dbSNP Short Genetic Variations
Welcome to the Reference SNP (rs) Report
All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.
Reference SNP (rs) Report
This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.
rs671
Current Build 156
Released September 21, 2022
- Organism
- Homo sapiens
- Position
-
chr12:111803962 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
- Alleles
- G>A
- Variation Type
- SNV Single Nucleotide Variation
- Frequency
-
A=0.006055 (1921/317236, ALFA)A=0.008958 (2371/264690, TOPMED)A=0.018882 (4582/242666, GnomAD_exome) (+ 17 more)
- Clinical Significance
- Reported in ClinVar
- Gene : Consequence
- ALDH2 : Missense Variant
- Publications
- 293 citations
- Genomic View
- See rs on genome
ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.
Release Version: 20231103111315
| Population | Group | Sample Size | Ref Allele | Alt Allele | Ref HMOZ | Alt HMOZ | HTRZ | HWEP |
|---|---|---|---|---|---|---|---|---|
| Total | Global | 317358 | G=0.993947 | A=0.006053 | 0.989274 | 0.00138 | 0.009346 | 32 |
| European | Sub | 273742 | G=0.999927 | A=0.000073 | 0.999861 | 0.000007 | 0.000132 | 32 |
| African | Sub | 8526 | G=0.9995 | A=0.0005 | 0.999062 | 0.0 | 0.000938 | 0 |
| African Others | Sub | 304 | G=0.997 | A=0.003 | 0.993421 | 0.0 | 0.006579 | 0 |
| African American | Sub | 8222 | G=0.9996 | A=0.0004 | 0.99927 | 0.0 | 0.00073 | 0 |
| Asian | Sub | 6806 | G=0.8008 | A=0.1992 | 0.646488 | 0.04496 | 0.308551 | 2 |
| East Asian | Sub | 4902 | G=0.7821 | A=0.2179 | 0.616075 | 0.051816 | 0.332109 | 1 |
| Other Asian | Sub | 1904 | G=0.8487 | A=0.1513 | 0.72479 | 0.027311 | 0.247899 | 1 |
| Latin American 1 | Sub | 1276 | G=1.0000 | A=0.0000 | 1.0 | 0.0 | 0.0 | N/A |
| Latin American 2 | Sub | 1862 | G=0.9995 | A=0.0005 | 0.998926 | 0.0 | 0.001074 | 0 |
| South Asian | Sub | 5218 | G=0.9990 | A=0.0010 | 0.998084 | 0.0 | 0.001916 | 0 |
| Other | Sub | 19928 | G=0.97315 | A=0.02685 | 0.95283 | 0.006523 | 0.040646 | 32 |
Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").
Download| Study | Population | Group | Sample Size | Ref Allele | Alt Allele |
|---|---|---|---|---|---|
| Allele Frequency Aggregator | Total | Global | 317236 | G=0.993945 | A=0.006055 |
| Allele Frequency Aggregator | European | Sub | 273638 | G=0.999927 | A=0.000073 |
| Allele Frequency Aggregator | Other | Sub | 19924 | G=0.97315 | A=0.02685 |
| Allele Frequency Aggregator | African | Sub | 8512 | G=0.9995 | A=0.0005 |
| Allele Frequency Aggregator | Asian | Sub | 6806 | G=0.8008 | A=0.1992 |
| Allele Frequency Aggregator | South Asian | Sub | 5218 | G=0.9990 | A=0.0010 |
| Allele Frequency Aggregator | Latin American 2 | Sub | 1862 | G=0.9995 | A=0.0005 |
| Allele Frequency Aggregator | Latin American 1 | Sub | 1276 | G=1.0000 | A=0.0000 |
| TopMed | Global | Study-wide | 264690 | G=0.991042 | A=0.008958 |
| gnomAD - Exomes | Global | Study-wide | 242666 | G=0.981118 | A=0.018882 |
| gnomAD - Exomes | European | Sub | 130628 | G=0.999969 | A=0.000031 |
| gnomAD - Exomes | Asian | Sub | 47424 | G=0.90450 | A=0.09550 |
| gnomAD - Exomes | American | Sub | 33346 | G=0.99961 | A=0.00039 |
| gnomAD - Exomes | African | Sub | 15428 | G=0.99981 | A=0.00019 |
| gnomAD - Exomes | Ashkenazi Jewish | Sub | 9890 | G=1.0000 | A=0.0000 |
| gnomAD - Exomes | Other | Sub | 5950 | G=0.9945 | A=0.0055 |
| gnomAD - Genomes | Global | Study-wide | 140164 | G=0.994043 | A=0.005957 |
| gnomAD - Genomes | European | Sub | 75918 | G=0.99996 | A=0.00004 |
| gnomAD - Genomes | African | Sub | 42024 | G=0.99983 | A=0.00017 |
| gnomAD - Genomes | American | Sub | 13632 | G=0.99905 | A=0.00095 |
| gnomAD - Genomes | Ashkenazi Jewish | Sub | 3322 | G=1.0000 | A=0.0000 |
| gnomAD - Genomes | East Asian | Sub | 3118 | G=0.7453 | A=0.2547 |
| gnomAD - Genomes | Other | Sub | 2150 | G=0.9916 | A=0.0084 |
| ExAC | Global | Study-wide | 88224 | G=0.97871 | A=0.02129 |
| ExAC | Europe | Sub | 52942 | G=0.99994 | A=0.00006 |
| ExAC | Asian | Sub | 19698 | G=0.90542 | A=0.09458 |
| ExAC | African | Sub | 7614 | G=0.9999 | A=0.0001 |
| ExAC | American | Sub | 7302 | G=0.9989 | A=0.0011 |
| ExAC | Other | Sub | 668 | G=0.996 | A=0.004 |
| The PAGE Study | Global | Study-wide | 78702 | G=0.97283 | A=0.02717 |
| The PAGE Study | AfricanAmerican | Sub | 32516 | G=0.99975 | A=0.00025 |
| The PAGE Study | Mexican | Sub | 10810 | G=0.99917 | A=0.00083 |
| The PAGE Study | Asian | Sub | 8318 | G=0.7870 | A=0.2130 |
| The PAGE Study | PuertoRican | Sub | 7918 | G=0.9999 | A=0.0001 |
| The PAGE Study | NativeHawaiian | Sub | 4534 | G=0.9268 | A=0.0732 |
| The PAGE Study | Cuban | Sub | 4230 | G=0.9981 | A=0.0019 |
| The PAGE Study | Dominican | Sub | 3828 | G=1.0000 | A=0.0000 |
| The PAGE Study | CentralAmerican | Sub | 2450 | G=0.9996 | A=0.0004 |
| The PAGE Study | SouthAmerican | Sub | 1982 | G=0.9970 | A=0.0030 |
| The PAGE Study | NativeAmerican | Sub | 1260 | G=0.9992 | A=0.0008 |
| The PAGE Study | SouthAsian | Sub | 856 | G=1.000 | A=0.000 |
| 14KJPN | JAPANESE | Study-wide | 28258 | G=0.80597 | A=0.19403 |
| 8.3KJPN | JAPANESE | Study-wide | 16760 | G=0.80501 | A=0.19499 |
| 1000Genomes_30x | Global | Study-wide | 6404 | G=0.9664 | A=0.0336 |
| 1000Genomes_30x | African | Sub | 1786 | G=0.9994 | A=0.0006 |
| 1000Genomes_30x | Europe | Sub | 1266 | G=1.0000 | A=0.0000 |
| 1000Genomes_30x | South Asian | Sub | 1202 | G=1.0000 | A=0.0000 |
| 1000Genomes_30x | East Asian | Sub | 1170 | G=0.8197 | A=0.1803 |
| 1000Genomes_30x | American | Sub | 980 | G=0.997 | A=0.003 |
| 1000Genomes | Global | Study-wide | 5008 | G=0.9643 | A=0.0357 |
| 1000Genomes | African | Sub | 1322 | G=0.9985 | A=0.0015 |
| 1000Genomes | East Asian | Sub | 1008 | G=0.8264 | A=0.1736 |
| 1000Genomes | Europe | Sub | 1006 | G=1.0000 | A=0.0000 |
| 1000Genomes | South Asian | Sub | 978 | G=1.000 | A=0.000 |
| 1000Genomes | American | Sub | 694 | G=0.997 | A=0.003 |
| The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | G=0.9990 | A=0.0010 |
| UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | G=1.0000 | A=0.0000 |
| KOREAN population from KRGDB | KOREAN | Study-wide | 2926 | G=0.8274 | A=0.1726 |
| Korean Genome Project | KOREAN | Study-wide | 1832 | G=0.8444 | A=0.1556 |
| Genome-wide autozygosity in Daghestan | Global | Study-wide | 1112 | G=0.9946 | A=0.0054 |
| Genome-wide autozygosity in Daghestan | Daghestan | Sub | 626 | G=0.998 | A=0.002 |
| Genome-wide autozygosity in Daghestan | Near_East | Sub | 138 | G=0.993 | A=0.007 |
| Genome-wide autozygosity in Daghestan | Europe | Sub | 108 | G=1.000 | A=0.000 |
| Genome-wide autozygosity in Daghestan | Central Asia | Sub | 106 | G=0.962 | A=0.038 |
| Genome-wide autozygosity in Daghestan | South Asian | Sub | 98 | G=1.00 | A=0.00 |
| Genome-wide autozygosity in Daghestan | Caucasus | Sub | 36 | G=1.00 | A=0.00 |
| HapMap | Global | Study-wide | 762 | G=0.870 | A=0.130 |
| HapMap | American | Sub | 390 | G=0.874 | A=0.126 |
| HapMap | Asian | Sub | 254 | G=0.803 | A=0.197 |
| HapMap | African | Sub | 118 | G=1.000 | A=0.000 |
| A Vietnamese Genetic Variation Database | Global | Study-wide | 604 | G=0.791 | A=0.209 |
| Ancient Sardinia genome-wide 1240k capture data generation and analysis | Global | Study-wide | 38 | G=1.00 | A=0.00 |
| SGDP_PRJ | Global | Study-wide | 22 | G=0.50 | A=0.50 |
Help
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
Genomic Placements
| Sequence name | Change |
|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.111803962G>A |
| GRCh37.p13 chr 12 | NC_000012.11:g.112241766G>A |
| ALDH2 RefSeqGene | NG_012250.2:g.42076G>A |
Gene: ALDH2, aldehyde dehydrogenase 2 family member
(plus strand)
| Molecule type | Change | Amino acid[Codon] | SO Term |
|---|---|---|---|
| ALDH2 transcript variant 1 | NM_000690.4:c.1510G>A | E [GAA] > K [AAA] | Coding Sequence Variant |
