Comment
doi: 10.1095/biolreprod.111.096461.
Print 2012 Jan.
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development
Affiliations
- PMID: 21957192
- PMCID: PMC3313660
- DOI: 10.1095/biolreprod.111.096461
Item in Clipboard
Comment
Gone without the WNT: a requirement for WNT5A in germ cell migration and testis development
Biol Reprod.
.
Abstract
The article by Chawengsaksophak et al. in this issue of Biology of Reproduction identifies the WNT5A signaling molecule as an important component that guides PGCs to their destination.
Figures
WNT5A controls several steps (red arrows) in gonadal development. Initially, WNT5A is required for the PGCs (yellow) migration into bipotential gonad. Upon sex determination, WNT5A controls proliferation of the somatic component of the testis and testicular descent. An unusual WNT5A expression pattern in the interstitial compartment of the testis is shown.
Comment on
-
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice.Biol Reprod. 2012 Jan 10;86(1):1-12. doi: 10.1095/biolreprod.111.095232. Print 2012 Jan. Biol Reprod. 2012. PMID: 21900680
Similar articles
-
Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice.Biol Reprod. 2012 Jan 10;86(1):1-12. doi: 10.1095/biolreprod.111.095232. Print 2012 Jan. Biol Reprod. 2012. PMID: 21900680
-
Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.Dev Biol. 2015 Feb 1;398(1):80-96. doi: 10.1016/j.ydbio.2014.11.015. Epub 2014 Dec 5. Dev Biol. 2015. PMID: 25482987
-
Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases.Dev Dyn. 2010 Jan;239(1):1-15. doi: 10.1002/dvdy.21991. Dev Dyn. 2010. PMID: 19530173 Review.
-
Up-regulation of Wnt5a gene expression in the nitrofen-induced hypoplastic lung.J Pediatr Surg. 2009 Dec;44(12):2302-6. doi: 10.1016/j.jpedsurg.2009.07.069. J Pediatr Surg. 2009. PMID: 20006014
-
Wnt-5A/B Signaling in Hematopoiesis throughout Life.Cells. 2020 Jul 29;9(8):1801. doi: 10.3390/cells9081801. Cells. 2020. PMID: 32751131 Free PMC article. Review.
Cited by
-
Wnt/β-catenin signaling pathway activation is required for proliferation of chicken primordial germ cells in vitro.Sci Rep. 2016 Sep 30;6:34510. doi: 10.1038/srep34510. Sci Rep. 2016. PMID: 27687983 Free PMC article.
-
16p11.2 transcription factor MAZ is a dosage-sensitive regulator of genitourinary development.Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1849-E1858. doi: 10.1073/pnas.1716092115. Epub 2018 Feb 5. Proc Natl Acad Sci U S A. 2018. PMID: 29432158 Free PMC article.
-
Yoga and its effect on sperm genomic integrity, gene expression, telomere length and perceived quality of life in early pregnancy loss.Sci Rep. 2024 May 22;14(1):11711. doi: 10.1038/s41598-024-62380-w. Sci Rep. 2024. PMID: 38777848 Free PMC article.
References
-
- Wilhelm D, Palmer S, Koopman P. Sex determination and gonadal development in mammals. Physiol Rev 2007; 87: 1 28 - PubMed
-
- Jakob S, Lovell-Badge R. Sex determination and the control of Sox9 expression in mammals. FEBS J 2011; 278: 1002 1009 - PubMed
-
- Chawengsaksophak K, Svingen T, Ng ET, Epp T, Spiller CM, Clark C, Cooper H, Koopman P. Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod 2012; 86: 4, 1 12 Published online ahead of print 7 September 2011; doi: 10.1095/biolreprod.111.095232 - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
