dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs2279744
Current Build 156
Released September 21, 2022
- Organism
- Homo sapiens
- Position
-
chr12:68808800 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- T>A / T>G
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
G=0.315365 (83474/264690, TOPMED)G=0.306509 (42861/139836, GnomAD)G=0.31513 (24796/78684, PAGE_STUDY) (+ 16 more)
- Clinical Significance
- Reported in ClinVar
- Gene : Consequence
- MDM2 : Intron Variant
- Publications
- 149 citations
- Genomic View
- See rs on genome
ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20231103111315
| Population | Group | Sample Size | Ref Allele | Alt Allele | Ref HMOZ | Alt HMOZ | HTRZ | HWEP |
|---|---|---|---|---|---|---|---|---|
| Total | Global | 41512 | T=0.68147 | A=0.00000, G=0.31853 | 0.490991 | 0.128059 | 0.38095 | 32 |
| European | Sub | 28262 | T=0.68014 | A=0.00000, G=0.31986 | 0.475621 | 0.115349 | 0.40903 | 27 |
| African | Sub | 4982 | T=0.9291 | A=0.0000, G=0.0709 | 0.86953 | 0.01124 | 0.119229 | 12 |
| African Others | Sub | 174 | T=0.966 | A=0.000, G=0.034 | 0.942529 | 0.011494 | 0.045977 | 5 |
| African American | Sub | 4808 | T=0.9278 | A=0.0000, G=0.0722 | 0.866889 | 0.011231 | 0.12188 | 11 |
| Asian | Sub | 388 | T=0.492 | A=0.000, G=0.508 | 0.237113 | 0.252577 | 0.510309 | 0 |
| East Asian | Sub | 338 | T=0.470 | A=0.000, G=0.530 | 0.213018 | 0.272189 | 0.514793 | 0 |
| Other Asian | Sub | 50 | T=0.64 | A=0.00, G=0.36 | 0.4 | 0.12 | 0.48 | 0 |
| Latin American 1 | Sub | 488 | T=0.717 | A=0.000, G=0.283 | 0.516393 | 0.081967 | 0.401639 | 0 |
| Latin American 2 | Sub | 4210 | T=0.4264 | A=0.0000, G=0.5736 | 0.191924 | 0.339192 | 0.468884 | 2 |
| South Asian | Sub | 96 | T=0.57 | A=0.00, G=0.43 | 0.458333 | 0.3125 | 0.229167 | 8 |
| Other | Sub | 3086 | T=0.6633 | A=0.0000, G=0.3367 | 0.45755 | 0.130914 | 0.411536 | 6 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| TopMed | Global | Study-wide | 264690 | T=0.684635 | G=0.315365 |
| gnomAD - Genomes | Global | Study-wide | 139836 | T=0.693491 | G=0.306509 |
| gnomAD - Genomes | European | Sub | 75718 | T=0.63700 | G=0.36300 |
| gnomAD - Genomes | African | Sub | 41918 | T=0.89155 | G=0.10845 |
| gnomAD - Genomes | American | Sub | 13612 | T=0.50786 | G=0.49214 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 3320 | T=0.4886 | G=0.5114 |
| gnomAD - Genomes | East Asian | Sub | 3116 | T=0.4669 | G=0.5331 |
| gnomAD - Genomes | Other | Sub | 2152 | T=0.6417 | G=0.3583 |
| The PAGE Study | Global | Study-wide | 78684 | T=0.68487 | G=0.31513 |
| The PAGE Study | AfricanAmerican | Sub | 32512 | T=0.88558 | G=0.11442 |
| The PAGE Study | Mexican | Sub | 10808 | T=0.41192 | G=0.58808 |
| The PAGE Study | Asian | Sub | 8312 | T=0.4583 | G=0.5417 |
| The PAGE Study | PuertoRican | Sub | 7916 | T=0.6392 | G=0.3608 |
| The PAGE Study | NativeHawaiian | Sub | 4534 | T=0.6489 | G=0.3511 |
| The PAGE Study | Cuban | Sub | 4230 | T=0.6508 | G=0.3492 |
| The PAGE Study | Dominican | Sub | 3828 | T=0.7424 | G=0.2576 |
| The PAGE Study | CentralAmerican | Sub | 2450 | T=0.4910 | G=0.5090 |
| The PAGE Study | SouthAmerican | Sub | 1980 | T=0.4475 | G=0.5525 |
| The PAGE Study | NativeAmerican | Sub | 1258 | T=0.5851 | G=0.4149 |
| The PAGE Study | SouthAsian | Sub | 856 | T=0.482 | G=0.518 |
| Allele Frequency Aggregator | Total | Global | 41512 | T=0.68147 | A=0.00000, G=0.31853 |
| Allele Frequency Aggregator | European | Sub | 28262 | T=0.68014 | A=0.00000, G=0.31986 |
| Allele Frequency Aggregator | African | Sub | 4982 | T=0.9291 | A=0.0000, G=0.0709 |
| Allele Frequency Aggregator | Latin American 2 | Sub | 4210 | T=0.4264 | A=0.0000, G=0.5736 |
| Allele Frequency Aggregator | Other | Sub | 3086 | T=0.6633 | A=0.0000, G=0.3367 |
| Allele Frequency Aggregator | Latin American 1 | Sub | 488 | T=0.717 | A=0.000, G=0.283 |
| Allele Frequency Aggregator | Asian | Sub | 388 | T=0.492 | A=0.000, G=0.508 |
| Allele Frequency Aggregator | South Asian | Sub | 96 | T=0.57 | A=0.00, G=0.43 |
| 14KJPN | JAPANESE | Study-wide | 28230 | T=0.44676 | G=0.55324 |
| 8.3KJPN | JAPANESE | Study-wide | 16754 | T=0.45291 | G=0.54709 |
| 1000Genomes_30x | Global | Study-wide | 6404 | T=0.6438 | G=0.3562 |
| 1000Genomes_30x | African | Sub | 1786 | T=0.9233 | G=0.0767 |
| 1000Genomes_30x | Europe | Sub | 1266 | T=0.6493 | G=0.3507 |
| 1000Genomes_30x | South Asian | Sub | 1202 | T=0.4800 | G=0.5200 |
| 1000Genomes_30x | East Asian | Sub | 1170 | T=0.4650 | G=0.5350 |
| 1000Genomes_30x | American | Sub | 980 | T=0.542 | G=0.458 |
| 1000Genomes | Global | Study-wide | 5008 | T=0.6334 | G=0.3666 |
| 1000Genomes | African | Sub | 1322 | T=0.9266 | G=0.0734 |
