Upper gastrointestinal cancer in patients with familial adenomatous polyposis
- PMID: 2571019
- DOI: 10.1016/s0140-6736(89)90840-4
Upper gastrointestinal cancer in patients with familial adenomatous polyposis
Abstract
102 patients with familial adenomatous polyposis underwent upper gastrointestinal endoscopy as a screening test for gastroduodenal adenomas. 100 had duodenal abnormalities (dysplasia in 94, and hyperplasia in 6), usually in the second and third parts of the duodenum (91%). The periampullary area was abnormal in 87 of 97 patients who had a biopsy specimen taken from this site (dysplasia 72, hyperplasia 13, and inflammation 2). By contrast, gastric dysplasia was found in only 6 patients. Classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 had stage IV disease: these patients are at greatest risk of malignant change and require close surveillance. The pattern of dysplasia observed in the upper gastrointestinal tract resembled the pattern of mucosal exposure to bile.
Similar articles
-
Endoscopy and EUS are key for effective surveillance and management of duodenal adenomas in familial adenomatous polyposis.Gastrointest Endosc. 2015 Apr;81(4):960-6. doi: 10.1016/j.gie.2014.08.029. Epub 2014 Oct 24. Gastrointest Endosc. 2015. PMID: 25440680
-
Upper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102 patients.J Clin Pathol. 1990 Sep;43(9):738-43. doi: 10.1136/jcp.43.9.738. J Clin Pathol. 1990. PMID: 2170464 Free PMC article.
-
Progression and Management of Duodenal Neoplasia in Familial Adenomatous Polyposis: A Cohort Study.Ann Surg. 2015 Jun;261(6):1138-44. doi: 10.1097/SLA.0000000000000734. Ann Surg. 2015. PMID: 24950262
-
Gastroduodenal lesions in familial adenomatous polyposis.Surg Today. 2000;30(8):675-82. doi: 10.1007/s005950070077. Surg Today. 2000. PMID: 10955728 Review.
-
Upper gastrointestinal polyps in familial adenomatous polyposis.Hepatogastroenterology. 1999 Mar-Apr;46(26):667-9. Hepatogastroenterology. 1999. PMID: 10370594 Review.
Cited by
-
Familial adenomatous polyposis in pediatrics: natural history, emerging surveillance and management protocols, chemopreventive strategies, and areas of ongoing debate.Fam Cancer. 2016 Jul;15(3):477-85. doi: 10.1007/s10689-016-9905-5. Fam Cancer. 2016. PMID: 27056662
-
Gross and histological abnormalities of the foregut in familial adenomatous polyposis: a study from a South East Asian Registry.Int J Colorectal Dis. 1992 Dec;7(4):177-83. doi: 10.1007/BF00341216. Int J Colorectal Dis. 1992. PMID: 1338090
-
Guidelines for the management of patients with pancreatic cancer periampullary and ampullary carcinomas.Gut. 2005 Jun;54 Suppl 5(Suppl 5):v1-16. doi: 10.1136/gut.2004.057059. Gut. 2005. PMID: 15888770 Free PMC article. No abstract available.
-
Serrated adenoma of the duodenum.J Clin Pathol. 2004 Nov;57(11):1219-21. doi: 10.1136/jcp.2004.016360. J Clin Pathol. 2004. PMID: 15509689 Free PMC article.
-
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP.J Med Genet. 2007 Aug;44(8):541-4. doi: 10.1136/jmg.2007.049965. Epub 2007 May 11. J Med Genet. 2007. PMID: 17496195 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
