Background: Ananas comosus L. (family Bromeliaceae) is a plant innate to South America and has been cultivated in various world regions. The plant parts have traditionally been used to treat various ailments, like cancer, diabetes mellitus, bacterial infection, Covid-19 infection, inflammation, arthritis, asthma, malaria, cardiovascular disease, and burn, as debridement agents. The pineapple contains nutrients, including vitamin C, iron, potassium, and protein. It also contains flavonoids, carotenoids, tannins, polyphenols, and alkaloids.

Methods: An extensive literature search was conducted on Ananas comosus using three scientific databases: PubMed, Scopus, and Web of Science. The keywords in this paper were combined to form a search strategy. Ananas comosus and pineapple were the main criteria for judging abstracts, titles, and keywords. In the full text of the paper, the secondary judgment criteria included mentioning "therapeutic potential" or "pharmacological activities". Among the 250 references in the compiled bibliography, there were original articles, books, and web addresses dating back to 2001 to 2023. A review of articles was conducted after abstracts and titles were screened, and 61 duplicate articles were deleted. In this paper, information is provided on the therapeutic potential and pharmacological actions of Ananas comosus and its bioactive compounds.

Results: In this review, the therapeutic potential of A. comosus has been detailed. The current review intends to provide an updated comprehensive overview of the versatile plant's use and its clinical trials.

Conclusion: The plant has gained enormous attention and increasing consideration for treating various diseases. The therapeutic potential of pineapple, its compound, extracts, and their mode of action are discussed briefly. Also, clinical trials are emphasized, which are in great demand and need further in-depth investigation in the future.