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. 2023 Dec;513(1):350-354.
doi: 10.1134/S1607672923700515. Epub 2023 Dec 8.

Anti-aging Effect of Rutin in Caenorhabditis elegans and D-Gal-Induced Aging Mouse Model

Liang Xinghua  1 , Han Yingying  2 , Wang Shuai  1 , Lang Guangping  3
Affiliations

Anti-aging Effect of Rutin in Caenorhabditis elegans and D-Gal-Induced Aging Mouse Model

Liang Xinghua et al. Dokl Biochem Biophys. 2023 Dec.

Abstract

Caenorhabditis elegans and D-Gal-induced aging mouse model were used to investigate the anti-aging effect of rutin. The effects of different concentrations of rutin (0, 12.5, 25, and 50 μg/mL) on locomotor behavior, reproductive rate, and lifespan of C. elegans were determined. For establishing the aging mouse model, D-Gal (200 mg/kg) was subcutaneously injected into the back of mice, and mice were treated with rutin (200 mg/kg). At the end of treatment, memory and motor function was assessed by nest building test, open field test, and Y-maze. Serum and brain tissue were collected from each mouse to examine the ROS, lipofuscin, MDA, GSH-Px, and SOD levels. The results showed that rutin prolonged the lifespan of C. elegans, and increased the number of eggs of C. elegans (p < 0.05). In addition, rutin significantly improved the exercise capacity in mice (p < 0.05) and significantly reduced brain tissue ROS (p < 0.05) and MDA (p < 0.01) levels. Meanwhile, rutin could enhance the activity of SOD (p < 0.05) and GSH-Px (p < 0.01) significantly in the serum and brain. In summary, rutin exhibits anti-senescence capabilities which could be ascribed to its antioxidant activities.

Keywords: Caenorhabditis elegans; D-Gal; aging; oxidative stress; rutin.

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References

REFERENCES

    1. Kanoi, R., Loachan, P., Das, S., et al., Mangiferin, a naturally occurring polyphenol, mitigates oxidative stress induced premature senescence in human dermal fibroblast cells, Mol. Biol. Rep., 2021, vol. 48, no. 1, pp. 457–466. - DOI - PubMed
    1. Han, Z., Zhang, Z., Guan, Y., et al., New insights into vitamin C function: vitamin C induces JAK2 activation through its receptor-like transporter SVCT2, Int. J. Biol. Macromol., 2021, vol. 173, pp. 379–398. - DOI - PubMed
    1. Vigneron, A. and Vousden, K.H., p53, ROS, and senescence in the control of aging, Aging (Albany NY), 2010, vol. 2, no. 8, pp. 471–474. - DOI - PubMed - PMC
    1. Tursynbolat, S., Bakytkarim, Y., Huang, J., et al., Highly sensitive simultaneous electrochemical determination of myricetin and rutin via solid phase extraction on a ternary Pt@r-GO@MWCNTs nanocomposite, J. Pharm. Anal., 2019, vol. 9, no. 5, pp. 358–366. - DOI - PubMed - PMC
    1. Nkpaa, K.W. and Onyeso, G.I., Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation, and apoptosis in fluoride treated rats, Neurosci. Lett., 2018, vol. 682, pp. 92–99. - DOI - PubMed

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