Review
doi: 10.1038/ncb1104-1034.
The many faces of filamin: a versatile molecular scaffold for cell motility and signalling
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- PMID: 15516996
- DOI: 10.1038/ncb1104-1034
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Review
The many faces of filamin: a versatile molecular scaffold for cell motility and signalling
Nat Cell Biol.
2004 Nov.
Abstract
Filamins were discovered as the first family of non-muscle actin-binding protein. They are lage cytoplasmic proteins that cross-link cortical actin into a dynamic three-dimensional structure. Filamins have also been reported to interact with a large number of cellular proteins of great functional diversity, suggesting that they are unusually versatile signalling scaffolds. More recently, genetic mutations in filamin A and B have been reported to cause a wide range of human diseases, suggesting that different diseases highlight distinct filamin interactions.
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