Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms

doi:10.1002/hep.28950

Case Reports

. 2017 Mar;65(3):1065-1068.

doi: 10.1002/hep.28950. Epub 2017 Jan 6.

Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
² Ueno City General Hospital, Iga, Japan.
³ Tokyo Teishin Hospital, Tokyo, Japan.
⁴ Division of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.
⁵ Department of Gastroenterology and Hepatology, Japan Community Health Care Organization, Chukyo Hospital, Nagoya, Japan.

PMID: 27863442
PMCID: PMC5324621
DOI: 10.1002/hep.28950

Case Reports

Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms

Tatehiro Kagawa et al. Hepatology. 2017 Mar.

. 2017 Mar;65(3):1065-1068.

doi: 10.1002/hep.28950. Epub 2017 Jan 6.

Authors

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.
² Ueno City General Hospital, Iga, Japan.
³ Tokyo Teishin Hospital, Tokyo, Japan.
⁴ Division of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.
⁵ Department of Gastroenterology and Hepatology, Japan Community Health Care Organization, Chukyo Hospital, Nagoya, Japan.

PMID: 27863442
PMCID: PMC5324621
DOI: 10.1002/hep.28950

No abstract available

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Figures

**Figure 1**
Hepatic OATP1B3 protein expression in patients P1, P2, and P4 and a control. Positive staining for OATP1B3 is observed along the basolateral membrane of hepatocytes in centrilobular areas in control liver tissue (antibody HPA004943; Sigma‐Aldrich, St. Louis, MO). In contrast, OATP1B3 expression is not detected in any of the patients. Scale bar, 200 μm. Inset, high magnification.

See this image and copyright information in PMC

Comment in

Assessment of preoperative liver function based on indocyanine green clearance.
Kokudo T, Hasegawa K, Kokudo N. Kokudo T, et al. Hepatology. 2017 Aug;66(2):675-676. doi: 10.1002/hep.29232. Epub 2017 Jun 28. Hepatology. 2017. PMID: 28437858 No abstract available.
Reply.
Kagawa T, Adachi Y. Kagawa T, et al. Hepatology. 2017 Aug;66(2):676. doi: 10.1002/hep.29233. Epub 2017 Jun 28. Hepatology. 2017. PMID: 28437871 No abstract available.

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References

1. Namihisa T, Nambu M, Kobayashi N, Kuroda H. Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect. Hepatogastroenterology 1981;28:6‐12. - PubMed
1. van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012;122:519‐528. - PMC - PubMed
1. Kagawa T, Oka A, Kobayashi Y, Hiasa Y, Kitamura T, Sakugawa H, et al. Recessive inheritance of population‐specific intronic LINE‐1 insertion causes a Rotor syndrome phenotype. Hum Mutat 2015;36:327‐332. - PubMed
1. Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology 2015;61:260‐267. - PubMed
1. de Graaf W, Hausler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, et al. Transporters involved in the hepatic uptake of (99m)Tc‐mebrofenin and indocyanine green. J Hepatol 2011;54:738‐745. - PubMed

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[1] Namihisa T, Nambu M, Kobayashi N, Kuroda H. Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect. Hepatogastroenterology 1981;28:6‐12. - PubMed

[2] Namihisa T, Nambu M, Kobayashi N, Kuroda H. Nine cases with marked retention of indocyanine green test and normal sulfobromophthalein test without abnormal liver histology: constitutional indocyanine green excretory defect. Hepatogastroenterology 1981;28:6‐12. - PubMed

[3] van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012;122:519‐528. - PMC - PubMed

[4] van de Steeg E, Stranecky V, Hartmannova H, Noskova L, Hrebicek M, Wagenaar E, et al. Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest 2012;122:519‐528. - PMC - PubMed

[5] Kagawa T, Oka A, Kobayashi Y, Hiasa Y, Kitamura T, Sakugawa H, et al. Recessive inheritance of population‐specific intronic LINE‐1 insertion causes a Rotor syndrome phenotype. Hum Mutat 2015;36:327‐332. - PubMed

[6] Kagawa T, Oka A, Kobayashi Y, Hiasa Y, Kitamura T, Sakugawa H, et al. Recessive inheritance of population‐specific intronic LINE‐1 insertion causes a Rotor syndrome phenotype. Hum Mutat 2015;36:327‐332. - PubMed

[7] Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology 2015;61:260‐267. - PubMed

[8] Vaz FM, Paulusma CC, Huidekoper H, de Ru M, Lim C, Koster J, et al. Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology 2015;61:260‐267. - PubMed

[9] de Graaf W, Hausler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, et al. Transporters involved in the hepatic uptake of (99m)Tc‐mebrofenin and indocyanine green. J Hepatol 2011;54:738‐745. - PubMed

[10] de Graaf W, Hausler S, Heger M, van Ginhoven TM, van Cappellen G, Bennink RJ, et al. Transporters involved in the hepatic uptake of (99m)Tc‐mebrofenin and indocyanine green. J Hepatol 2011;54:738‐745. - PubMed

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Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms

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Loss of organic anion transporting polypeptide 1B3 function causes marked delay in indocyanine green clearance without any clinical symptoms

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