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Randomized Controlled Trial
. 2005 Oct;193(4):1292-301.
doi: 10.1016/j.ajog.2005.05.016.

Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trial

Janette Khoury  1 , Tore Henriksen, Bjørn Christophersen, Serena Tonstad
Affiliations
Randomized Controlled Trial

Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trial

Janette Khoury et al. Am J Obstet Gynecol. 2005 Oct.

Abstract

Objective: We assessed the effect of a cholesterol-lowering diet on maternal, cord, and neonatal plasma lipids and pregnancy outcome.

Study design: Nonsmoking white women with singleton pregnancies (n = 290), aged 21 to 38 years, and with no previous pregnancy-related complications, were randomized to either continue their usual diet or to adopt a diet that promoted fish, low-fat meats and dairy products, oils, whole grains, fruits, vegetables, and legumes from gestational week 17 to 20 to birth.

Results: Maternal total and low-density lipoprotein cholesterol levels were lowered in the intervention compared with the control group (P < .01). Lipid levels in cord blood and in neonates born to mothers in the intervention versus the control groups did not differ. In the intention-to-treat cohort 1 (0.7%) of 141 women in the intervention group versus 11 (7.4%) of 149 women in the control group delivered before 37 weeks (RR 0.10; 95% CI 0.01-0.77). The incidence of other pregnancy complications and birth weight was similar in both groups.

Conclusion: A cholesterol-lowering diet may modify maternal lipid levels but not cord and neonatal lipids. The marked observed effect of this diet on the reduction of preterm delivery in low-risk pregnancies should encourage future larger studies to clarify the role of such a diet in the prevention of preterm birth.

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Comment in

  • Déjá vu or did we really make progress?
    Basaran A, Deren O. Basaran A, et al. Am J Obstet Gynecol. 2006 Dec;195(6):e1; author reply e2. doi: 10.1016/j.ajog.2006.05.026. Epub 2006 Jul 5. Am J Obstet Gynecol. 2006. PMID: 16824457 No abstract available.

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