| 1000Genomes | East Asian | Sub | 1008 | T=0.4623 | G=0.5377 |
| 1000Genomes | Europe | Sub | 1006 | T=0.6451 | G=0.3549 |
| 1000Genomes | South Asian | Sub | 978 | T=0.472 | G=0.528 |
| 1000Genomes | American | Sub | 694 | T=0.533 | G=0.467 |
| Genetic variation in the Estonian population | Estonian | Study-wide | 4480 | T=0.6567 | G=0.3433 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | T=0.6380 | G=0.3620 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | T=0.6486 | G=0.3514 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2916 | T=0.4482 | G=0.5518 |
| Korean Genome Project | KOREAN | Study-wide | 1828 | T=0.4431 | G=0.5569 |
| Northern Sweden | ACPOP | Study-wide | 600 | T=0.630 | G=0.370 |
| SGDP_PRJ | Global | Study-wide | 370 | T=0.330 | G=0.670 |
| Qatari | Global | Study-wide | 216 | T=0.523 | G=0.477 |
| A Vietnamese Genetic Variation Database | Global | Study-wide | 206 | T=0.466 | G=0.534 |
| Siberian | Global | Study-wide | 54 | T=0.30 | G=0.70 |
| The Danish reference pan genome | Danish | Study-wide | 40 | T=0.65 | G=0.35 |
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.68808800T>A |
| GRCh38.p14 chr 12 | NC_000012.12:g.68808800T>G |
| GRCh37.p13 chr 12 | NC_000012.11:g.69202580T>A |
| GRCh37.p13 chr 12 | NC_000012.11:g.69202580T>G |
| MDM2 RefSeqGene | NG_016708.1:g.5610T>A |
| MDM2 RefSeqGene | NG_016708.1:g.5610T>G |
Gene: MDM2, MDM2 proto-oncogene
(plus strand)
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| MDM2 transcript variant 2 | NM_001145339.2:c.14+309T>A | N/A | Intron Variant |
| MDM2 transcript variant 1 | NM_002392.6:c.14+309T>A | N/A | Intron Variant |
| MDM2 transcript variant 3 | NM_001145337.3:c. | N/A | Genic Upstream Transcript Variant |
| MDM2 transcript variant 4 | NM_001145340.3:c. | N/A | Genic Upstream Transcript Variant |
| MDM2 transcript variant 5 | NM_001278462.2:c. | N/A | Genic Upstream Transcript Variant |
| MDM2 transcript variant 6 | NM_001367990.1:c. | N/A | Genic Upstream Transcript Variant |
| MDM2 transcript variant X1 | XM_047428853.1:c. | N/A | Genic Upstream Transcript Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Allele: G (allele ID:
28943
)
| ClinVar Accession | Disease Names | Clinical Significance |
|---|---|---|
| RCV000014918.8 | Accelerated tumor formation, susceptibility to | Benign |
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | T= | A | G |
|---|---|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.68808800= | NC_000012.12:g.68808800T>A | NC_000012.12:g.68808800T>G |
| GRCh37.p13 chr 12 | NC_000012.11:g.69202580= | NC_000012.11:g.69202580T>A | NC_000012.11:g.69202580T>G |
| MDM2 RefSeqGene | NG_016708.1:g.5610= | NG_016708.1:g.5610T>A | NG_016708.1:g.5610T>G |
| MDM2 transcript variant 2 | NM_001145339.2:c.14+309= | NM_001145339.2:c.14+309T>A | NM_001145339.2:c.14+309T>G |
| MDM2 transcript variant 1 | NM_002392.5:c.14+309= | NM_002392.5:c.14+309T>A | NM_002392.5:c.14+309T>G |
| MDM2 transcript variant 1 | NM_002392.6:c.14+309= | NM_002392.6:c.14+309T>A | NM_002392.6:c.14+309T>G |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
68 SubSNP,
19 Frequency,
1 ClinVar
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | YUSUKE | ss3217515 | Sep 28, 2001 (100) |
| 2 | SC_SNP | ss16186292 | Feb 27, 2004 (120) |
| 3 | BGI | ss106813641 | Feb 06, 2009 (130) |
| 4 | ENSEMBL | ss142671014 | Dec 01, 2009 (131) |
| 5 | ILLUMINA | ss160527480 | Dec 01, 2009 (131) |
| 6 | 1000GENOMES | ss225811976 | Jul 14, 2010 (132) |
| 7 | 1000GENOMES | ss235977224 | Jul 15, 2010 (132) |
| 8 | 1000GENOMES | ss242529112 | Jul 15, 2010 (132) |
| 9 | BL | ss255200752 | May 09, 2011 (134) |
| 10 | GMI | ss281442462 | May 04, 2012 (137) |
| 11 | GMI | ss286581095 | Apr 25, 2013 (138) |
| 12 | PJP | ss291274869 | May 09, 2011 (134) |
| 13 | BASICKPUM | ss410758786 | Sep 17, 2011 (135) |
| 14 | ILLUMINA | ss481324245 | Sep 08, 2015 (146) |
| 15 | TISHKOFF | ss563233875 | Apr 25, 2013 (138) |
| 16 | SSMP | ss658798560 | Apr 25, 2013 (138) |
| 17 | EVA-GONL | ss989654883 | Aug 21, 2014 (142) |
| 18 | JMKIDD_LAB | ss1078547831 | Aug 21, 2014 (142) |
| 19 | 1000GENOMES | ss1345487914 | Aug 21, 2014 (142) |
| 20 | DDI | ss1426968526 | Apr 01, 2015 (144) |
| 21 | OMIM-CURATED-RECORDS | ss1505810931 | Dec 08, 2014 (142) |
| 22 | EVA_GENOME_DK | ss1576350634 | Apr 01, 2015 (144) |
| 23 | EVA_DECODE | ss1599332826 | Apr 01, 2015 (144) |
| 24 | EVA_UK10K_ALSPAC | ss1628834911 | Apr 01, 2015 (144) |
| 25 | EVA_UK10K_TWINSUK | ss1671828944 | Apr 01, 2015 (144) |
| 26 | WEILL_CORNELL_DGM | ss1933018532 | Feb 12, 2016 (147) |
| 27 | ILLUMINA | ss1959445207 | Feb 12, 2016 (147) |
| 28 | JJLAB | ss2027259521 | Sep 14, 2016 (149) |
