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. 2013 Oct 25:2:96.
doi: 10.1186/2046-4053-2-96.

Magnetic resonance spectroscopy as a prognostic marker in neonatal hypoxic-ischemic encephalopathy: a study protocol for an individual patient data meta-analysis

Pieter Lj Degraeuwe  1 , Gerald J Jaspers, Nicola J Robertson, Alfons Gh Kessels
Affiliations

Magnetic resonance spectroscopy as a prognostic marker in neonatal hypoxic-ischemic encephalopathy: a study protocol for an individual patient data meta-analysis

Pieter Lj Degraeuwe et al. Syst Rev. .

Abstract

Background: The prognostic accuracy of 1H (proton) magnetic resonance spectroscopy (MRS) in neonatal hypoxic-ischemic encephalopathy has been assessed by a criticized study-based meta-analysis. An individual patient data meta-analysis may overcome some of the drawbacks encountered in the aggregate data meta-analysis. Moreover, the prognostic marker can be assessed quantitatively and the effect of covariates can be estimated.

Methods: Diagnostic accuracy studies relevant to the study topic were retrieved. The primary authors will be invited to share the raw de-identified study data. These individual patient data will be analyzed using logistic regression analysis. A prediction tool calculating the individualized risk of very adverse outcome will be devised.

Discussion: The proposed individual patient data meta-analysis provides several advantages. Inclusion and exclusion criteria can be applied more uniformly. Furthermore, adjustment is possible for confounding factors and subgroup analyses can be conducted. Our goal is to develop a prediction model for outcome in newborns with hypoxic-ischemic encephalopathy.

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Figures

Figure 1
Figure 1
Flowchart showing search for and selection of papers evaluating prognostic value of 1H-MRS in neonatal hypoxic-ischemic encephalopathy. Final search carried out on 14 April 2012.
Figure 2
Figure 2
Results of quality assessment using QUADAS tool.
See this image and copyright information in PMC

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