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Review
. 2008 Aug;106(4):1493-502.
doi: 10.1111/j.1471-4159.2008.05486.x. Epub 2008 May 15.

The Yin and Yang of YY1 in the nervous system

Ye He  1 , Patrizia Casaccia-Bonnefil
Affiliations
Review

The Yin and Yang of YY1 in the nervous system

Ye He et al. J Neurochem. 2008 Aug.

Abstract

The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species. However, its role varies in diverse cell types and includes proliferation, differentiation, and apoptosis. This review will focus on the function of YY1 in the nervous system including its role in neural development, neuronal function, developmental myelination, and neurological disease. The multiple functions of YY1 in distinct cell types are reviewed and the possible mechanisms underlying the cell specificity for these functions are discussed.

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Figures

Figure 1
Figure 1
Schematic diagram of human YY1 protein and its binding partners. The transcriptional activation and repression domains and the DNA binding domain are indicated. His, histidine-rich domain; GK, glycine-lysine-rich domain; PHR, PHO homology region. The protein/complex associated with YY1 are shown below each region of interaction. In parenthesis the aminoacid residues involved in binding are indicated. ND means not determined.
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