| 29 | USC_VALOUEV | ss2155602191 | Dec 20, 2016 (150) |
| 30 | HUMAN_LONGEVITY | ss2190757598 | Dec 20, 2016 (150) |
| 31 | SYSTEMSBIOZJU | ss2628112533 | Nov 08, 2017 (151) |
| 32 | GRF | ss2699951849 | Nov 08, 2017 (151) |
| 33 | GNOMAD | ss2911874906 | Nov 08, 2017 (151) |
| 34 | SWEGEN | ss3009882946 | Nov 08, 2017 (151) |
| 35 | ILLUMINA | ss3021442265 | Nov 08, 2017 (151) |
| 36 | CSHL | ss3350117479 | Nov 08, 2017 (151) |
| 37 | ILLUMINA | ss3636196267 | Oct 12, 2018 (152) |
| 38 | OMUKHERJEE_ADBS | ss3646444497 | Oct 12, 2018 (152) |
| 39 | URBANLAB | ss3649863054 | Oct 12, 2018 (152) |
| 40 | ILLUMINA | ss3651822863 | Oct 12, 2018 (152) |
| 41 | EGCUT_WGS | ss3677153627 | Jul 13, 2019 (153) |
| 42 | EVA_DECODE | ss3693900575 | Jul 13, 2019 (153) |
| 43 | ILLUMINA | ss3725335407 | Jul 13, 2019 (153) |
| 44 | ACPOP | ss3739123511 | Jul 13, 2019 (153) |
| 45 | EVA | ss3750620271 | Jul 13, 2019 (153) |
| 46 | PAGE_CC | ss3771699642 | Jul 13, 2019 (153) |
| 47 | PACBIO | ss3787258829 | Jul 13, 2019 (153) |
| 48 | PACBIO | ss3792354808 | Jul 13, 2019 (153) |
| 49 | PACBIO | ss3797237657 | Jul 13, 2019 (153) |
| 50 | KHV_HUMAN_GENOMES | ss3815952605 | Jul 13, 2019 (153) |
| 51 | EVA | ss3833181082 | Apr 27, 2020 (154) |
| 52 | SGDP_PRJ | ss3878519555 | Apr 27, 2020 (154) |
| 53 | KRGDB | ss3927187736 | Apr 27, 2020 (154) |
| 54 | KOGIC | ss3972170060 | Apr 27, 2020 (154) |
| 55 | TOPMED | ss4922499181 | Apr 26, 2021 (155) |
| 56 | TOMMO_GENOMICS | ss5206862950 | Apr 26, 2021 (155) |
| 57 | 1000G_HIGH_COVERAGE | ss5291225438 | Oct 16, 2022 (156) |
| 58 | EVA | ss5406391056 | Oct 16, 2022 (156) |
| 59 | HUGCELL_USP | ss5485928498 | Oct 16, 2022 (156) |
| 60 | EVA | ss5510744226 | Oct 16, 2022 (156) |
| 61 | 1000G_HIGH_COVERAGE | ss5588923654 | Oct 16, 2022 (156) |
| 62 | SANFORD_IMAGENETICS | ss5653386634 | Oct 16, 2022 (156) |
| 63 | TOMMO_GENOMICS | ss5756814607 | Oct 16, 2022 (156) |
| 64 | YY_MCH | ss5813399829 | Oct 16, 2022 (156) |
| 65 | EVA | ss5838124195 | Oct 16, 2022 (156) |
| 66 | EVA | ss5850429169 | Oct 16, 2022 (156) |
| 67 | EVA | ss5904862070 | Oct 16, 2022 (156) |
| 68 | EVA | ss5944758571 | Oct 16, 2022 (156) |
| 69 | 1000Genomes | NC_000012.11 - 69202580 | Oct 12, 2018 (152) |
| 70 | 1000Genomes_30x | NC_000012.12 - 68808800 | Oct 16, 2022 (156) |
| 71 | The Avon Longitudinal Study of Parents and Children | NC_000012.11 - 69202580 | Oct 12, 2018 (152) |
| 72 | Genetic variation in the Estonian population | NC_000012.11 - 69202580 | Oct 12, 2018 (152) |
| 73 | The Danish reference pan genome | NC_000012.11 - 69202580 | Apr 27, 2020 (154) |
| 74 | gnomAD - Genomes | NC_000012.12 - 68808800 | Apr 26, 2021 (155) |
| 75 | KOREAN population from KRGDB | NC_000012.11 - 69202580 | Apr 27, 2020 (154) |
| 76 | Korean Genome Project | NC_000012.12 - 68808800 | Apr 27, 2020 (154) |
| 77 | Northern Sweden | NC_000012.11 - 69202580 | Jul 13, 2019 (153) |
| 78 | The PAGE Study | NC_000012.12 - 68808800 | Jul 13, 2019 (153) |
| 79 | Qatari | NC_000012.11 - 69202580 | Apr 27, 2020 (154) |
| 80 | SGDP_PRJ | NC_000012.11 - 69202580 | Apr 27, 2020 (154) |
| 81 | Siberian | NC_000012.11 - 69202580 | Apr 27, 2020 (154) |
| 82 | 8.3KJPN | NC_000012.11 - 69202580 | Apr 26, 2021 (155) |
| 83 | 14KJPN | NC_000012.12 - 68808800 | Oct 16, 2022 (156) |
| 84 | TopMed | NC_000012.12 - 68808800 | Apr 26, 2021 (155) |
| 85 | UK 10K study - Twins | NC_000012.11 - 69202580 | Oct 12, 2018 (152) |
| 86 | A Vietnamese Genetic Variation Database | NC_000012.11 - 69202580 | Jul 13, 2019 (153) |
| 87 | ALFA | NC_000012.12 - 68808800 | Apr 26, 2021 (155) |
| 88 | ClinVar | RCV000014918.8 | Oct 16, 2022 (156) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| 9737989705 | NC_000012.12:68808799:T:A | NC_000012.12:68808799:T:A | (self) |
| ss255200752, ss281442462, ss286581095, ss291274869, ss1599332826 | NC_000012.10:67488846:T:G | NC_000012.12:68808799:T:G | (self) |
| 58254299, 32343942, 22891875, 3009197, 34365130, 12408376, 15060462, 30536535, 8118545, 64832257, 32343942, 7177827, ss225811976, ss235977224, ss242529112, ss481324245, ss563233875, ss658798560, ss989654883, ss1078547831, ss1345487914, ss1426968526, ss1576350634, ss1628834911, ss1671828944, ss1933018532, ss1959445207, ss2027259521, ss2155602191, ss2628112533, ss2699951849, ss2911874906, ss3009882946, ss3021442265, ss3350117479, ss3636196267, ss3646444497, ss3651822863, ss3677153627, ss3739123511, ss3750620271, ss3787258829, ss3792354808, ss3797237657, ss3833181082, ss3878519555, ss3927187736, ss5206862950, ss5406391056, ss5510744226, ss5653386634, ss5838124195, ss5944758571 | NC_000012.11:69202579:T:G | NC_000012.12:68808799:T:G | (self) |