| aldehyde dehydrogenase, mitochondrial isoform 1 precursor | NP_000681.2:p.Glu504Lys | E (Glu) > K (Lys) | Missense Variant |
| ALDH2 transcript variant 2 | NM_001204889.2:c.1369G>A | E [GAA] > K [AAA] | Coding Sequence Variant |
| aldehyde dehydrogenase, mitochondrial isoform 2 precursor | NP_001191818.1:p.Glu457Lys | E (Glu) > K (Lys) | Missense Variant |
Help
Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.
Allele: A (allele ID:
33429
)
| ClinVar Accession | Disease Names | Clinical Significance |
|---|---|---|
| RCV000020058.7 | Alcohol sensitivity, acute | Drug-Response |
| RCV000020059.5 | Alcohol dependence | Protective |
| RCV000020060.5 | Susceptibility to hangover | Risk-Factor |
| RCV000020061.5 | Sublingual nitroglycerin, susceptibility to poor response to | Risk-Factor |
| RCV000020062.5 | Esophageal cancer, alcohol-related, susceptibility to | Risk-Factor |
| RCV001290000.2 | AMED syndrome, digenic | Pathogenic |
| RCV001787815.1 | ethanol response - Toxicity | Drug-Response |
Help
Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
| Placement | G= | A |
|---|---|---|
| GRCh38.p14 chr 12 | NC_000012.12:g.111803962= | NC_000012.12:g.111803962G>A |
| GRCh37.p13 chr 12 | NC_000012.11:g.112241766= | NC_000012.11:g.112241766G>A |
| ALDH2 RefSeqGene | NG_012250.2:g.42076= | NG_012250.2:g.42076G>A |
| ALDH2 transcript variant 1 | NM_000690.4:c.1510= | NM_000690.4:c.1510G>A |
| ALDH2 transcript variant 1 | NM_000690.3:c.1510= | NM_000690.3:c.1510G>A |
| ALDH2 transcript variant 2 | NM_001204889.2:c.1369= | NM_001204889.2:c.1369G>A |
| ALDH2 transcript variant 2 | NM_001204889.1:c.1369= | NM_001204889.1:c.1369G>A |
| aldehyde dehydrogenase, mitochondrial isoform 1 precursor | NP_000681.2:p.Glu504= | NP_000681.2:p.Glu504Lys |
| aldehyde dehydrogenase, mitochondrial isoform 2 precursor | NP_001191818.1:p.Glu457= | NP_001191818.1:p.Glu457Lys |
Help
Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
132 SubSNP,
21 Frequency,
7 ClinVar
submissions
| No | Submitter | Submission ID | Date (Build) |
|---|---|---|---|
| 1 | WIAF | ss676 | Sep 19, 2000 (36) |
| 2 | SNP500CANCER | ss5586234 | Mar 31, 2003 (113) |
| 3 | RIKENSNPRC | ss6312391 | Feb 20, 2003 (111) |
| 4 | KIDDLAB | ss6396276 | Feb 20, 2003 (111) |
| 5 | IMCJ-GDT | ss22886662 | Apr 05, 2004 (121) |
| 6 | PERLEGEN | ss23975064 | Sep 20, 2004 (123) |
| 7 | PERLEGEN | ss69120732 | May 16, 2007 (127) |
| 8 | ILLUMINA | ss74897004 | Dec 06, 2007 (129) |
| 9 | KRIBB_YJKIM | ss80753382 | Dec 15, 2007 (130) |
| 10 | ILLUMINA | ss154376947 | Dec 01, 2009 (131) |
| 11 | ILLUMINA | ss159552805 | Dec 01, 2009 (131) |
| 12 | ILLUMINA | ss160800710 | Dec 01, 2009 (131) |
| 13 | ILLUMINA | ss174079322 | Jul 04, 2010 (132) |
| 14 | 1000GENOMES | ss242617061 | Jul 15, 2010 (132) |
| 15 | OMICIA | ss244239102 | May 27, 2010 (132) |
| 16 | ILLUMINA | ss244306137 | Jul 04, 2010 (132) |
| 17 | GMI | ss281549272 | May 04, 2012 (137) |
| 18 | ILLUMINA | ss410800718 | Sep 17, 2011 (135) |
| 19 | PAGE_STUDY | ss469414445 | May 04, 2012 (137) |
| 20 | PAGE_STUDY | ss469415096 | May 04, 2012 (137) |
| 21 | ILLUMINA | ss481326066 | May 04, 2012 (137) |
| 22 | ILLUMINA | ss481351311 | May 04, 2012 (137) |
| 23 | ILLUMINA | ss481756757 | May 04, 2012 (137) |
| 24 | ILLUMINA | ss482332407 | Sep 08, 2015 (146) |
| 25 | ILLUMINA | ss482974587 | May 04, 2012 (137) |
| 26 | ILLUMINA | ss485458172 | May 04, 2012 (137) |
| 27 | 1000GENOMES | ss491051741 | May 04, 2012 (137) |
| 28 | EXOME_CHIP | ss491473855 | May 04, 2012 (137) |
| 29 | ILLUMINA | ss534381777 | Sep 08, 2015 (146) |
| 30 | SSMP | ss658991113 | Apr 25, 2013 (138) |
| 31 | ILLUMINA | ss779305026 | Sep 08, 2015 (146) |
| 32 | ILLUMINA | ss780692822 | Sep 08, 2015 (146) |
| 33 | ILLUMINA | ss781561293 | Sep 08, 2015 (146) |
| 34 | ILLUMINA | ss783174562 | Sep 08, 2015 (146) |
| 35 | ILLUMINA | ss783366651 | Sep 08, 2015 (146) |
| 36 | ILLUMINA | ss832434140 | Sep 08, 2015 (146) |
| 37 | ILLUMINA | ss833063977 | Jul 13, 2019 (153) |
| 38 | ILLUMINA | ss834772315 | Sep 08, 2015 (146) |
| 39 | JMKIDD_LAB | ss1067537773 | Aug 21, 2014 (142) |
| 40 | JMKIDD_LAB | ss1078774599 | Aug 21, 2014 (142) |
| 41 | 1000GENOMES | ss1346661620 | Aug 21, 2014 (142) |
| 42 | HAMMER_LAB | ss1397645703 | Sep 08, 2015 (146) |
| 43 | EVA_UK10K_ALSPAC | ss1629458722 | Apr 01, 2015 (144) |
| 44 | EVA_UK10K_TWINSUK | ss1672452755 | Apr 01, 2015 (144) |
| 45 | EVA_EXAC | ss1691113697 | Apr 01, 2015 (144) |
| 46 | EVA_SVP | ss1713358466 | Apr 01, 2015 (144) |
| 47 | ILLUMINA | ss1752046726 | Sep 08, 2015 (146) |
| 48 | ILLUMINA | ss1752046727 | Sep 08, 2015 (146) |
| 49 | ILLUMINA | ss1917878964 | Feb 12, 2016 (147) |
| 50 | ILLUMINA | ss1946350057 | Feb 12, 2016 (147) |
| 51 | ILLUMINA | ss1946350058 | Feb 12, 2016 (147) |
| 52 | ILLUMINA | ss1959466682 | Feb 12, 2016 (147) |
| 53 | ILLUMINA | ss1959466683 | Feb 12, 2016 (147) |
| 54 | AMU | ss1966651573 | Feb 12, 2016 (147) |
| 55 | ILLUMINA | ss2095039621 | Dec 20, 2016 (150) |
| 56 | HUMAN_LONGEVITY | ss2193238241 | Dec 20, 2016 (150) |
| 57 | SYSTEMSBIOZJU | ss2628189375 | Nov 08, 2017 (151) |
| 58 | ILLUMINA | ss2633009295 | Nov 08, 2017 (151) |
| 59 | ILLUMINA | ss2633009296 | Nov 08, 2017 (151) |
| 60 | ILLUMINA | ss2633009297 | Nov 08, 2017 (151) |
| 61 | ILLUMINA | ss2633009298 | Nov 08, 2017 (151) |
| 62 | ILLUMINA | ss2635040720 | Nov 08, 2017 (151) |
| 63 | GRF | ss2700123345 | Nov 08, 2017 (151) |
| 64 | ILLUMINA | ss2710770967 | Nov 08, 2017 (151) |
| 65 | GNOMAD | ss2740141605 | Nov 08, 2017 (151) |
| 66 | GNOMAD | ss2748963066 | Nov 08, 2017 (151) |
| 67 | GNOMAD | ss2915247802 | Nov 08, 2017 (151) |
| 68 | AFFY | ss2984991288 | Nov 08, 2017 (151) |
| 69 | AFFY | ss2985627283 | Nov 08, 2017 (151) |
| 70 | ILLUMINA | ss3021466933 | Nov 08, 2017 (151) |
| 71 | ILLUMINA | ss3021466934 | Nov 08, 2017 (151) |
| 72 | ILLUMINA | ss3625634614 | Oct 12, 2018 (152) |
| 73 | ILLUMINA | ss3625634615 | Oct 12, 2018 (152) |
| 74 | ILLUMINA | ss3626970253 | Oct 12, 2018 (152) |
| 75 | ILLUMINA | ss3626970254 | Oct 12, 2018 (152) |
| 76 | ILLUMINA | ss3631015681 | Oct 12, 2018 (152) |
| 77 | ILLUMINA | ss3633034452 | Oct 12, 2018 (152) |
| 78 | ILLUMINA | ss3633735970 | Oct 12, 2018 (152) |
| 79 | ILLUMINA | ss3634524054 | Oct 12, 2018 (152) |
| 80 | ILLUMINA | ss3634524055 | Oct 12, 2018 (152) |
| 81 | ILLUMINA | ss3635426434 | Oct 12, 2018 (152) |
| 82 | ILLUMINA | ss3636209904 | Oct 12, 2018 (152) |
| 83 | ILLUMINA | ss3637177442 | Oct 12, 2018 (152) |
| 84 | ILLUMINA | ss3637987300 | Oct 12, 2018 (152) |
| 85 | ILLUMINA | ss3640231387 | Oct 12, 2018 (152) |
| 86 | ILLUMINA | ss3640231388 | Oct 12, 2018 (152) |
| 87 | ILLUMINA | ss3642978887 | Oct 12, 2018 (152) |
| 88 | ILLUMINA | ss3644603064 | Oct 12, 2018 (152) |
| 89 | ILLUMINA | ss3644603065 | Oct 12, 2018 (152) |
| 90 | ILLUMINA | ss3651849275 | Oct 12, 2018 (152) |
| 91 | ILLUMINA | ss3651849276 | Oct 12, 2018 (152) |
| 92 | ILLUMINA | ss3651849277 | Oct 12, 2018 (152) |
| 93 | ILLUMINA | ss3653761183 | Oct 12, 2018 (152) |
| 94 | ILLUMINA | ss3725358006 | Jul 13, 2019 (153) |
| 95 | ILLUMINA | ss3744105312 | Jul 13, 2019 (153) |
| 96 | ILLUMINA | ss3744401172 | Jul 13, 2019 (153) |
| 97 | ILLUMINA | ss3744824869 | Jul 13, 2019 (153) |
| 98 | ILLUMINA | ss3744824870 | Jul 13, 2019 (153) |
| 99 | EVA | ss3750971950 | Jul 13, 2019 (153) |
| 100 | PAGE_CC | ss3771717819 | Jul 13, 2019 (153) |
| 101 | ILLUMINA | ss3772324072 | Jul 13, 2019 (153) |
| 102 | ILLUMINA | ss3772324073 | Jul 13, 2019 (153) |
| 103 | KHV_HUMAN_GENOMES | ss3816303952 | Jul 13, 2019 (153) |
| 104 | SGDP_PRJ | ss3879124379 | Apr 27, 2020 (154) |
| 105 | KRGDB | ss3927868593 | Apr 27, 2020 (154) |
| 106 | KOGIC | ss3972739586 | Apr 27, 2020 (154) |
| 107 | EVA | ss3984673321 | Apr 25, 2021 (155) |
| 108 | EVA | ss3984673322 | Apr 25, 2021 (155) |
| 109 | EVA | ss3985615205 | Apr 25, 2021 (155) |
