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. 2022 Oct;31(10):1101-1107.
doi: 10.1080/13543784.2022.2130750. Epub 2022 Oct 8.

Seladelpar: an investigational drug for the treatment of early-stage primary biliary cholangitis (PBC)

Aaron Wetten  1   2 , David Emrys Jeffreys Jones  1   2 , Jessica Katharine Dyson  1   2
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Free article

Seladelpar: an investigational drug for the treatment of early-stage primary biliary cholangitis (PBC)

Aaron Wetten et al. Expert Opin Investig Drugs. 2022 Oct.
Free article

Abstract

Introduction: Generic fibrates are used off-label as add-in therapy for the management of primary biliary cholangitis (PBC) but with unproven long-term liver-related survival benefits. The recently developed fibrate, seladelpar, has shown promising results in clinical trials, but these outcomes have been previously marred by safety concerns.

Areas covered: We summarize existing treatment options in PBC and evaluate current trial data for seladelpar in relation to liver biochemistry, symptomology, and safety.

Expert opinion: Seladelpar leads to marked improvement in liver biochemistry and may improve symptoms. Safety concerns around liver toxicity appear to have been addressed. With likely increasing evidence compared to existing off-label fibrates, seladelpar has the potential as an attractive future second-line agent in PBC.

Keywords: PPAR; Primary biliary cholangitis; fatigue; fibrates; peroxisome proliferator-activated receptor agonists; pruritus; seladelpar.

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