Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

doi:10.3390/life11040317

Review

. 2021 Apr 6;11(4):317.

doi: 10.3390/life11040317.

Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

Affiliations

¹ Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
² Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado 95115, Indonesia.
³ Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
⁴ Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan 90245, Indonesia.
⁵ Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
⁶ Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India.
⁷ Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
⁸ Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus, E32004 Ourense, Spain.
⁹ Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

PMID: 33917319
PMCID: PMC8067380
DOI: 10.3390/life11040317

Review

Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

Arka Jyoti Chakraborty et al. Life (Basel). 2021.

. 2021 Apr 6;11(4):317.

doi: 10.3390/life11040317.

Authors

Affiliations

¹ Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.
² Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sam Ratulangi, Manado 95115, Indonesia.
³ Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
⁴ Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan 90245, Indonesia.
⁵ Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
⁶ Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, India.
⁷ Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh.
⁸ Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo-Ourense Campus, E32004 Ourense, Spain.
⁹ Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.

PMID: 33917319
PMCID: PMC8067380
DOI: 10.3390/life11040317

Erratum in

Correction: Chakraborty et al. Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective. Life 2021, 11, 317.
Chakraborty AJ, Mitra S, Tallei TE, Tareq AM, Nainu F, Cicia D, Dhama K, Emran TB, Simal-Gandara J, Capasso R. Chakraborty AJ, et al. Life (Basel). 2024 Apr 7;14(4):483. doi: 10.3390/life14040483. Life (Basel). 2024. PMID: 38672810 Free PMC article.

Abstract

Bromelain is an effective chemoresponsive proteolytic enzyme derived from pineapple stems. It contains several thiol endopeptidases and is extracted and purified via several methods. It is most commonly used as an anti-inflammatory agent, though scientists have also discovered its potential as an anticancer and antimicrobial agent. It has been reported as having positive effects on the respiratory, digestive, and circulatory systems, and potentially on the immune system. It is a natural remedy for easing arthritis symptoms, including joint pain and stiffness. This review details bromelain's varied uses in healthcare, its low toxicity, and its relationship to nanoparticles. The door of infinite possibilities will be opened up if further extensive research is carried out on this pineapple-derived enzyme.

Keywords: Ananas comosus; bromelain; nanoparticles; pineapple; proteolytic enzymes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Overview of extraction and purification of bromelain.

**Figure 2**
Effect of bromelain in acute inflammation.

**Figure 3**
An overview of the significant therapeutic effects of bromelain.

See this image and copyright information in PMC

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References

1. Heinicke R.M., Gortner W.A. Stem bromelain—A new protease preparation from pineapple plants. Econ. Bot. 1957;11:225–234. doi: 10.1007/BF02860437. - DOI
1. Hatano K.I., Kojima M., Tanokura M., Takahashi K. Solution structure of bromelain inhibitor VI from pineapple stem: Structural similarity with Bowman—Birk trypsin/chymotrypsin inhibitor from soybean. Biochemistry. 1996;35:5379–5384. doi: 10.1021/bi952754+. - DOI - PubMed
1. Tayab M.A., Chowdhury K.A.A., Jabed M., Mohammed Tareq S., Kamal A.T.M.M., Islam M.N., Uddin A.M.K., Hossain M.A., Emran T.B., Simal-Gandara J. Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia. Plants. 2021;10:287. doi: 10.3390/plants10020287. - DOI - PMC - PubMed
1. Mamo J., Assefa F. Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus) Curr. Trends Biomed. Eng. Biosci. 2019;19:60–68.
1. Manzoor Z., Nawaz A., Mukhtar H., Haq I. Bromelain: Methods of Extraction, Purification and Therapeutic Applications. Braz. Arch. Biol. Technol. 2016;59:e16150010. doi: 10.1590/1678-4324-2016150010. - DOI

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[1] Heinicke R.M., Gortner W.A. Stem bromelain—A new protease preparation from pineapple plants. Econ. Bot. 1957;11:225–234. doi: 10.1007/BF02860437. - DOI

[2] Heinicke R.M., Gortner W.A. Stem bromelain—A new protease preparation from pineapple plants. Econ. Bot. 1957;11:225–234. doi: 10.1007/BF02860437. - DOI

[3] Hatano K.I., Kojima M., Tanokura M., Takahashi K. Solution structure of bromelain inhibitor VI from pineapple stem: Structural similarity with Bowman—Birk trypsin/chymotrypsin inhibitor from soybean. Biochemistry. 1996;35:5379–5384. doi: 10.1021/bi952754+. - DOI - PubMed

[4] Hatano K.I., Kojima M., Tanokura M., Takahashi K. Solution structure of bromelain inhibitor VI from pineapple stem: Structural similarity with Bowman—Birk trypsin/chymotrypsin inhibitor from soybean. Biochemistry. 1996;35:5379–5384. doi: 10.1021/bi952754+. - DOI - PubMed

[5] Tayab M.A., Chowdhury K.A.A., Jabed M., Mohammed Tareq S., Kamal A.T.M.M., Islam M.N., Uddin A.M.K., Hossain M.A., Emran T.B., Simal-Gandara J. Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia. Plants. 2021;10:287. doi: 10.3390/plants10020287. - DOI - PMC - PubMed

[6] Tayab M.A., Chowdhury K.A.A., Jabed M., Mohammed Tareq S., Kamal A.T.M.M., Islam M.N., Uddin A.M.K., Hossain M.A., Emran T.B., Simal-Gandara J. Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia. Plants. 2021;10:287. doi: 10.3390/plants10020287. - DOI - PMC - PubMed

[7] Mamo J., Assefa F. Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus) Curr. Trends Biomed. Eng. Biosci. 2019;19:60–68.

[8] Mamo J., Assefa F. Antibacterial and Anticancer Property of Bromelain: A Plant Protease Enzyme from Pineapples (Ananas comosus) Curr. Trends Biomed. Eng. Biosci. 2019;19:60–68.

[9] Manzoor Z., Nawaz A., Mukhtar H., Haq I. Bromelain: Methods of Extraction, Purification and Therapeutic Applications. Braz. Arch. Biol. Technol. 2016;59:e16150010. doi: 10.1590/1678-4324-2016150010. - DOI

[10] Manzoor Z., Nawaz A., Mukhtar H., Haq I. Bromelain: Methods of Extraction, Purification and Therapeutic Applications. Braz. Arch. Biol. Technol. 2016;59:e16150010. doi: 10.1590/1678-4324-2016150010. - DOI

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Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

Affiliations

Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

Authors

Affiliations

Erratum in

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Conflict of interest statement

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