| 110 | EVA | ss3986586517 | Apr 25, 2021 (155) |
| 111 | EVA | ss4017611004 | Apr 25, 2021 (155) |
| 112 | TOPMED | ss4932981090 | Apr 25, 2021 (155) |
| 113 | TOMMO_GENOMICS | ss5208191351 | Apr 25, 2021 (155) |
| 114 | EVA | ss5236853447 | Apr 25, 2021 (155) |
| 115 | EVA | ss5236909302 | Apr 25, 2021 (155) |
| 116 | EVA | ss5237518643 | Apr 25, 2021 (155) |
| 117 | 1000G_HIGH_COVERAGE | ss5292253743 | Oct 16, 2022 (156) |
| 118 | TRAN_CS_UWATERLOO | ss5314436755 | Oct 16, 2022 (156) |
| 119 | EVA | ss5315649603 | Oct 16, 2022 (156) |
| 120 | EVA | ss5408264946 | Oct 16, 2022 (156) |
| 121 | HUGCELL_USP | ss5486855046 | Oct 16, 2022 (156) |
| 122 | 1000G_HIGH_COVERAGE | ss5590490158 | Oct 16, 2022 (156) |
| 123 | SANFORD_IMAGENETICS | ss5624312353 | Oct 16, 2022 (156) |
| 124 | SANFORD_IMAGENETICS | ss5653967699 | Oct 16, 2022 (156) |
| 125 | TOMMO_GENOMICS | ss5758523496 | Oct 16, 2022 (156) |
| 126 | EVA | ss5799403901 | Oct 16, 2022 (156) |
| 127 | YY_MCH | ss5813650036 | Oct 16, 2022 (156) |
| 128 | EVA | ss5847683875 | Oct 16, 2022 (156) |
| 129 | EVA | ss5906045247 | Oct 16, 2022 (156) |
| 130 | EVA | ss5945375168 | Oct 16, 2022 (156) |
| 131 | EVA | ss5979404231 | Oct 16, 2022 (156) |
| 132 | SNP-ZJ | ss5981325931 | Oct 16, 2022 (156) |
| 133 | 1000Genomes | NC_000012.11 - 112241766 | Oct 12, 2018 (152) |
| 134 | 1000Genomes_30x | NC_000012.12 - 111803962 | Oct 16, 2022 (156) |
| 135 | The Avon Longitudinal Study of Parents and Children | NC_000012.11 - 112241766 | Oct 12, 2018 (152) |
| 136 | Genome-wide autozygosity in Daghestan | NC_000012.10 - 110726149 | Apr 27, 2020 (154) |
| 137 | ExAC | NC_000012.11 - 112241766 | Oct 12, 2018 (152) |
| 138 | gnomAD - Genomes | NC_000012.12 - 111803962 | Apr 25, 2021 (155) |
| 139 | gnomAD - Exomes | NC_000012.11 - 112241766 | Jul 13, 2019 (153) |
| 140 | HapMap | NC_000012.12 - 111803962 | Apr 27, 2020 (154) |
| 141 | KOREAN population from KRGDB | NC_000012.11 - 112241766 | Apr 27, 2020 (154) |
| 142 | Korean Genome Project | NC_000012.12 - 111803962 | Apr 27, 2020 (154) |
| 143 | The PAGE Study | NC_000012.12 - 111803962 | Jul 13, 2019 (153) |
| 144 | Ancient Sardinia genome-wide 1240k capture data generation and analysis | NC_000012.11 - 112241766 | Apr 25, 2021 (155) |
| 145 |
CNV burdens in cranial meningiomas
Submission ignored due to conflicting rows: |
- | Apr 25, 2021 (155) |
| 146 |
CNV burdens in cranial meningiomas
Submission ignored due to conflicting rows: |
- | Apr 25, 2021 (155) |
| 147 | SGDP_PRJ | NC_000012.11 - 112241766 | Apr 27, 2020 (154) |
| 148 | 8.3KJPN | NC_000012.11 - 112241766 | Apr 25, 2021 (155) |
| 149 | 14KJPN | NC_000012.12 - 111803962 | Oct 16, 2022 (156) |
| 150 | TopMed | NC_000012.12 - 111803962 | Apr 25, 2021 (155) |
| 151 | UK 10K study - Twins | NC_000012.11 - 112241766 | Oct 12, 2018 (152) |
| 152 | A Vietnamese Genetic Variation Database | NC_000012.11 - 112241766 | Jul 13, 2019 (153) |
| 153 | ALFA | NC_000012.12 - 111803962 | Apr 25, 2021 (155) |
| 154 | ClinVar | RCV000020058.7 | Oct 16, 2022 (156) |
| 155 | ClinVar | RCV000020059.5 | Apr 25, 2021 (155) |
| 156 | ClinVar | RCV000020060.5 | Apr 25, 2021 (155) |
| 157 | ClinVar | RCV000020061.5 | Apr 25, 2021 (155) |
| 158 | ClinVar | RCV000020062.5 | Apr 25, 2021 (155) |
| 159 | ClinVar | RCV001290000.2 | Apr 25, 2021 (155) |
| 160 | ClinVar | RCV001787815.1 | Oct 16, 2022 (156) |
Help
History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
| Associated ID | History Updated (Build) |
|---|---|
| rs2230021 | Jan 04, 2002 (102) |
| rs4134524 | Nov 14, 2002 (109) |
| rs4986830 | Apr 07, 2003 (113) |
| rs60823674 | May 26, 2008 (130) |
Added to this RefSNP Cluster:
| Submission IDs | Observation SPDI | Canonical SPDI | Source RSIDs |
|---|---|---|---|
| 116453, ss281549272, ss481326066, ss482974587, ss1397645703, ss1713358466, ss2635040720, ss3642978887 | NC_000012.10:110726148:G:A | NC_000012.12:111803961:G:A | (self) |
| 59473220, 33030752, 1428501, 9380044, 35045987, 841132, 31141359, 66160658, 33030752, 7328758, ss242617061, ss481351311, ss481756757, ss482332407, ss485458172, ss491051741, ss491473855, ss534381777, ss658991113, ss779305026, ss780692822, ss781561293, ss783174562, ss783366651, ss832434140, ss833063977, ss834772315, ss1067537773, ss1078774599, ss1346661620, ss1629458722, ss1672452755, ss1691113697, ss1752046726, ss1752046727, ss1917878964, ss1946350057, ss1946350058, ss1959466682, ss1959466683, ss1966651573, ss2095039621, ss2628189375, ss2633009295, ss2633009296, ss2633009297, ss2633009298, ss2700123345, ss2710770967, ss2740141605, ss2748963066, ss2915247802, ss2984991288, ss2985627283, ss3021466933, ss3021466934, ss3625634614, ss3625634615, ss3626970253, ss3626970254, ss3631015681, ss3633034452, ss3633735970, ss3634524054, ss3634524055, ss3635426434, ss3636209904, ss3637177442, ss3637987300, ss3640231387, ss3640231388, ss3644603064, ss3644603065, ss3651849275, ss3651849276, ss3651849277, ss3653761183, ss3744105312, ss3744401172, ss3744824869, ss3744824870, ss3750971950, ss3772324072, ss3772324073, ss3879124379, ss3927868593, ss3984673321, ss3984673322, ss3985615205, ss3986586517, ss4017611004, ss5208191351, ss5237518643, ss5315649603, ss5408264946, ss5624312353, ss5653967699, ss5799403901, ss5847683875, ss5945375168, ss5979404231 | NC_000012.11:112241765:G:A | NC_000012.12:111803961:G:A | (self) |
| RCV000020058.7, RCV000020059.5, RCV000020060.5, RCV000020061.5, RCV000020062.5, RCV001290000.2, RCV001787815.1, 78016093, 419512545, 905641, 29117587, 939288, 92360600, 148526747, 604374811, ss244239102, ss2193238241, ss3725358006, ss3771717819, ss3816303952, ss3972739586, ss4932981090, ss5236853447, ss5236909302, ss5292253743, ss5314436755, ss5486855046, ss5590490158, ss5758523496, ss5813650036, ss5906045247, ss5981325931 | NC_000012.12:111803961:G:A | NC_000012.12:111803961:G:A | (self) |
| ss676, ss5586234, ss6312391, ss6396276, ss22886662, ss23975064, ss69120732, ss74897004, ss80753382, ss154376947, ss159552805, ss160800710, ss174079322, ss244306137, ss410800718, ss469414445, ss469415096 | NT_009775.17:2818295:G:A | NC_000012.12:111803961:G:A | (self) |
Help
Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
293
citations for rs671
| PMID | Title | Author | Year | Journal |
|---|---|---|---|---|
| 2987944 | Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. | Hsu LC et al. | 1985 | Proceedings of the National Academy of Sciences of the United States of America |
| 4065146 | Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. | Hempel J et al. | 1985 | European journal of biochemistry |
| 6582480 | Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. | Yoshida A et al. | 1984 | Proceedings of the National Academy of Sciences of the United States of America |
| 7180842 | Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity. | Impraim C et al. | 1982 | American journal of human genetics |
| 7593603 | The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. | Xiao Q et al. | 1995 | The Journal of clinical investigation |
| 8903321 | The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. | Xiao Q et al. | 1996 | The Journal of clinical investigation |
| 10627091 | Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. | Wall TL et al. | 2000 | Journal of studies on alcohol |
| 10780266 | Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. | Peng GS et al. | 1999 | Pharmacogenetics |
| 15654505 | Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. | Liu Y et al. | 2005 | Journal of human genetics |
| 16046871 | Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. | Yokoyama M et al. | 2005 | Alcoholism, clinical and experimental research |
| 16440063 | Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. | Li Y et al. | 2006 | The Journal of clinical investigation |