| RCV000014918.8, 76449589, 410827281, 28548061, 921111, 90651711, 138044838, 9737989705, ss1505810931, ss2190757598, ss3649863054, ss3693900575, ss3725335407, ss3771699642, ss3815952605, ss3972170060, ss4922499181, ss5291225438, ss5485928498, ss5588923654, ss5756814607, ss5813399829, ss5850429169, ss5904862070 | NC_000012.12:68808799:T:G | NC_000012.12:68808799:T:G | (self) |
| ss16186292 | NT_029419.10:31345885:T:G | NC_000012.12:68808799:T:G | (self) |
| ss3217515, ss106813641, ss142671014, ss160527480, ss410758786 | NT_029419.12:31345885:T:G | NC_000012.12:68808799:T:G | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
149
citations for rs2279744
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 15550242 | A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. | Bond GL et al. | 2004 | Cell |
| 16258005 | Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome. | Bougeard G et al. | 2006 | Journal of medical genetics |
| 16287156 | Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. | Zhang X et al. | 2006 | Human mutation |
| 17003841 | The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes. | Ruijs MW et al. | 2007 | European journal of human genetics |
| 17360557 | Haplotype structure and selection of the MDM2 oncogene in humans. | Atwal GS et al. | 2007 | Proceedings of the National Academy of Sciences of the United States of America |
| 17537232 | Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients. | Toyama T et al. | 2007 | Breast cancer research |
| 17634539 | MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma. | Hirata H et al. | 2007 | Clinical cancer research |
| 17957785 | Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. | Liu G et al. | 2008 | International journal of cancer |
| 18332046 | A distinct ERCC1 haplotype is associated with mRNA expression levels in prostate cancer patients. | Woelfelschneider A et al. | 2008 | Carcinogenesis |
| 18433484 | Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene. | Mittelstrass K et al. | 2008 | BMC cancer |
| 18433491 | MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European Caucasians. | Bittenbring J et al. | 2008 | BMC cancer |
| 18798306 | Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population. | Pangilinan F et al. | 2008 | American journal of medical genetics. Part A |
| 19193430 | Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer. | Ashton KA et al. | 2009 | Gynecologic oncology |
| 19237173 | Bcl2 -938C/A polymorphism carries increased risk of biochemical recurrence after radical prostatectomy. | Hirata H et al. | 2009 | The Journal of urology |
| 19302219 | p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma. | Liu G et al. | 2010 | Diseases of the esophagus |
| 19442035 | Pharmacogenomics of platinum-based chemotherapy in NSCLC. | Hildebrandt MA et al. | 2009 | Expert opinion on drug metabolism & toxicology |
| 19470478 | Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans. | Kang HJ et al. | 2009 | Proceedings of the National Academy of Sciences of the United States of America |
| 19497887 | Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene. | Atwal GS et al. | 2009 | Proceedings of the National Academy of Sciences of the United States of America |
| 19521721 | Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. | Hancox RJ et al. | 2009 | Human genetics |
| 19542078 | TP53 PIN3 and MDM2 SNP309 polymorphisms as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis. | Marcel V et al. | 2009 | Journal of medical genetics |
| 19707196 | The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. | Sinilnikova OM et al. | 2009 | British journal of cancer |
| 19751436 | Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients. | Wang X et al. | 2009 | Helicobacter |
| 19837266 | TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility. | Do TN et al. | 2009 | Cancer genetics and cytogenetics |
| 20200430 | TP53, MDM2, NQO1, and susceptibility to cervical cancer. | Hu X et al. | 2010 | Cancer epidemiology, biomarkers & prevention |
| 20447891 | MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population. | Akkiz H et al. | 2010 | Cancer epidemiology |
| 20452958 | Single-nucleotide polymorphisms in the p53 signaling pathway. | Grochola LF et al. | 2010 | Cold Spring Harbor perspectives in biology |
| 20587610 | Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. | Ucisik-Akkaya E et al. | 2010 | Molecular human reproduction |
| 20617153 | Detection of fetomaternal genotype associations in early-onset disorders: evaluation of different methods and their application to childhood leukemia. | Healy J et al. | 2010 | Journal of biomedicine & biotechnology |
