{"id":14180,"date":"2024-11-14T09:52:45","date_gmt":"2024-11-14T14:52:45","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=14180"},"modified":"2024-11-14T09:52:45","modified_gmt":"2024-11-14T14:52:45","slug":"refseq-release-227","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/","title":{"rendered":"RefSeq Release 227 is Available!"},"content":{"rendered":"<p>Check out RefSeq release 227, now available <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">online<\/a>\u00a0and from the\u00a0<a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/refseq\/release\/\">FTP<\/a>\u00a0site. You can access RefSeq data through\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241113\">NCBI Datasets<\/a>. The release is provided in several directories as a complete dataset and also as divided by logical groupings.<\/p>\n<h5>What\u2019s included in this release?<\/h5>\n<p>As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">497,549,107 records, including <\/span><\/li>\n<li><span style=\"font-size: 17px;\">377,783,847 proteins<\/span><\/li>\n<li><span style=\"font-size: 17px;\">66,987,567 RNAs<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Sequences from 159,324 organisms\u00a0<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<h5><b>Lineage updates for prokaryotes<\/b><\/h5>\n<p><a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/10\/02\/ncbi-taxonomy-updates-prokaryotes\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">Lineage updates<\/a> affecting all prokaryotes are in progress. This affects the lineage shown in the ORGANISM block of the flatfile records.<\/p>\n<h5><b>Genome contamination reports<\/b><\/h5>\n<p>Comprehensive <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/09\/24\/public-reports-fcs-tool-results\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">reports of contamination<\/a> found in prokaryote and eukaryote genomes are now available for both GenBank and RefSeq genomes. This information can be used to better understand possible issues that may affect your studies, and to select against contaminated assemblies or remove contaminant sequences.<\/p>\n<h5><b>New MANE release<\/b><\/h5>\n<p>The <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/10\/28\/mane-v1-4-mane-select-non-coding-genes\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">MANE v1.4 dataset<\/a> is now available, including the addition of 50 non-coding genes associated with human diseases.<\/p>\n<h5><b>New eukaryotic genome annotations<\/b><\/h5>\n<p>This release contains new or updated annotations generated by NCBI&#8217;s eukaryotic genome annotation pipeline for 41 species, including:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">Bennett&#8217;s brown lemur, based on new assembly OSU_ERuf_1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_041146395.1\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">GCF_041146395.1-RS_2024_10<\/a>) <em>(pictured)<\/em><\/span><\/li>\n<li><span style=\"font-size: 17px;\">Sumatran serow, based on new assembly serow.2 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_032405125.1\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">GCF_032405125.1-RS_2024_10<\/a>)<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Spotted gar, based on new assembly fLepOcu1.hap2x (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_040954835.1\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">GCF_040954835.1-RS_2024_09<\/a>)<\/span><\/li>\n<li><span style=\"font-size: 17px;\">Pipe-vine swallowtail, based on new assembly ilBatPhil1.0.hap1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_028537555.1\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">GCF_028537555.1-RS_2024_09<\/a>)<\/span><\/li>\n<li><span style=\"font-size: 17px;\">String bean, based on updated assembly P. vulgaris v2.0 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/datasets\/genome\/GCF_000499845.2\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241114\">GCF_000499845.2-RS_2024_09<\/a>)<\/span><\/li>\n<\/ul>\n<h4>Stay up to date<\/h4>\n<p>RefSeq is part of the\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/comparative-genomics-resource\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=refseq-release-227-20241113\">NIH Comparative Genomics Resource (CGR)<\/a>.\u00a0<span data-contrast=\"none\">CGR facilitates reliable comparative genomics analyses\u202ffor all eukaryotic organisms through an NCBI Toolkit and community collaboration.\u00a0<\/span><span class=\"TextRun Highlight SCXW148001688 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW148001688 BCX8\">Follow us on social\u202f<\/span><\/span><a class=\"Hyperlink SCXW148001688 BCX8\" href=\"https:\/\/twitter.com\/ncbi\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"TextRun Highlight SCXW148001688 BCX8\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW148001688 BCX8\" data-ccp-charstyle=\"Hyperlink\">@NCBI<\/span><\/span><\/a>\u00a0and\u00a0<a class=\"external-link\" href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_50%22\" rel=\"nofollow\">join our mailing list<\/a>\u00a0to keep up to date with RefSeq and other CGR news.<\/p>\n<h4>Questions?<\/h4>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please\u00a0<a href=\"https:\/\/support.nlm.nih.gov\/support\/create-case\/\">reach out<\/a>\u00a0to us!<\/span><span data-contrast=\"auto\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Check out RefSeq release 227, now available online\u00a0and from the\u00a0FTP\u00a0site. You can access RefSeq data through\u00a0NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What\u2019s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: &hellip; <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">RefSeq Release 227 is Available!<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":14186,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"RefSeq Release 227 is Available!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060768,693060858,1201719,782519,693060836,34457,3995510,27739816],"table_tags":[],"class_list":["post-14180","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-comparative-genomics-resource-cgr","tag-foreign-contamination-screen-fcs-tool","tag-genbank","tag-mane","tag-ncbi-datasets","tag-taxonomy","tag-prokaryotes","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RefSeq Release 227 is Available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RefSeq Release 227 is Available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Check out RefSeq release 227, now available online\u00a0and from the\u00a0FTP\u00a0site. You can access RefSeq data through\u00a0NCBI Datasets. The release is provided in several directories as a complete dataset and also as divided by logical groupings. What\u2019s included in this release? As of November 4, 2024, this full release incorporates genomic, transcript, and protein data containing: &hellip; Continue reading RefSeq Release 227 is Available! &rarr;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-14T14:52:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/iStock-1789702766-e1731518454958.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1100\" \/>\n\t<meta property=\"og:image:height\" content=\"694\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"RefSeq Release 227 is Available!\",\"datePublished\":\"2024-11-14T14:52:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\"},\"wordCount\":304,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/11\/iStock-1789702766-e1731518454958.jpg?fit=1100%2C694&ssl=1\",\"keywords\":[\"Comparative Genomics Resource (CGR)\",\"Foreign Contamination Screen (FCS) Tool\",\"GenBank\",\"Matched Annotation from NCBI and EMBL-EBI (MANE)\",\"NCBI Datasets\",\"NCBI Taxonomy\",\"Prokaryotes\",\"RefSeq\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/11\/14\/refseq-release-227\/\",\"name\":\"RefSeq Release 227 is Available! 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