| 16595073 | Functional nsSNPs from carcinogenesis-related genes expressed in breast tissue: potential breast cancer risk alleles and their distribution across human populations. | Savas S et al. | 2006 | Human genomics |
| 17885622 | Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. | Peng GS et al. | 2007 | Pharmacogenetics and genomics |
| 18056758 | Major genetic components underlying alcoholism in Korean population. | Kim DJ et al. | 2008 | Human molecular genetics |
| 18317873 | Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs). | Nose J et al. | 2008 | Journal of human genetics |
| 18331377 | Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. | Kuo PH et al. | 2008 | Alcoholism, clinical and experimental research |
| 18996923 | Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | 2009 | Human molecular genetics |
| 19041386 | Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. | Boes E et al. | 2009 | Experimental gerontology |
| 19262484 | Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. | Tsuchihashi-Makaya M et al. | 2009 | Hypertension research |
| 19430479 | Genome-wide association study of blood pressure and hypertension. | Levy D et al. | 2009 | Nature genetics |
| 19641380 | Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. | Park JW et al. | 2009 | Experimental & molecular medicine |
| 19698717 | Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. | Cui R et al. | 2009 | Gastroenterology |
| 19706845 | A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. | Yang H et al. | 2009 | Cancer epidemiology, biomarkers & prevention |
| 19826048 | Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. | Akbari MR et al. | 2009 | Cancer research |
| 20010786 | Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. | Ding JH et al. | 2010 | Journal of human genetics |
| 20093384 | Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population. | Park JY et al. | 2010 | Carcinogenesis |
| 20100738 | Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. | Ji F et al. | 2010 | Carcinogenesis |
| 20417517 | The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. | Guo YJ et al. | 2010 | Atherosclerosis |
| 20505153 | A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | 2010 | Journal of the National Cancer Institute |
| 20518787 | Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population. | Oze I et al. | 2010 | Cancer science |
| 20585100 | Genome-wide association studies of cancer. | Stadler ZK et al. | 2010 | Journal of clinical oncology |
| 20616999 | Usefulness of Mendelian randomization in observational epidemiology. | Bochud M et al. | 2010 | International journal of environmental research and public health |
| 20729852 | A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. | Abnet CC et al. | 2010 | Nature genetics |
| 20833657 | Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. | Tanaka F et al. | 2010 | Gut |
| 20981351 | Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study. | Sugimoto K et al. | 2010 | International journal of hypertension |
| 21083667 | Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. | Liu J et al. | 2011 | Alcoholism, clinical and experimental research |
| 21315679 | Green tea consumption, inflammation and the risk of primary hepatocellular carcinoma in a Chinese population. | Li Y et al. | 2011 | Cancer epidemiology |
| 21338875 | Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ et al. | 2011 | Neuron |
| 21351086 | Shortened telomeres in individuals with abuse in alcohol consumption. | Pavanello S et al. | 2011 | International journal of cancer |
| 21367945 | Genome-wide association studies of alcohol intake--a promising cocktail? | Agrawal A et al. | 2011 | The American journal of clinical nutrition |
| 21372407 | Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. | Takeuchi F et al. | 2011 | Circulation journal |
| 21437268 | A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. | McKay JD et al. | 2011 | PLoS genetics |
| 21455501 | Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature. | Li M et al. | 2011 | PloS one |
| 21467728 | Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. | Wakai K et al. | 2011 | Journal of epidemiology |
| 21572416 | Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. | Kato N et al. | 2011 | Nature genetics |
| 21576033 | ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population. | Ji YB et al. | 2011 | Oral oncology |
| 21900886 | Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. | Ray LA et al. | 2012 | Neuropsychopharmacology |
| 21917409 | Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. | Pavanello S et al. | 2012 | Alcohol (Fayetteville, N.Y.) |
| 21926110 | Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa. | Bye H et al. | 2011 | Carcinogenesis |
| 21946912 | Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. | Matsuo K et al. | 2012 | European journal of cancer prevention |
| 21971053 | Genome-wide association study of coronary artery disease in the Japanese. | Takeuchi F et al. | 2012 | European journal of human genetics |
| 22004425 | Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. | Tomoda T et al. | 2012 | Journal of gastroenterology and hepatology |
| 22004471 | Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. | Frank J et al. | 2012 | Addiction biology |
| 22010049 | Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations. | Middelberg RP et al. | 2012 | Human molecular genetics |
| 22102315 | Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. | Li D et al. | 2012 | Human genetics |
| 22171074 | A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. | Tan A et al. | 2012 | Human molecular genetics |
| 22301922 | Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A et al. | 2012 | The American journal of clinical nutrition |
| 22507220 | Epidemiologic differences in esophageal cancer between Asian and Western populations. | Zhang HZ et al. | 2012 | Chinese journal of cancer |
| 22508505 | Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. | Hoshi H et al. | 2012 | Journal of bone and mineral research |
| 22551939 | Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population. | Wang Y et al. | 2013 | Journal of human hypertension |
| 22560290 | A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain. | Celorrio D et al. | 2012 | Alcohol (Fayetteville, N.Y.) |
| 22640768 | The genetic basis of addictive disorders. | Ducci F et al. | 2012 | The Psychiatric clinics of North America |
| 22674868 | Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China. | Yuan H et al. | 2013 | Molecular carcinogenesis |
| 22675424 | ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies. | Xue Y et al. | 2012 | PloS one |
| 22806211 | The genetics of addiction-a translational perspective. | Agrawal A et al. | 2012 | Translational psychiatry |
| 22839215 | Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. | Chang YC et al. | 2012 | BMC cardiovascular disorders |
| 22865593 | Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. | Bye H et al. | 2012 | Carcinogenesis |
| 22930414 | Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. | Wu M et al. | 2013 | International journal of cancer |
| 23072573 | Multiplex allele-specific amplification from whole blood for detecting multiple polymorphisms simultaneously. | Zhu J et al. | 2013 | Genetic testing and molecular biomarkers |
| 23088731 | Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. | Chung CS et al. | 2014 | Diseases of the esophagus |
| 23243119 | Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? | Au Yeung SL et al. | 2013 | International journal of epidemiology |
| 23364009 | Common variants at 12q24 are associated with drinking behavior in Han Chinese. | Yang X et al. | 2013 | The American journal of clinical nutrition |
| 23430454 | Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population. | Gao Y et al. | 2013 | Human genetics |
