.
Fig. 8
Fig. 8
Aliphatic compounds of T. crispa.
Fig. 9
Fig. 9
Miscellaneous compounds isolated from T. cordifolia.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Olabiyi A.S., Nkemehule F.E., Odukoya O.A., Samuel T.A., Ogbonnia S.O. Inhibition of glycosylation as an index of activity in plants with antidiabetic potentials. Biochem. Pharmacol. 2013;2:181.
    1. Wilken R., Veena M.S., Wang M.B., Srivatsan E.S. Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer. 2011;10:27–49. doi: 10.1186/1476-4598-10-12. - DOI - PMC - PubMed
    1. Singletary K. Turmeric: an overview of potential health benefits. Nutr. Today. 2010;45:216–225.
    1. Niraj S., Varsha S. A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19. Plant Science Today. 2020;7:417–423.
    1. Udayan P.S., Pradeep A.K., Balachandran I. A new species of tinospora (Menispermaceae) from South India. Edinb. J. Bot. 2009;66:77–80.

LinkOut - more resources