{"id":14137,"date":"2024-10-30T10:37:52","date_gmt":"2024-10-30T14:37:52","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=14137"},"modified":"2024-10-31T10:46:01","modified_gmt":"2024-10-31T14:46:01","slug":"ortholog-data-refseq-arthropods","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/10\/30\/ortholog-data-refseq-arthropods\/","title":{"rendered":"Expansion of Ortholog Data for RefSeq Arthropods"},"content":{"rendered":"

250K+ new <\/span><\/i>Hymenoptera orthologs added<\/span><\/i>\u00a0<\/span><\/h3>\n

NCBI is excited to announce the expansion of ortholog data for RefSeq<\/a> arthropods. This update <\/span>expands the breadth of arthropod orthology information<\/span>, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new possibilities for research. <\/span>Check out our <\/span>previous blog<\/span><\/a> to learn how to access the orthologs using NCBI Datasets<\/a>.<\/span>\u00a0<\/span><\/p>\n

What\u2019s new?<\/span><\/b>\u00a0<\/span><\/h5>\n

New species<\/span><\/b>: Non-insect arthropod species are now included to identify one-to-one orthologs with <\/span>Drosophila <\/span><\/i>(fruit fly), enriching the existing dataset with genes from over 45 additional species including spiders and ticks.<\/span>\u00a0<\/span><\/p>\n

Expanded Ortholog Data for Hymenoptera<\/em><\/span><\/b>: We have further enriched the insect dataset with over 250,000 one-to-one orthologs found within the order Hymenoptera<\/em> (ants, wasps, and bees), identified by comparison to the <\/span>Apis mellifera <\/span><\/i>(honeybee) gene set, supplementing the more broadly conserved orthologs shared with <\/span>Drosophila.<\/span><\/i>\u00a0 <\/span>\u00a0<\/span><\/p>\n

Example:<\/span><\/b>\u00a0<\/span><\/p>\n

The <\/span>apisimin<\/span><\/a> genes of honeybees encode a peptide component of royal jelly, which fulfills the nutritional needs of the queen bee. Because these genes are specific to honeybees, they were absent from ortholog datasets that used fruit flies as a reference. However, with the recent expansion of ortholog data incorporating honeybees as an additional reference, five apisimin genes in different <\/span>Apis <\/span><\/i>species have now been identified as orthologs. This expansion allows you to study thousands of genes that are unique to order <\/span>Hymenoptera<\/span><\/i>.<\/span> \u202f<\/span>\u00a0<\/span>\u00a0<\/span><\/p>\n

\"\"<\/p>\n

Figure 1:<\/span><\/i><\/b> NCBI’s Multiple Sequence Alignment (MSA) Viewer displaying honeybee apisimin ortholog proteins generated using NCBI COBALT. Amino acid residues conserved across the five orthologs are depicted in gray while unconserved residues are highlighted in red. <\/span><\/i>\u00a0<\/span><\/p>\n

Stay up to date\u202f\u202f<\/span><\/b>\u00a0<\/span><\/h5>\n

NCBI Orthologs and NCBI Datasets are part of the\u202f<\/span>NIH Comparative Genomics Resource (CGR)<\/span><\/a>. CGR facilitates reliable comparative genomics analyses\u202ffor all eukaryotic organisms through an NCBI Toolkit and community collaboration.\u202f<\/span>\u00a0<\/span><\/p>\n

Join our mailing list<\/span><\/a>\u202fto keep up to date with NCBI Datasets and other CGR news.\u202f<\/span>\u00a0<\/span><\/p>\n

Questions?<\/span><\/b>\u00a0<\/span><\/h5>\n

you have questions or would like to provide feedback, please reach out to us at <\/span>info@ncbi.nlm.nih.gov<\/span><\/a>.\u202f<\/span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

250K+ new Hymenoptera orthologs added\u00a0 NCBI is excited to announce the expansion of ortholog data for RefSeq arthropods. This update expands the breadth of arthropod orthology information, offering new insights into evolutionary biology, gene function, and shared pathways. Whether you’re studying insect genetics, developmental biology, or comparative genomics, the expanded ortholog data opens up new … Continue reading Expansion of Ortholog Data for RefSeq Arthropods<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":14147,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Expansion of Ortholog Data for RefSeq Arthropods","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060768,693060836,27739816],"table_tags":[],"class_list":["post-14137","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-comparative-genomics-resource-cgr","tag-ncbi-datasets","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"\nExpansion of Ortholog Data for RefSeq Arthropods - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/10\/30\/ortholog-data-refseq-arthropods\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Expansion of Ortholog Data for RefSeq Arthropods - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"250K+ new Hymenoptera orthologs added\u00a0 NCBI is excited to announce the expansion of ortholog data for RefSeq arthropods. This update expands the breadth of arthropod orthology information, offering new insights into evolutionary biology, gene function, and shared pathways. 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