| 23455379 | The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. | Matsuo K et al. | 2013 | Carcinogenesis |
| 23629646 | Epidemiology of esophageal cancer in Japan and China. | Lin Y et al. | 2013 | Journal of epidemiology |
| 23685282 | Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis. | Han H et al. | 2013 | Gene |
| 23697560 | ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression. | Wang Q et al. | 2013 | DNA and cell biology |
| 23969552 | Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes. | Yokoyama A et al. | 2014 | Alcohol and alcoholism (Oxford, Oxfordshire) |
| 24037726 | Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. | Hira A et al. | 2013 | Blood |
| 24274136 | Biobanking across the phenome - at the center of chronic disease research. | Imboden M et al. | 2013 | BMC public health |
| 24277619 | ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. | Quillen EE et al. | 2014 | American journal of medical genetics. Part B, Neuropsychiatric genetics |
| 24633362 | ALDH2 and ADH1 genetic polymorphisms may contribute to the risk of gastric cancer: a meta-analysis. | Wang HL et al. | 2014 | PloS one |
| 24652602 | Alcohol consumption and lifetime change in cognitive ability: a gene × environment interaction study. | Ritchie SJ et al. | 2014 | Age (Dordrecht, Netherlands) |
| 24861553 | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. | Wen W et al. | 2014 | Human molecular genetics |
| 24968322 | Single nucleotide polymorphisms associated with colorectal cancer susceptibility and loss of heterozygosity in a Taiwanese population. | Yang CY et al. | 2014 | PloS one |
| 25045619 | The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH et al. | 2014 | Current behavioral neuroscience reports |
| 25047496 | Synergistic association between two alcohol metabolism relevant genes and coronary artery disease among Chinese hypertensive patients. | Wang Y et al. | 2014 | PloS one |
| 25133033 | Epidemiological studies of esophageal cancer in the era of genome-wide association studies. | Wang AH et al. | 2014 | World journal of gastrointestinal pathophysiology |
| 25313998 | The ALDH2 rs671 polymorphism affects post-stroke epilepsy susceptibility and plasma 4-HNE levels. | Yang H et al. | 2014 | PloS one |
| 25403981 | Meta-analysis of association between ALDH2 rs671 polymorphism and essential hypertension in Asian populations. | Zhang SY et al. | 2015 | Herz |
| 25411394 | Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms as indicator of mental disorders in Japanese employees. | Yoshimasu K et al. | 2015 | Alcohol and alcoholism (Oxford, Oxfordshire) |
| 25427900 | Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ et al. | 2015 | Advances in experimental medicine and biology |
| 25543168 | Genetic alcohol sensitivity regulated by ALDH2 and ADH1B polymorphisms is strongly associated with depression and anxiety in Japanese employees. | Yoshimasu K et al. | 2015 | Drug and alcohol dependence |
| 25573768 | Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan. | Ting TT et al. | 2015 | Drug and alcohol dependence |
| 25636114 | [Advance in research on the association of ALDH2 gene polymorphisms with cancer susceptibility in drinkers]. | Chen C et al. | 2015 | Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics |
| 25680115 | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | 2015 | PloS one |
| 25803854 | Genotyping on ALDH2: comparison of four different technologies. | Zhang L et al. | 2015 | PloS one |
| 26125444 | Family history of cancer and the risk of squamous cell carcinoma of oesophagus: a case-control study in Kashmir, India. | Bhat GA et al. | 2015 | British journal of cancer |
| 26130061 | Aldehyde dehydrogenase 2 genetic variations may increase susceptibility to Parkinson's disease in Han Chinese population. | Zhang X et al. | 2015 | Neurobiology of aging |
| 26174136 | Three missense variants of metabolic syndrome-related genes are associated with alpha-1 antitrypsin levels. | Setoh K et al. | 2015 | Nature communications |
| 26284938 | Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men. | Yokoyama A et al. | 2015 | PloS one |
| 26356841 | Alcohol Use and Gamma-Glutamyltransferase Using a Mendelian Randomization Design in the Guangzhou Biobank Cohort Study. | Xu L et al. | 2015 | PloS one |
| 26364564 | Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. | Taylor AE et al. | 2015 | Scientific reports |
| 26542604 | Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes and Alcoholic Ketosis Are Associated with the Serum Uric Acid Level in Japanese Alcoholic Men. | Yokoyama A et al. | 2016 | Alcohol and alcoholism (Oxford, Oxfordshire) |
| 26599441 | Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry. | Idewaki Y et al. | 2015 | PloS one |
| 26687910 | Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study. | Cho Y et al. | 2015 | Scientific reports |
| 26770579 | Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. | Jia X et al. | 2015 | International journal of clinical and experimental medicine |
| 26785701 | Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. | Wen W et al. | 2016 | Scientific reports |
| 26825972 | Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. | Hashimoto M et al. | 2016 | Environmental health and preventive medicine |
| 26827895 | Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. | Liu J et al. | 2016 | Cancer epidemiology, biomarkers & prevention |
| 26833210 | Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population. | Kim YK et al. | 2016 | Cardiovascular diabetology |
| 26847647 | Experimental Biology for the Identification of Causal Pathways in Atherosclerosis. | Guo Y et al. | 2016 | Cardiovascular drugs and therapy |
| 26848030 | Effects of Obesity Related Genetic Variations on Visceral and Subcutaneous Fat Distribution in a Chinese Population. | Wang T et al. | 2016 | Scientific reports |
| 26891264 | No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study. | Kim J et al. | 2016 | PloS one |
| 26954674 | Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS). | Xing F et al. | 2016 | PloS one |
| 26992901 | Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction. | Masaoka H et al. | 2016 | Carcinogenesis |
| 26995653 | Impacts of common variants in ALDH2 on coronary artery disease patients. | Zhao J et al. | 2016 | Gene |
| 27038040 | ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. | Kagemoto K et al. | 2016 | Cancer medicine |
| 27118149 | Risk and predictors of hepatocellular carcinoma for chronic hepatitis B patients with newly developed cirrhosis. | Chien J et al. | 2016 | Journal of gastroenterology and hepatology |
| 27181629 | Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus. | Sakiyama M et al. | 2016 | Scientific reports |
| 27191745 | Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque. | Pan C et al. | 2016 | Oncotarget |
| 27294413 | Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016. | Srivastava AK et al. | 2016 | Human genomics |
| 27437086 | Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences. | Eom SY et al. | 2016 | Toxicological research |
| 27453488 | Aldehyde dehydrogenase 2 is associated with cognitive functions in patients with Parkinson's disease. | Yu RL et al. | 2016 | Scientific reports |
| 27588484 | Gene-gene interactions in gastrointestinal cancer susceptibility. | Kim J et al. | 2016 | Oncotarget |
| 27827401 | Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study. | Svensson T et al. | 2016 | Scientific reports |
| 27927211 | Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese. | Nakano Y et al. | 2016 | Journal of biomedical science |
| 27986911 | Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation. | Masaoka H et al. | 2017 | Nicotine & tobacco research |
