An essential role for Scurfin in CD4+CD25+ T regulatory cells
- PMID: 12612581
- DOI: 10.1038/ni909
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Abstract
The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and encoded by Foxp3) causes a rapidly fatal lymphoproliferative disease, similar to that seen in mice lacking cytolytic T lymphocyte-associated antigen 4 (CTLA-4). Here we show that Foxp3 is highly expressed by T(R) cells and is associated with T(R) cell activity and phenotype. Scurfin-deficient mice lack T(R) cells, whereas mice that overexpress Foxp3 possess more T(R) cells. In Foxp3-overexpressing mice, both CD4+CD25- and CD4-CD8+ T cells show suppressive activity and CD4+CD25- cells express glucocorticoid-induced tumor-necrosis factor receptor-related (GITR) protein. The forced expression of Foxp3 also delays disease in CTLA-4-/- mice, indicating that the Scurfin and CTLA-4 pathways may intersect and providing further insight into the T(R) cell lineage.
Comment in
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Twenty-first century Foxp3.Nat Immunol. 2003 Apr;4(4):304-6. doi: 10.1038/ni0403-304. Nat Immunol. 2003. PMID: 12660726 No abstract available.
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