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Review
. 2024 Mar;1871(3):119676.
doi: 10.1016/j.bbamcr.2024.119676. Epub 2024 Jan 17.

Unraveling the interplay between vital organelle stress and oxidative stress in idiopathic pulmonary fibrosis

Anushree Mohanan  1 , Kaveri R Washimkar  2 , Madhav Nilakanth Mugale  3
Affiliations
Free article
Review

Unraveling the interplay between vital organelle stress and oxidative stress in idiopathic pulmonary fibrosis

Anushree Mohanan et al. Biochim Biophys Acta Mol Cell Res. 2024 Mar.
Free article

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by excessive accumulation of extracellular matrix, leading to irreversible fibrosis. Emerging evidence suggests that endoplasmic reticulum (ER) stress, mitochondrial stress, and oxidative stress pathways play crucial roles in the pathogenesis of IPF. ER stress occurs when the protein folding capacity of the ER is overwhelmed, triggering the unfolded protein response (UPR) and contributing to protein misfolding and cellular stress in IPF. Concurrently, mitochondrial dysfunction involving dysregulation of key regulators, including PTEN-induced putative kinase 1 (PINK1), Parkin, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and sirtuin 3 (SIRT3), disrupts mitochondrial homeostasis and impairs cellular energy metabolism. This leads to increased reactive oxygen species (ROS) production, release of pro-fibrotic mediators, and activation of fibrotic pathways, exacerbating IPF progression. The UPR-induced ER stress further disrupts mitochondrial metabolism, resulting in altered mitochondrial mechanisms that increase the generation of ROS, resulting in further ER stress, creating a feedback loop that contributes to the progression of IPF. Oxidative stress also plays a pivotal role in IPF, as ROS-mediated activation of TGF-β, NF-κB, and MAPK pathways promotes inflammation and fibrotic responses. This review mainly focuses on the links between ER stress, mitochondrial dysfunctions, and oxidative stress with different signaling pathways involved in IPF. Understanding these mechanisms and targeting key molecules within these pathways may offer promising avenues for intervention.

Keywords: Endoplasmic reticulum stress; Idiopathic pulmonary fibrosis; Mitochondrial dysfunction; Oxidative stress; Signaling pathways; Unfolded protein response.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interests.

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