| 20736372 | Human papillomavirus seropositivity synergizes with MDM2 variants to increase the risk of oral squamous cell carcinoma. | Chen X et al. | 2010 | Cancer research |
| 20855462 | Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population. | Sun T et al. | 2010 | Clinical cancer research |
| 20922573 | Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus. | Boonstra JJ et al. | 2011 | Journal of gastrointestinal surgery |
| 20979563 | MDM2 and CDKN1A gene polymorphisms and risk of Kaposi's sarcoma in African and Caucasian patients. | Tornesello ML et al. | 2011 | Biomarkers |
| 21051655 | MDM2 as a modifier gene in retinoblastoma. | Castéra L et al. | 2010 | Journal of the National Cancer Institute |
| 21240526 | Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review. | Jin F et al. | 2011 | Journal of cancer research and clinical oncology |
| 21268124 | MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese. | Dong J et al. | 2011 | Molecular carcinogenesis |
| 21305319 | Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. | Wu CC et al. | 2011 | Human genetics |
| 21402718 | Regulation of female reproduction by p53 and its family members. | Feng Z et al. | 2011 | FASEB journal |
| 21437228 | Using epidemiology and genomics to understand osteosarcoma etiology. | Savage SA et al. | 2011 | Sarcoma |
| 21514219 | Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. | Zhang B et al. | 2011 | The Lancet. Oncology |
| 21540763 | Polymorphisms of MDM4 and risk of squamous cell carcinoma of the head and neck. | Yu H et al. | 2011 | Pharmacogenetics and genomics |
| 21619704 | A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma. | Mirabello L et al. | 2011 | BMC cancer |
| 21656578 | Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck. | Yu H et al. | 2011 | Molecular carcinogenesis |
| 21779510 | Regulation of Fertility by the p53 Family Members. | Hu W et al. | 2011 | Genes & cancer |
| 21841506 | Combined effect of genetic polymorphisms in P53, P73, and MDM2 on non-small cell lung cancer survival. | Liu L et al. | 2011 | Journal of thoracic oncology |
| 21877955 | Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia. | Al-Hadyan KS et al. | 2012 | Genetic testing and molecular biomarkers |
| 22004425 | Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. | Tomoda T et al. | 2012 | Journal of gastroenterology and hepatology |
| 22052649 | Combined p53-related genetic variants together with HPV infection increase oral cancer risk. | Wang Z et al. | 2012 | International journal of cancer |
| 22180099 | Influence of MDM2 and MDM4 on development and survival in hereditary retinoblastoma. | de Oliveira Reis AH et al. | 2012 | Pediatric blood & cancer |
| 22251423 | NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction. | Leander K et al. | 2012 | Clinica chimica acta; international journal of clinical chemistry |
| 22300735 | Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors. | Hildesheim A et al. | 2012 | Seminars in cancer biology |
| 22347493 | Genetic variation in cell death genes and risk of non-Hodgkin lymphoma. | Schuetz JM et al. | 2012 | PloS one |
| 22916154 | Analysis of MDM2 and MDM4 single nucleotide polymorphisms, mRNA splicing and protein expression in retinoblastoma. | McEvoy J et al. | 2012 | PloS one |
| 23145162 | Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma. | Jin L et al. | 2012 | PloS one |
| 23210739 | Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma. | Singhal P et al. | 2013 | DNA and cell biology |
| 23218882 | Significance of MDM2 and P14 ARF polymorphisms in susceptibility to differentiated thyroid carcinoma. | Zhang F et al. | 2013 | Surgery |
| 23244604 | Identification of functional DNA variants in the constitutive promoter region of MDM2. | Lalonde ME et al. | 2012 | Human genomics |
| 23423487 | Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy. | Wang S et al. | 2013 | Cancer chemotherapy and pharmacology |
| 23697595 | SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers. | Alsbeih G et al. | 2013 | Radiation oncology (London, England) |
| 23820649 | Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease. | Cooper DN et al. | 2013 | Human genetics |
| 24061636 | Murine double minute 2 rs2279744 polymorphism and hepatocellular carcinoma risk in East Asians: a meta-analysis. | Liu Y et al. | 2014 | Tumour biology |
| 24122202 | Effects of murine double minute 2 polymorphisms on the risk and survival of osteosarcoma: a systemic review and meta-analysis. | Wang L et al. | 2014 | Tumour biology |
| 24205329 | Detection of regulatory SNPs in human genome using ChIP-seq ENCODE data. | Bryzgalov LO et al. | 2013 | PloS one |
