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Review
. 2013 Jan;14(1):49-62.
doi: 10.1038/nrn3404. Epub 2012 Dec 12.

The Na(V)1.7 sodium channel: from molecule to man

Sulayman D Dib-Hajj  1 , Yang Yang, Joel A Black, Stephen G Waxman
Affiliations
Review

The Na(V)1.7 sodium channel: from molecule to man

Sulayman D Dib-Hajj et al. Nat Rev Neurosci. 2013 Jan.

Abstract

The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. Na(V)1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that Na(V)1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant Na(V)1.7 that causes pain.

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