Frontotemporal dementia: a randomised, controlled trial with trazodone
- PMID: 15178953
- DOI: 10.1159/000077171
Frontotemporal dementia: a randomised, controlled trial with trazodone
Abstract
Behavioural troubles due to frontotemporal dementia (FTD) are difficult to treat. The serotonergic system is associated with frontal lobes, the degeneration of which contributes to FTD. Trazodone increases the extracellular 5-HT levels in the frontal cortex. In a randomised, double-blind, placebo-controlled cross-over study, we investigated the effect of trazodone. There was a significant decrease in the Neuropsychiatry Inventory (NPI) total score with trazodone (p = 0.028) in the 26 evaluable patients. A decrease of more than 50% in the NPI score was observed in 10 patients with trazodone. This improvement was mainly based on the improvement of 4 items of the scale (irritability, agitation, depressive symptoms and eating disorders). The Mini-Mental State Examination was not modified and trazodone was well tolerated. Results of this first placebo-controlled trial suggest that trazodone is an effective treatment for the behavioural symptoms of FTD.
Copyright 2004 S. Karger AG, Basel
Similar articles
-
Trazodone for agitation in dementia.Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004990. doi: 10.1002/14651858.CD004990. Cochrane Database Syst Rev. 2004. PMID: 15495135 Review.
-
Antidepressants for agitation and psychosis in dementia.Cochrane Database Syst Rev. 2011 Feb 16;(2):CD008191. doi: 10.1002/14651858.CD008191.pub2. Cochrane Database Syst Rev. 2011. PMID: 21328305 Review.
-
A comparative, randomised, double-blind study of trazodone prolonged-release and paroxetine in the treatment of patients with major depressive disorder.Curr Med Res Opin. 2005 Aug;21(8):1139-46. doi: 10.1185/030079905X53243. Curr Med Res Opin. 2005. PMID: 16083521 Clinical Trial.
-
Trazodone as an Alternative Treatment for Neuroleptic-Associated Akathisia: A Placebo-Controlled, Double-Blind, Clinical Trial.J Clin Psychopharmacol. 2020 Nov/Dec;40(6):611-614. doi: 10.1097/JCP.0000000000001286. J Clin Psychopharmacol. 2020. PMID: 33044356 Clinical Trial.
-
Trazodone, a double blind trial for treatment of erectile dysfunction.Int J Impot Res. 1997 Sep;9(3):163-5. doi: 10.1038/sj.ijir.3900272. Int J Impot Res. 1997. PMID: 9315494 Clinical Trial.
Cited by
-
Diagnosis and management of behavioral issues in frontotemporal dementia.Curr Neurol Neurosci Rep. 2012 Oct;12(5):528-36. doi: 10.1007/s11910-012-0302-7. Curr Neurol Neurosci Rep. 2012. PMID: 22847063 Free PMC article. Review.
-
Treatment options for tauopathies.Curr Treat Options Neurol. 2012 Apr;14(2):126-36. doi: 10.1007/s11940-012-0168-7. Curr Treat Options Neurol. 2012. PMID: 22307450
-
Therapy and clinical trials in frontotemporal dementia: past, present, and future.J Neurochem. 2016 Aug;138 Suppl 1(Suppl 1):211-21. doi: 10.1111/jnc.13640. Epub 2016 Jun 15. J Neurochem. 2016. PMID: 27306957 Free PMC article. Review.
-
Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials.Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):123-32. doi: 10.1177/1533317513507375. Epub 2013 Oct 27. Am J Alzheimers Dis Other Demen. 2014. PMID: 24164931 Free PMC article. Review.
-
Alternatives to atypical antipsychotics for the management of dementia-related agitation.Drugs Aging. 2008;25(5):381-98. doi: 10.2165/00002512-200825050-00003. Drugs Aging. 2008. PMID: 18447403 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