| 24293392 | MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis. | Wang LH et al. | 2014 | Tumour biology |
| 24340057 | Genetic variations in radiation and chemotherapy drug action pathways and survival in locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy. | Liu H et al. | 2013 | PloS one |
| 24435975 | p53 signaling pathway polymorphisms associated to recurrent pregnancy loss. | Fraga LR et al. | 2014 | Molecular biology reports |
| 24586820 | Evidence for an epistatic effect between TP53 R72P and MDM2 T309G SNPs in HIV infection: a cross-sectional study in women from South Brazil. | Hartwig FP et al. | 2014 | PloS one |
| 24654968 | Germline genetics of the p53 pathway affect longevity in a gender specific manner. | Groß S et al. | 2014 | Current aging science |
| 24792886 | Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies. | Zhao Y et al. | 2014 | Tumour biology |
| 24797837 | MDM2 SNP309 polymorphism is associated with colorectal cancer risk. | Wang W et al. | 2014 | Scientific reports |
| 25054017 | Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk. | Enokida Y et al. | 2014 | Biomedical reports |
| 25214541 | A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. | Findlay JM et al. | 2015 | Annals of oncology |
| 25316267 | TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal women. | Zając A et al. | 2014 | Medical oncology (Northwood, London, England) |
| 25366142 | Impact of MDM2 gene polymorphism on sarcoma risk. | Zhang D et al. | 2015 | Tumour biology |
| 25412941 | Association between polymorphisms in tumor suppressor genes and oncogenes and risk of hepatocellular carcinoma: a case-control study in an HCC epidemic area within the Han Chinese population. | Su C et al. | 2014 | Medical oncology (Northwood, London, England) |
| 25431177 | Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon. | Gansmo LB et al. | 2015 | International journal of cancer |
| 25479941 | Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population. | Wu GC et al. | 2015 | Medical oncology (Northwood, London, England) |
| 25511444 | Age-dependent association of MDM2 promoter polymorphisms and uterine leiomyoma in South-East Iran: A preliminary report. | Salimi S et al. | 2015 | The journal of obstetrics and gynaecology research |
| 25734904 | Impact of TP53 codon 72 and MDM2 SNP 309 polymorphisms in pancreatic ductal adenocarcinoma. | Hori Y et al. | 2015 | PloS one |
| 25928231 | Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis. | Wang S et al. | 2015 | BMC medical genetics |
| 26025918 | MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer. | Xue L et al. | 2016 | Oncotarget |
| 26135929 | A Systematic Review and Meta-Analysis of Three Gene Variants Association with Risk of Prostate Cancer: An Update. | Chen Y et al. | 2015 | Urology journal |
| 26224627 | Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis. | Roszak A et al. | 2015 | Molecular diagnosis & therapy |
| 26289323 | Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population. | Chen R et al. | 2015 | Scientific reports |
| 26382048 | Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes. | Jacovas VC et al. | 2015 | PloS one |
| 26471763 | MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk. | Gansmo LB et al. | 2015 | Cancer medicine |
| 26672516 | Association between MDM2 SNP309 T>G polymorphism and the risk of bladder cancer: new data in a Chinese population and an updated meta-analysis. | Xie L et al. | 2015 | OncoTargets and therapy |
| 26867771 | The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer. | Gansmo LB et al. | 2016 | Tumour biology |
| 26945408 | Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals. | Zhuo X et al. | 2016 | Medicine |
| 26967244 | Systematic meta-analyses of gene-specific genetic association studies in prostate cancer. | Hao Q et al. | 2016 | Oncotarget |
| 27228500 | Prognostic potential of the MDM2 309T>G polymorphism in stage I lung adenocarcinoma. | Enokida Y et al. | 2016 | Cancer medicine |
| 27246533 | The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC. | Wang C et al. | 2016 | Scientific reports |
| 27330794 | Association of MDM2 promoter T309G polymorphism with oral cancer risk: A meta-analysis of 3,536 subjects. | Yang XI et al. | 2016 | Molecular and clinical oncology |
| 27438225 | A systematic review and meta-analysis of MDM2 polymorphisms in osteosarcoma susceptibility. | Bilbao-Aldaiturriaga N et al. | 2016 | Pediatric research |
| 27506496 | A Functional Polymorphism (rs937283) in the MDM2 Promoter Region is Associated with Poor Prognosis of Retinoblastoma in Chinese Han Population. | Jiao Y et al. | 2016 | Scientific reports |
| 27588484 | Gene-gene interactions in gastrointestinal cancer susceptibility. | Kim J et al. | 2016 | Oncotarget |