| 27991683 | Platelet Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. | Yokoyama A et al. | 2017 | Alcoholism, clinical and experimental research |
| 28052001 | Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population. | Zhang C et al. | 2017 | Oncotarget |
| 28158543 | Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites. | Roy Choudhury A et al. | 2017 | Bioinformatics (Oxford, England) |
| 28208752 | Meta-Analysis on the Association of ALDH2 Polymorphisms and Type 2 Diabetic Mellitus, Diabetic Retinopathy. | Li GY et al. | 2017 | International journal of environmental research and public health |
| 28212515 | Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population. | Masaoka H et al. | 2017 | Drug and alcohol dependence |
| 28212632 | Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population. | Eom SY et al. | 2017 | Environmental health |
| 28348376 | A missense single nucleotide polymorphism in the ALDH2 gene, rs671, is associated with hip fracture. | Takeshima K et al. | 2017 | Scientific reports |
| 28371326 | Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study. | Zhu Y et al. | 2017 | Journal of cellular and molecular medicine |
| 28443204 | Association of genotypes of rs671 withinALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. | Zhang LQ et al. | 2017 | Cancer biology & medicine |
| 28464297 | Correlations of ALDH2 rs671 and C12orf30 rs4767364 polymorphisms with increased risk and prognosis of esophageal squamous cell carcinoma in the Kazak and Han populations in Xinjiang province. | Liu P et al. | 2018 | Journal of clinical laboratory analysis |
| 28471244 | ALDH2*2 and peer drinking in East Asian college students. | O'Shea T et al. | 2017 | The American journal of drug and alcohol abuse |
| 28472173 | Positive association between ALDH2 rs671 polymorphism and essential hypertension: A case-control study and meta-analysis. | Wu Y et al. | 2017 | PloS one |
| 28485404 | Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | 2017 | Molecular psychiatry |
| 28540979 | Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea. | Shin MJ et al. | 2017 | Yonsei medical journal |
| 28562329 | Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies. | Yamada Y et al. | 2017 | Oncotarget |
| 28566767 | Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk. | Sakiyama M et al. | 2017 | Scientific reports |
| 28594837 | Genetic variants in ALDH1B1 and alcohol dependence risk in a British and Irish population: A bioinformatic and genetic study. | Way MJ et al. | 2017 | PloS one |
| 28613083 | The ALDH2 gene rs671 polymorphism is not associated with essential hypertension. | Li ZM et al. | 2017 | Clinical and experimental hypertension (New York, N.Y. |
| 28728635 | Gene-by-Environment Interactions on Alcohol Use Among Asian American College Freshmen. | Luk JW et al. | 2017 | Journal of studies on alcohol and drugs |
| 28778129 | ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study. | Lee SY et al. | 2018 | The Australian and New Zealand journal of psychiatry |
| 28805974 | Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. | Katsarou MS et al. | 2017 | Pharmacology research & perspectives |
| 28876462 | The Causal Role of Alcohol Use in Adolescent Externalizing and Internalizing Problems: A Mendelian Randomization Study. | Chao M et al. | 2017 | Alcoholism, clinical and experimental research |
| 28894224 | Associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms, lifestyles and hypertension risk in Chinese Han people. | Ma C et al. | 2017 | Scientific reports |
| 29063269 | Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. | Yokoyama A et al. | 2018 | Journal of gastroenterology |
| 29124443 | Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population. | Yasukochi Y et al. | 2018 | Molecular genetics and genomics |
| 29166882 | Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India. | Ghosh S et al. | 2017 | BMC cancer |
| 29176272 | Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men. | Sasakabe T et al. | 2018 | Journal of epidemiology |
| 29223883 | Analysis of mainland Japanese and Okinawan Japanese populations using the precision ID Ancestry Panel. | Nakanishi H et al. | 2018 | Forensic science international. Genetics |
| 29247577 | Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium. | Ugai T et al. | 2018 | Cancer science |
| 29254255 | Association between ALDH2 rs671 G>A polymorphism and gastric cancer susceptibility in Eastern Asia. | Jiang Y et al. | 2017 | Oncotarget |
| 29286190 | Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer. | Avinçsal MO et al. | 2018 | Head & neck |
| 29323248 | Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans. | Cho Y et al. | 2018 | Scientific reports |
| 29386454 | [Importance of an Aldehyde Dehydrogenase 2 Polymorphism in Preventive Medicine]. | Matsumoto A et al. | 2018 | Nihon eiseigaku zasshi. Japanese journal of hygiene |
| 29408531 | The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study. | Zhang D et al. | 2018 | Gene |
| 29426835 | Transcriptome analysis and prognosis of ALDH isoforms in human cancer. | Chang PM et al. | 2018 | Scientific reports |
| 29460428 | Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. | Gelernter J et al. | 2018 | Alcoholism, clinical and experimental research |
| 29616362 | Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer: a replication and mediation analysis. | Ishioka K et al. | 2018 | Gastric cancer |
| 29623947 | Genetic Polymorphisms of the Mitochondrial Aldehyde Dehydrogenase ALDH2 Gene in a Large Ethnic Hakka Population in Southern China. | Zhong Z et al. | 2018 | Medical science monitor |
| 29707772 | Association of low-activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population-based cohort study. | Yu C et al. | 2018 | International journal of cancer |
| 29722023 | Discovery of 4 exonic and 1 intergenic novel susceptibility loci for leprosy. | Wang Z et al. | 2018 | Clinical genetics |
| 29742731 | Associations of common variants at ALDH2 gene and the risk of stroke in patients with coronary artery diseases undergoing percutaneous coronary intervention. | You L et al. | 2018 | Medicine |
| 29765251 | Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. | Ye X et al. | 2018 | Cancer management and research |
| 29779728 | Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. | Chang B et al. | 2018 | The American journal of the medical sciences |
| 29942042 | A decade in psychiatric GWAS research. | Horwitz T et al. | 2019 | Molecular psychiatry |
| 29953918 | Identification of three novel loci of ALDH2 Gene for Serum Folate levels in a Male Chinese Population by Genome-Wide Association Study. | Deng C et al. | 2018 | Gene |
| 29960587 | Interactions between ALDH2 rs671 polymorphism and lifestyle behaviors on coronary artery disease risk in a Chinese Han population with dyslipidemia: A guide to targeted heart health management. | Huang L et al. | 2018 | Environmental health and preventive medicine |
| 30123371 | Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout. | Zhu W et al. | 2018 | The open rheumatology journal |
| 30166580 | Genetic polymorphisms of ALDH2 are associated with lumbar disc herniation in a Chinese Han population. | Dong Q et al. | 2018 | Scientific reports |
| 30173282 | Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma. | Urabe Y et al. | 2019 | Esophagus |
| 30182779 | Genetic susceptibility to cerebrovascular disease: A systematic review. | Griessenauer CJ et al. | 2018 | Journal of cerebral blood flow and metabolism |
| 30202044 | Gastric cancer may share genetic predisposition with esophageal squamous cell carcinoma in Chinese populations. | Yao L et al. | 2018 | Journal of human genetics |
| 30326548 | Alcohol consumption and diabetes risk in a Chinese population: a Mendelian randomization analysis. | Peng M et al. | 2019 | Addiction (Abingdon, England) |
