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Multicenter Study
. 2004 Jan;124(1):114-7.
doi: 10.1046/j.1365-2141.2003.04732.x.

Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti  1 , Gianluca Vergine, Turi Lombardo, Maria Domenica Cappellini, Paolo Cianciulli, Aurelio Maggio, Disma Renda, Maria Eliana Lai, Antonella Mandas, Gianluca Forni, Antonio Piga, Maria Grazia Bisconte
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Free article
Multicenter Study

Hepatocellular carcinoma in the thalassaemia syndromes

Caterina Borgna-Pignatti et al. Br J Haematol. 2004 Jan.
Free article

Abstract

Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload. Therefore, patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour. We collected data on patients attending Italian centres for the treatment of thalassaemia. Twenty-two cases of HCC were identified; 15 were male. At diagnosis, the mean age was 45 +/- 11 years and the mean serum ferritin was 1764 +/- 1448 microg/l. Eighty-six percent had been infected by hepatitis C virus. Nineteen of 22 cases were diagnosed after 1993, suggesting that this problem is becoming more frequent with the aging population of thalassaemia patients.

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