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. 2007 Dec;48(3):199-205.
doi: 10.1016/j.jdermsci.2007.07.003. Epub 2007 Aug 24.

A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita

Haihui Liao  1 , Jane M Sayers, Neil J Wilson, Alan D Irvine, Jemima E Mellerio, Eulalia Baselga, Susan J Bayliss, Vera Uliana, Michele Fimiani, E Birgitte Lane, W H Irwin McLean, Sancy A Leachman, Frances J D Smith
Affiliations

A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita

Haihui Liao et al. J Dermatol Sci. 2007 Dec.

Abstract

Background: Pachyonychia congenita (PC) is a rare autosomal dominant keratin disorder, subdivided into two major variants, PC-1 and PC-2. Predominant characteristics include hypertrophic nail dystrophy, focal palmoplantar keratoderma and oral leukokeratosis. Multiple steatocystomas that develop during puberty are a useful feature distinguishing PC-2 from PC-1. At the molecular level it has been shown that mutations in keratin K6a or K16 cause PC-1 whereas those in K6b or K17 lead to PC-2.

Objective: To identify mutations in 22 families presenting with clinical symptoms of either PC-1/focal non-epidermolytic palmoplantar keratoderma (FNEPPK) or PC-2.

Methods: Mutation analysis was performed on genomic DNA from PC patients by direct sequencing.

Results: Here, we report four new missense and five known mutations in K6a; one new deletion and three previously identified missense mutations in K16; plus one known mutation in K17.

Conclusion: With one exception, all these heterozygous mutations are within the highly conserved helix boundary motif regions at either end of the keratin rod domain. In one sporadic case, a unique mutation in K16 resulting in deletion of 24bp was found within the central rod domain, in a child with a phenotype predominantly consisting of focal plantar keratoderma. The identification of mutations in cases of PC is prerequisite for future development of gene-specific and/or mutation-specific therapies.

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