| 30334266 | ALDH2 Polymorphism rs671, but Not ADH1B Polymorphism rs1229984, Increases Risk for Hypo-HDL-Cholesterolemia in a/a Carriers Compared to the G/G Carriers. | Imatoh T et al. | 2018 | Lipids |
| 30374405 | eLD: entropy-based linkage disequilibrium index between multiallelic sites. | Okada Y et al. | 2018 | Human genome variation |
| 30375985 | Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. | Zhong S et al. | 2019 | The Journal of clinical investigation |
| 30399428 | Genome-wide association and gene-environment interaction study identifies variants in ALDH2 associated with serum ferritin in a Chinese population. | Tao Y et al. | 2019 | Gene |
| 30629674 | Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women. | Yokoyama A et al. | 2019 | PloS one |
| 30639619 | Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk. | Suo C et al. | 2019 | Journal of thoracic oncology |
| 30718733 | The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits. | Moon S et al. | 2019 | Scientific reports |
| 30753320 | Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population. | Chen WC et al. | 2019 | Carcinogenesis |
| 30793520 | Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies. | Tian J et al. | 2019 | Cancer medicine |
| 30810208 | Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population. | Nishiyama T et al. | 2019 | Sleep |
| 30842089 | Alcohol-metabolizing Enzymes' Gene Polymorphisms and Susceptibility to Multiple Head and Neck Cancers. | Chien HT et al. | 2019 | Cancer prevention research (Philadelphia, Pa.) |
| 30846829 | ALDH2 rs671 polymorphism and the risk of heart failure with preserved ejection fraction (HFpEF) in patients with cardiovascular diseases. | Xia CL et al. | 2020 | Journal of human hypertension |
| 30921184 | Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis. | Zuo W et al. | 2019 | Medicine |
| 30955975 | Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China. | Millwood IY et al. | 2019 | Lancet (London, England) |
| 30984100 | Association Between Aldehyde dehydrogenase-2 Polymorphisms and Risk of Alzheimer's Disease and Parkinson's Disease: A Meta-Analysis Based on 5,315 Individuals. | Chen J et al. | 2019 | Frontiers in neurology |
| 31066241 | The functional ALDH2 polymorphism is associated with breast cancer risk: A pooled analysis from the Breast Cancer Association Consortium. | Ugai T et al. | 2019 | Molecular genetics & genomic medicine |
| 31114233 | Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects. | Tang W et al. | 2019 | OncoTargets and therapy |
| 31227586 | Relationship between alcohol use, blood pressure and hypertension: an association study and a Mendelian randomisation study. | Zhao PP et al. | 2019 | Journal of epidemiology and community health |
| 31289104 | Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout. | Kawamura Y et al. | 2019 | Annals of the rheumatic diseases |
| 31320941 | Identification of the 12q24 locus associated with fish intake frequency by genome-wide meta-analysis in Japanese populations. | Igarashi M et al. | 2019 | Genes & nutrition |
| 31338989 | Causal effect of alcohol consumption on hyperuricemia using a Mendelian randomization design. | Jee YH et al. | 2019 | International journal of rheumatic diseases |
| 31361523 | Acetaldehyde Dehydrogenase 2 rs671 Polymorphism Affects Hypertension Susceptibility and Lipid Profiles in a Chinese Population. | Han S et al. | 2019 | DNA and cell biology |
| 31366848 | [Development of Novel Genotyping Protocol and Its Application for Genotyping of Alcohol Metabolism-related Genes]. | Imai M et al. | 2019 | Yakugaku zasshi |
| 31368098 | The Bidirectional Effect of Defective ALDH2 Polymorphism and Disease Prevention. | Matsumoto A et al. | 2019 | Advances in experimental medicine and biology |
| 31428123 | Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations. | Simba H et al. | 2019 | Frontiers in genetics |
| 31516756 | Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies. | Tian J et al. | 2019 | Cancer biology & medicine |
| 31558841 | Functional variants in ADH1B and ALDH2 are non-additively associated with all-cause mortality in Japanese population. | Sakaue S et al. | 2020 | European journal of human genetics |
| 31591379 | Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | 2019 | Translational psychiatry |
| 31737110 | The Defective Allele of Aldehyde Dehydrogenase 2 Gene is Associated with Favorable Postoperative Prognosis in Hepatocellular Carcinoma. | Huang PH et al. | 2019 | Journal of Cancer |
| 31762247 | [Microanalysis of Acetaldehyde Dehydrogenase 2 Genotype Based on SNaPShot-FCA]. | Zeng SS et al. | 2019 | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition |
| 31831791 | Effect of ALDH2 on Sleep Disturbances in Patients with Parkinson's Disease. | Lin CY et al. | 2019 | Scientific reports |
| 31842750 | A phenomics-based approach for the detection and interpretation of shared genetic influences on 29 biochemical indices in southern Chinese men. | Hu Y et al. | 2019 | BMC genomics |
| 31845443 | Associations among liver disease, serum lipid profile, body mass index, ketonuria, meal skipping, and the alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese men with alcohol dependence. | Yokoyama A et al. | 2020 | Hepatology research |
| 31911793 | Risks of incident heart failure with preserved ejection fraction in Chinese patients hospitalized for cardiovascular diseases. | Zhang JX et al. | 2019 | Journal of geriatric cardiology |
| 31987047 | Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis. | Chen J et al. | 2020 | World journal of surgical oncology |
| 32005715 | Across-Site Differences in the Mechanism of Alcohol-Induced Digestive Tract Carcinogenesis: An Evaluation by Mediation Analysis. | Koyanagi YN et al. | 2020 | Cancer research |
| 32084087 | Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men. | Yokoyama A et al. | 2020 | Pharmacogenetics and genomics |
| 32107439 | Association of alcohol dehydrogenase and aldehyde dehydrogenase Polymorphism with Spontaneous Deep Intracerebral Haemorrhage in the Taiwan population. | Huang YH et al. | 2020 | Scientific reports |
| 32141245 | Effect Modification of Acetaldehyde Dehydrogenase 2 rs671 Polymorphism on the Association between Alcohol Intake and Blood Pressure: the Dong-gu Study. | Kim HY et al. | 2020 | Journal of Korean medical science |
| 32223781 | Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk. | Seol JE et al. | 2020 | Public health nutrition |
| 32300124 | Role of aldehyde dehydrogenases, alcohol dehydrogenase 1B genotype, alcohol consumption, and their combination in breast cancer in East-Asian women. | Park B et al. | 2020 | Scientific reports |
| 32309376 | ALDH2 rs671 polymorphisms and the risk of cerebral microbleeds in Chinese elderly: the Taizhou Imaging Study. | Zhu Z et al. | 2020 | Annals of translational medicine |
| 32350201 | ALDH2 Gene rs671 Polymorphism May Decrease the Risk of Essential Hypertension. | Mei XF et al. | 2020 | International heart journal |
| 32356421 | Association between ALDH2 Polymorphism and Gastric Cancer Risk in a Korean Population. | Choi CK et al. | 2020 | Journal of Korean medical science |
| 32446379 | Astaxanthin improves osteopenia caused by aldehyde-stress resulting from Aldh2 mutation due to impaired osteoblastogenesis. | Hoshi H et al. | 2020 | Biochemical and biophysical research communications |
| 32481290 | Association between ALDH2 rs671 polymorphism and risk of ischemic stroke: A protocol for systematic review and meta analysis. | Jiang Y et al. | 2020 | Medicine |
| 32514006 | Polygenic analysis of the effect of common and low-frequency genetic variants on serum uric acid levels in Korean individuals. | Cho SK et al. | 2020 | Scientific reports |
