Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding
- PMID: 11331068
- DOI: 10.1016/s0006-2952(01)00633-5
Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding
Abstract
The standard model of signal transduction from G-protein-coupled receptors (GPCRs) involves guanine nucleotide cycling by a heterotrimeric G-protein assembly composed of Galpha, Gbeta, and Ggamma subunits. The WD-repeat beta-propeller protein Gbeta and the alpha-helical, isoprenylated polypeptide Ggamma are considered obligate dimerization partners; moreover, conventional Gbetagamma heterodimers are considered essential to the functional coupling of Galpha subunits to receptors. However, our recent discovery of a Gbeta5 binding site (the Ggamma-like or "GGL" domain) within several regulators of G-protein signaling (RGS) proteins revealed the potential for functional GPCR/Galpha coupling in the absence of a conventional Ggamma subunit. In addition, we posit that the interaction between Gbeta5 isoforms and the GGL domains of RGS proteins represents a general mode of binding between beta-propeller proteins and their partners, extending beyond the realm of G-protein-linked signal transduction.
Similar articles
-
Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function.Curr Biol. 2001 Feb 20;11(4):222-31. doi: 10.1016/s0960-9822(01)00071-9. Curr Biol. 2001. PMID: 11250150
-
Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.Proc Natl Acad Sci U S A. 1999 May 25;96(11):6489-94. doi: 10.1073/pnas.96.11.6489. Proc Natl Acad Sci U S A. 1999. PMID: 10339615 Free PMC article.
-
Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells.J Biol Chem. 2000 Aug 11;275(32):24872-80. doi: 10.1074/jbc.M001535200. J Biol Chem. 2000. PMID: 10840031
-
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.Int J Biol Sci. 2005;1(2):51-66. doi: 10.7150/ijbs.1.51. Epub 2005 Apr 1. Int J Biol Sci. 2005. PMID: 15951850 Free PMC article. Review.
-
Use of RGS-insensitive Galpha subunits to study endogenous RGS protein action on G-protein modulation of N-type calcium channels in sympathetic neurons.Methods Enzymol. 2004;389:170-89. doi: 10.1016/S0076-6879(04)89011-6. Methods Enzymol. 2004. PMID: 15313566 Review.
Cited by
-
RACK1, A multifaceted scaffolding protein: Structure and function.Cell Commun Signal. 2011 Oct 6;9:22. doi: 10.1186/1478-811X-9-22. Cell Commun Signal. 2011. PMID: 21978545 Free PMC article.
-
RACK1 is involved in endothelial barrier regulation via its two novel interacting partners.Cell Commun Signal. 2013 Jan 11;11(1):2. doi: 10.1186/1478-811X-11-2. Cell Commun Signal. 2013. PMID: 23305203 Free PMC article.
-
G protein trafficking.Subcell Biochem. 2012;63:193-223. doi: 10.1007/978-94-007-4765-4_11. Subcell Biochem. 2012. PMID: 23161140 Free PMC article. Review.
-
OsRap2.6 transcription factor contributes to rice innate immunity through its interaction with Receptor for Activated Kinase-C 1 (RACK1).Rice (N Y). 2012 Dec 11;5(1):35. doi: 10.1186/1939-8433-5-35. Rice (N Y). 2012. PMID: 24280008 Free PMC article.
-
R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine.Neuropsychopharmacology. 2010 Mar;35(4):1040-50. doi: 10.1038/npp.2009.212. Epub 2009 Dec 30. Neuropsychopharmacology. 2010. PMID: 20043004 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