| 27608007 | Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients. | Dreussi E et al. | 2016 | International journal of molecular sciences |
| 27624283 | MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer. | Helwa R et al. | 2016 | Scientific reports |
| 27785069 | Influence of MDM2 polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis. | Yu H et al. | 2016 | OncoTargets and therapy |
| 27801956 | Mutations in apoptotic genes and micronucleus occurrence in vinyl chloride-exposed workers in China. | Feng N et al. | 2017 | Environmental and molecular mutagenesis |
| 28083704 | MDM2 gene polymorphisms and risk of classic Kaposi's sarcoma among Iranian patients. | Varmazyar S et al. | 2017 | Medical microbiology and immunology |
| 28158999 | MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. | Gansmo LB et al. | 2017 | BMC cancer |
| 28324443 | Among 45 variants in 11 genes, HDM2 promoter polymorphisms emerge as new candidate biomarker associated with radiation toxicity. | Alsbeih G et al. | 2014 | 3 Biotech |
| 28351583 | Candidate apoptotic and DNA repair gene approach confirms involvement of ERCC1, ERCC5, TP53 and MDM2 in radiation-induced toxicity in head and neck cancer. | Borchiellini D et al. | 2017 | Oral oncology |
| 28676527 | The ID genotype of MDM2 40 bp insertion/deletion polymorphism was associated with lower risk of SLE. | Salimi S et al. | 2017 | Postgraduate medical journal |
| 28756477 | p53 signaling pathway polymorphisms, cancer risk and tumor phenotype in TP53 R337H mutation carriers. | Macedo GS et al. | 2018 | Familial cancer |
| 28827732 | Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies. | Wang J et al. | 2017 | Scientific reports |
| 28881764 | Detection of nasopharyngeal carcinoma susceptibility with single nucleotide polymorphism analysis using next-generation sequencing technology. | Wu MY et al. | 2017 | Oncotarget |
| 29090237 | Lack of an Association between a Functional Polymorphism in the MDM2 Promoter and Breast Cancer in Women in Northeast Iran. | Tavakkol Afshari Z et al. | 2017 | Reports of biochemistry & molecular biology |
| 29096752 | The association between murine double minute 2 (MDM2) rs2279744 and endometrial cancer risk in a Chinese Han population. | Wu JP et al. | 2017 | Cellular and molecular biology (Noisy-le-Grand, France) |
| 29181159 | Investigation of the association between the MDM2 T309G polymorphism and gastric cancer. | Tas A et al. | 2017 | Biomedical reports |
| 29480845 | Association of rs2279744 and rs117039649 promoter polymorphism with the risk of gynecological cancer: A meta-analysis of case-control studies. | Zhang J et al. | 2018 | Medicine |
| 29699057 | Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population. | Yilmaz M et al. | 2018 | Asian Pacific journal of cancer prevention |
| 29957069 | Associations Between TP53 and MDM2 Polymorphisms and the Follicle-Stimulating Hormone/Luteinizing Hormone Ratio in Infertile Women. | Chan Y et al. | 2018 | Genetic testing and molecular biomarkers |
| 30194081 | Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan. | Yueh TC et al. | 2018 | Cancer genomics & proteomics |
| 30337837 | Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis. | Wen J et al. | 2018 | Cancer cell international |
| 30355102 | Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. | Rodríguez C et al. | 2018 | Stroke |
| 30544467 | Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility. | Cao Q et al. | 2018 | Medicine |
| 30548972 | Role of MDM2 309T>G (rs2279744) and I/D (rs3730485) polymorphisms and haplotypes in risk of papillary thyroid carcinoma, tumor stage, tumor size, and early onset of tumor: A case control study. | Maruei-Milan R et al. | 2019 | Journal of cellular physiology |
| 30691044 | Association of the MDM2 SNP285 and SNP309 Genetic Variants with the Risk, Age at Onset and Prognosis of Breast Cancer in Central European Women: A Hospital-Based Case-Control Study. | Miedl H et al. | 2019 | International journal of molecular sciences |
| 30695351 | [ASSOCIATION OF CERTAIN SINGLE NUCLEOTIDE POLYMORPHISM GENES OF APOPTOSIS SYSTEM WITH A RISK OF DEVELOPMENT OF COLORECTAL CANCER IN RUSSIAN POPULATION]. | Alyeva MK et al. | 2016 | Zhurnal mikrobiologii, epidemiologii i immunobiologii |
| 30793520 | Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies. | Tian J et al. | 2019 | Cancer medicine |
| 30956778 | Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients. | Bauer M et al. | 2019 | Oncotarget |
| 30959967 | Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population. | Fernández-Mateos J et al. | 2019 | Cancers |
