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NEI Research News

Thanks to the work of NEI scientists and grantees, we’re constantly learning new information about the causes and treatment of vision disorders. Get the latest updates about their work — along with other news about NEI.

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Two boys smile at camera. The outer portion of the image is darkened, representing vision loss from glaucoma.

New genetic mutation behind childhood glaucoma identified

An international team led by Harvard Medical School scientists has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families.

New UC Irvine-led study shows repeated stress accelerates aging of the eye

Researchers say findings reveal potential glaucoma drugs targets.

3D map reveals DNA organization within human retina cells

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell’s nucleus.
Graph showing that odd ratio for advanced vision loss for African Americans is significantly higher than for non-hispanic whites.

Black patients found six times more likely to have advanced vision loss after glaucoma diagnosis than white patients

Black patients have a dramatically higher risk of advanced vision loss after a new diagnosis of primary open angle glaucoma (POAG) when compared to white patients, according to a new study from New York Eye and Ear Infirmary of Mount Sinai (NYEE).
Kathryn Bollinger Sylvia Smith

Protein protects brain cells most impacted by glaucoma

Protein sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of retinal ganglion cells (RGCs) in culture.
A diagram of the eye with a green arrow showing how fluid normally passes through the space between the iris and the cornea and drains out of the eye back into the bloodstream.

A new treatment for glaucoma?

A Northwestern Medicine study in mice has identified new treatment targets for glaucoma, including preventing a severe pediatric form of glaucoma, as well as uncovering a possible new class of therapy for the most common form of glaucoma in adults.
AGI identity mark

Learning how transplanted neurons fit in

As scientists move closer to testing regenerative therapies for eye disease, techniques are needed to monitor transplanted cells as they integrate with host tissues.
Female shown from overhead standing with her eye open receiving OCT scan.

NEI-funded technology promises to broaden access to retinal scanning

A National Eye Institute-funded project at Duke University has yielded a fully automated optical coherence tomography (OCT) device that does not require a trained operator and promises to broaden access to retinal imaging technology.
Schematic of photoreceptors and bipolar cells in the retina.

Scientists discover gene therapy provides neuroprotection to prevent glaucoma vision loss

A form of gene therapy protects optic nerve cells and preserves vision in mouse models of glaucoma, according to research supported by NIH’s National Eye Institute. The findings suggest a way forward for developing neuroprotective therapies for glaucoma.
A mug of coffee

High caffeine consumption may be associated with increased risk of blinding eye disease

Consuming large amounts of daily caffeine may increase the risk of glaucoma more than three-fold for those with a genetic predisposition to higher eye pressure according to an international, multi-center study.

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