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Review
. 2009 Sep;29(9):1006-17.
doi: 10.1111/j.1468-2982.2009.01940.x.

Migraine and genetic and acquired vasculopathies

A H Stam  1 , J Haan, A M J M van den Maagdenberg, M D Ferrari, G M Terwindt
Affiliations
Review

Migraine and genetic and acquired vasculopathies

A H Stam et al. Cephalalgia. 2009 Sep.

Abstract

It is remarkable that migraine is a prominent part of the phenotype of several genetic vasculopathies, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), retinal vasculopathy with cerebral leukodystrophy (RVCL) and hereditary infantile hemiparessis, retinal arteriolar tortuosity and leukoencephalopahty (HIHRATL). The mechanisms by which these genetic vasculopathies give rise to migraine are still unclear. Common genetic susceptibility, increased susceptibility to cortical spreading depression (CSD) and vascular endothelial dysfunction are among the possible explanations. The relation between migraine and acquired vasculopathies such as ischaemic stroke and coronary heart disease has long been established, further supporting a role of the (cerebral) blood vessels in migraine. This review focuses on genetic and acquired vasculopathies associated with migraine. We speculate how genetic and acquired vascular mechanisms might be involved in migraine.

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