| 30972159 | Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus. | Pan Q et al. | 2019 | American journal of translational research |
| 31211452 | Long telomeres cooperate with p53, MDM2, and p21 polymorphisms to raise pediatric solid tumor risk. | Borbora D et al. | 2019 | Pediatrics international |
| 31326197 | Association of MDM2 gene SNP 309 polymorphism and human non-small cell lung cancer susceptibility: A meta-analysis. | Luan L et al. | 2019 | Pathology, research and practice |
| 31350972 | Association of PIK3CA and MDM2 SNP309 with Cervical Squamous Cell Carcinoma in a Philippine Population. | Tantengco OAG et al. | 2019 | Asian Pacific journal of cancer prevention |
| 31424672 | Significant association between MDM2 T309G polymorphism and colorectal cancer. | Atabey M et al. | 2019 | Journal of B.U.ON. |
| 31612033 | The complementary effect of rs1042522 in TP53 and rs1805007 in MC1R is associated with an elevated risk of cutaneous melanoma in Latvian population. | Ozola A et al. | 2019 | Oncology letters |
| 31653152 | Association of Mouse Double Minute 2 -309T>G Polymorphism with Acute Myeloid Leukemia in an Iranian Population: A Case- Control Study. | Soleymannejad M et al. | 2019 | Asian Pacific journal of cancer prevention |
| 31909567 | Interactions among variants in P53 apoptotic pathway genes are associated with neurologic deterioration and functional outcome after acute ischemic stroke. | Yi X et al. | 2021 | Brain and behavior |
| 31935498 | A comprehensive evaluation of single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Asian populations: A systematic review and network meta-analysis. | Zhang C et al. | 2020 | Gene |
| 32001373 | Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: An updated meta-analysis based on 59 case-control studies. | Elshazli RM et al. | 2020 | Gene |
| 32066633 | Association between genetic polymorphisms and endometrial cancer risk: a systematic review. | Bafligil C et al. | 2020 | Journal of medical genetics |
| 32354891 | Association of Murine Double Minute 2 Genotypes and Lung Cancer Risk. | Lin YC et al. | 2020 | In vivo (Athens, Greece) |
| 32392664 | A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population. | Reza HA et al. | 2020 | The Korean journal of internal medicine |
| 32424731 | Study of the MDM2 -410T-G polymorphism (rs2279744) by pyrosequencing in mothers of Down Syndrome subjects. | Salemi M et al. | 2020 | Human cell |
| 32492903 | Association Analysis of TP53 rs1042522, MDM2 rs2279744, rs3730485, MDM4 rs4245739 Variants and Acute Myeloid Leukemia Susceptibility, Risk Stratification Scores, and Clinical Features: An Exploratory Study. | Tripon F et al. | 2020 | Journal of clinical medicine |
| 32821748 | Evaluation of TP53 Codon 72, P21 Codon 31, and MDM2 SNP309 Polymorphisms in Iranian Patients with Acute Lymphocytic Leukemia. | Lotfi Garavand A et al. | 2020 | Reports of biochemistry & molecular biology |
| 33109563 | Association of MDM2 T309G (rs2279744) Polymorphism and Expression Changes With Risk of Prostate Cancer in the Slovak Population. | Sivonova MK et al. | 2020 | Anticancer research |
| 33262486 | Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters. | 2020 | European journal of human genetics | |
| 33669778 | Associations of MDM2 and MDM4 Polymorphisms with Early-Stage Breast Cancer. | Bartnykaitė A et al. | 2021 | Journal of clinical medicine |
| 33959694 | The cell cycle regulatory gene polymorphisms TP53 (rs1042522) and MDM2 (rs2279744) in lung cancer: a meta-analysis. | Bulgakova O et al. | 2020 | Vavilovskii zhurnal genetiki i selektsii |
| 34077778 | Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis. | Gansmo LB et al. | 2021 | Gene |
| 34257965 | Association of Murine Double Minute 2 polymorphisms with gastric cancer: A systematic review with meta-analysis. | Timóteo M et al. | 2021 | Biomedical reports |
| 34540891 | Umbrella Review on Associations Between Single Nucleotide Polymorphisms and Lung Cancer Risk. | Li X et al. | 2021 | Frontiers in molecular biosciences |
| 35342856 | Association between ТР53, MDM2 and NQO1 gene polymorphisms and viral load among women with human papillomavirus. | AlBosale AH et al. | 2022 | Vavilovskii zhurnal genetiki i selektsii |
| 36039053 | Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women. | Floris M et al. | 2022 | Oncology letters |
| 36059664 | Associations of MDM2 rs2279744 and TP53 rs1042522 polymorphisms with cervical cancer risk: A meta-analysis and systematic review. | Yu M et al. | 2022 | Frontiers in oncology |
Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
Genome context:
Select flank length:
Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.