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. 2002 Nov;17(6):1271-7.
doi: 10.1002/mds.10271.

Phenomenology of "Lubag" or X-linked dystonia-parkinsonism

Virgilio Gerald H Evidente  1 , Joel Advincula, Raymund Esteban, Paul Pasco, Jhoe Anthony Alfon, Filipinas F Natividad, Joven Cuanang, Amado San Luis, Katrina Gwinn-Hardy, John Hardy, Dena Hernandez, Andrew Singleton
Affiliations

Phenomenology of "Lubag" or X-linked dystonia-parkinsonism

Virgilio Gerald H Evidente et al. Mov Disord. 2002 Nov.

Abstract

X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay. We present cinematographic material of 11 cases of Lubag carrying the XDP haplotypes who manifest with a wide spectrum of movement disorders, including dystonia, tremor, parkinsonism, myoclonus, chorea, and myorhythmia. Because of overlapping features, Lubag patients are commonly misdiagnosed as idiopathic dystonia, essential tremor, Parkinson's disease, or Parkinson's-plus syndromes. Thus, it is imperative to elicit an exhaustive family history in any Filipino male adult who presents with a movement disorder.

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