{"id":13763,"date":"2024-08-22T10:24:37","date_gmt":"2024-08-22T14:24:37","guid":{"rendered":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/?p=13763"},"modified":"2024-08-26T10:05:20","modified_gmt":"2024-08-26T14:05:20","slug":"hmm-release-16-now-available","status":"publish","type":"post","link":"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/","title":{"rendered":"NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!"},"content":{"rendered":"<p><a href=\"https:\/\/ftp.ncbi.nlm.nih.gov\/hmm\/16.0\/\">Download release 16.0<\/a> of the NCBI protein profile Hidden Markov models (HMMs) used by the\u00a0<a class=\"external-link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/annotation_prok\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-16-20240822\" target=\"_blank\" rel=\"nofollow noopener\">Prokaryotic Genome Annotation Pipeline (PGAP)<\/a>! Search this collection against your favorite prokaryotic proteins to identify their function using the\u00a0<a class=\"external-link\" href=\"http:\/\/eddylab.org\/software\/hmmer\/Userguide.pdf\" target=\"_blank\" rel=\"nofollow noopener\">HMMER sequence analysis package<\/a>.<\/p>\n<h5>What\u2019s New?<\/h5>\n<p>Release 16.0 contains:<\/p>\n<ul>\n<li><span style=\"font-size: 17px;\">17,078 HMMs maintained by NCBI<\/span><\/li>\n<li><span style=\"font-size: 17px;\">406 new HMMs since release 15.0<\/span><\/li>\n<li><span style=\"font-size: 17px;\">The GO terms between NCBI HMMs and the corresponding <a class=\"external-link\" href=\"https:\/\/www.ebi.ac.uk\/interpro\/\" target=\"_blank\" rel=\"nofollow noopener\">Interpro<\/a> entries were compared and evaluated over a substantial number of HMMs and updated (added: 307; deleted: 39; updated: 1,482).\u00a0<\/span><\/li>\n<\/ul>\n<p><!--more--><\/p>\n<p>You can search and view the details for these in the\u00a0<a class=\"external-link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/protfam?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-16-20240822\" target=\"_blank\" rel=\"nofollow noopener\">Protein Family Model<\/a>\u00a0collection, which also includes conserved domain architectures and BlastRules, and access all\u00a0<a class=\"external-link\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/refseq\/?utm_source=ncbi_insights&amp;utm_medium=referral&amp;utm_campaign=hmm-release-16-2024822\" target=\"_blank\" rel=\"nofollow noopener\">RefSeq<\/a>\u00a0proteins that these models name.<\/p>\n<h5>Stay up to date<\/h5>\n<p><span data-contrast=\"auto\">Follow us on social\u202f<\/span><a href=\"https:\/\/twitter.com\/ncbi\"><span data-contrast=\"auto\">@NCBI<\/span><\/a><span data-contrast=\"auto\">\u202fand\u202f<\/span><a href=\"https:\/\/public.govdelivery.com\/accounts\/USNLMOCPL\/subscriber\/new?topic_id=USNLMOCPL_52\"><span data-contrast=\"auto\">join our mailing list<\/span><\/a><span data-contrast=\"auto\">\u202fto keep up to date with\u202fHMM\u202fand other NCBI news.\u202f\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335559738&quot;:150,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<h5>We want to hear from you!<\/h5>\n<p><span data-contrast=\"auto\">If you have questions or would like to provide feedback, please reach out to us at <a href=\"mailto:info@ncbi.nlm.nih.gov\">info@ncbi.nlm.nih.gov<\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Download release 16.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the\u00a0Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the\u00a0HMMER sequence analysis package. What\u2019s New? Release 16.0 contains: 17,078 HMMs maintained by NCBI 406 new HMMs since release 15.0 The GO terms &hellip; <a href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":42204617,"featured_media":13765,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[2248],"tags":[693060700,15779425,693060702,27739816],"table_tags":[],"class_list":["post-13763","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whats-new","tag-hidden-markov-models-hmm","tag-pgap","tag-protein-family-model","tag-refseq"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>NCBI Hidden Markov Models (HMM) Release 16.0 Now Available! - NCBI Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NCBI Hidden Markov Models (HMM) Release 16.0 Now Available! - NCBI Insights\" \/>\n<meta property=\"og:description\" content=\"Download release 16.0 of the NCBI protein profile Hidden Markov models (HMMs) used by the\u00a0Prokaryotic Genome Annotation Pipeline (PGAP)! Search this collection against your favorite prokaryotic proteins to identify their function using the\u00a0HMMER sequence analysis package. What\u2019s New? Release 16.0 contains: 17,078 HMMs maintained by NCBI 406 new HMMs since release 15.0 The GO terms &hellip; Continue reading NCBI Hidden Markov Models (HMM) Release 16.0 Now Available! &rarr;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\" \/>\n<meta property=\"og:site_name\" content=\"NCBI Insights\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/ncbi.nlm\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-22T14:24:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-26T14:05:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/08\/HMM_Release-8-e1724266030383.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1100\" \/>\n\t<meta property=\"og:image:height\" content=\"575\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"NCBI Staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@NCBI\" \/>\n<meta name=\"twitter:site\" content=\"@NCBI\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"NCBI Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\"},\"author\":{\"name\":\"NCBI Staff\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#\/schema\/person\/4f41ea6a31cea38a9a1b1419c048e50b\"},\"headline\":\"NCBI Hidden Markov Models (HMM) Release 16.0 Now Available!\",\"datePublished\":\"2024-08-22T14:24:37+00:00\",\"dateModified\":\"2024-08-26T14:05:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\"},\"wordCount\":168,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#organization\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/08\/HMM_Release-8-e1724266030383.png?fit=1100%2C575&ssl=1\",\"keywords\":[\"Hidden Markov Models (HMM)\",\"NCBI Prokaryotic Genome Annotation Pipeline (PGAP)\",\"Protein Family Model\",\"RefSeq\"],\"articleSection\":[\"What's New\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\",\"url\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\",\"name\":\"NCBI Hidden Markov Models (HMM) Release 16.0 Now Available! - NCBI Insights\",\"isPartOf\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/08\/HMM_Release-8-e1724266030383.png?fit=1100%2C575&ssl=1\",\"datePublished\":\"2024-08-22T14:24:37+00:00\",\"dateModified\":\"2024-08-26T14:05:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/ncbiinsights.ncbi.nlm.nih.gov\/2024\/08\/22\/hmm-release-16-now-available\/#primaryimage\",\"url\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/08\/HMM_Release-8-e1724266030383.png?fit=1100%2C575&ssl=1\",\"contentUrl\":\"https:\/\/i0.wp.com\/ncbiinsights.ncbi.nlm.nih.gov\/wp-content\/uploads\/2024\/08\/HMM_Release-8-e1724266030383.png?fit=1100%2C575&ssl=1\",\"width\":1100,\"height\":575,\"caption\":\"Colorful squares stacked in the background with letters in them. 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Search this collection against your favorite prokaryotic proteins to identify their function using the\u00a0HMMER sequence analysis package. What\u2019s New? 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