| 32572145 | Strong association between the 12q24 locus and sweet taste preference in the Japanese population revealed by genome-wide meta-analysis. | Kawafune K et al. | 2020 | Journal of human genetics |
| 32760424 | Association Between ALDH-2 rs671 and Essential Hypertension Risk or Blood Pressure Levels: A Systematic Review and Meta-Analysis. | Zheng Y et al. | 2020 | Frontiers in genetics |
| 32802164 | A multinational review: Oesophageal cancer in low to middle-income countries. | Hull R et al. | 2020 | Oncology letters |
| 32896553 | A critical assessment of the potential of pharmacological modulation of aldehyde dehydrogenases to treat the diseases of bone loss. | Mittal M et al. | 2020 | European journal of pharmacology |
| 33004991 | ALDH2 genotype modulates the association between alcohol consumption and AST/ALT ratio among middle-aged Japanese men: a genome-wide G × E interaction analysis. | Sutoh Y et al. | 2020 | Scientific reports |
| 33060820 | Alcohol consumption is associated with glaucoma severity regardless of ALDH2 polymorphism. | Han YS et al. | 2020 | Scientific reports |
| 33093602 | CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. | Chen IC et al. | 2020 | Scientific reports |
| 33170161 | Genetic test for the prescription of diets in support of physical activity. | Naureen Z et al. | 2020 | Acta bio-medica |
| 33170513 | Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis. | Joo Kang S et al. | 2021 | Alcoholism, clinical and experimental research |
| 33188956 | ALDH2 mutation promotes skeletal muscle atrophy in mice via accumulation of oxidative stress. | Kobayashi H et al. | 2021 | Bone |
| 33193720 | Alcohol Use and Depression: A Mendelian Randomization Study From China. | Zhu C et al. | 2020 | Frontiers in genetics |
| 33249700 | Risk factors for esophageal iodine-unstained lesions and changing trends among Japanese alcohol-dependent men (2003-2018). | Yokoyama A et al. | 2021 | Cancer science |
| 33276716 | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population: associations differ between the sexes. | Wang D et al. | 2020 | BMC cardiovascular disorders |
| 33283290 | Association Between the Aldehyde Dehydrogenase-2 rs671 G>A Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis in East Asians. | Du XY et al. | 2021 | Alcoholism, clinical and experimental research |
| 33421985 | Association between ALDH2 and ADH1B Polymorphisms and the Risk for Colorectal Cancer in Koreans. | Choi CK et al. | 2021 | Cancer research and treatment |
| 33512438 | Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency. | Mu A et al. | 2021 | Blood |
| 33551739 | Association Study of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Alzheimer Disease in the Taiwanese Population. | Wu YY et al. | 2021 | Frontiers in neuroscience |
| 33552962 | Risk Factors and Genetic Biomarkers of Multiple Primary Cancers in Esophageal Cancer Patients. | Yang PW et al. | 2020 | Frontiers in oncology |
| 33592568 | Generation of induced pluripotent stem cells FIRDIi001-A from a Taiwanese subject carrying ALDH2 pE487K mutation. | Lu HE et al. | 2021 | Stem cell research |
| 33651448 | Prospective study: Aldehyde dehydrogenase 2 gene is associated with cardio-cerebrovascular complications in type 2 diabetes patients. | He Q et al. | 2021 | Journal of diabetes investigation |
| 33740503 | Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver. | Zhong S et al. | 2021 | Redox biology |
| 33750341 | Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study. | Choi CK et al. | 2021 | BMC cancer |
| 33808974 | Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease. | Yu RL et al. | 2021 | Brain sciences |
| 33858492 | Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake. | Liu YR et al. | 2021 | Arthritis research & therapy |
| 33893496 | Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants. | Curtis D et al. | 2022 | Alcohol and alcoholism (Oxford, Oxfordshire) |
| 33974068 | ALDH2 rs671 Is Associated With Elevated FPG, Reduced Glucose Clearance and Hepatic Insulin Resistance in Japanese Men. | Takeno K et al. | 2021 | The Journal of clinical endocrinology and metabolism |
| 34022841 | ALDH2 polymorphism rs671 is a predictor of PD-1/PD-L1 inhibitor efficacy against thoracic malignancies. | Matsumoto A et al. | 2021 | BMC cancer |
| 34033144 | Association between aldehyde dehydrogenase 2 gene rs671 G>A polymorphism and alcoholic liver cirrhosis in southern Chinese Hakka population. | Zeng D et al. | 2021 | Journal of clinical laboratory analysis |
| 34051793 | Association of ADH1B polymorphism and alcohol consumption with increased risk of intracerebral hemorrhagic stroke. | Lin CH et al. | 2021 | Journal of translational medicine |
| 34073884 | ALDH2 p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old. | Sasaki T et al. | 2021 | Genes |
| 34118567 | Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism. | Tsai MH et al. | 2021 | Stem cell research |
| 34211048 | Acetaldehyde exposure underlies functional defects in monocytes induced by excessive alcohol consumption. | Shiba S et al. | 2021 | Scientific reports |
| 34221859 | The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment. | Zhang H et al. | 2021 | Acta pharmaceutica Sinica. B |
| 34247200 | Associations between KCNQ1 and ITIH4 gene polymorphisms and infant weight gain in early life. | Zhang Y et al. | 2022 | Pediatric research |
| 34260573 | Interaction between ALDH2 rs671 and life habits affects the risk of hypertension in Koreans: A STROBE observational study. | Kim SS et al. | 2021 | Medicine |
| 34268385 | Analysis of gender-specific associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms and serum uric acid levels in Han Chinese. | Wu J et al. | 2021 | Annals of translational medicine |
| 34310648 | Combinations of alcohol-induced flushing with genetic polymorphisms of alcohol and aldehyde dehydrogenases and the risk of alcohol dependence in Japanese men and women. | Yokoyama A et al. | 2021 | PloS one |
| 34342185 | Association between Alcohol Consumption and Serum Cortisol Levels: a Mendelian Randomization Study. | Yang JH et al. | 2021 | Journal of Korean medical science |
| 34457340 | Relationship between rice farming and polygenic scores potentially linked to agriculture in China. | Zhu C et al. | 2021 | Royal Society open science |
| 34481002 | ALDH2, ADCY3 and BCMO1 polymorphisms and lifestyle-induced traits are jointly associated with CAD risk in Chinese Han people. | Ye CY et al. | 2022 | Gene |
| 34572589 | The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times. | Lin CL et al. | 2021 | Biomolecules |
| 34584183 | Genetic landscape of 125 pharmacogenes in Chinese from the Chinese Millionome Database. | Qi G et al. | 2021 | Scientific reports |
| 34593890 | Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition. | Cho YH et al. | 2021 | Scientific reports |
| 34626249 | Association between alcohol and bone mineral density in a Mendelian randomization study: the Dong-gu study. | Choi CK et al. | 2022 | Journal of bone and mineral metabolism |
| 34680127 | Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder. | Castaldelli-Maia JM et al. | 2021 | Biomolecules |
| 34680942 | Associations between ALDH Genetic Variants, Alcohol Consumption, and the Risk of Nasopharyngeal Carcinoma in an East Asian Population. | Liao WL et al. | 2021 | Genes |
| 34827557 | Variant Aldehyde Dehydrogenase 2 (ALDH2*2) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians. | Hung CL et al. | 2021 | Biomolecules |
| 35102643 | New insights into the genetic contribution of ALDH2 rs671 in pancreatic carcinogenesis: Evaluation by mediation analysis. | Koyanagi YN et al. | 2022 | Cancer science |
| 35129315 | Causal Association Between Alcohol Consumption and Atrial Fibrillation: A Mendelian Randomization Study. | Yang JH et al. | 2022 | Korean circulation journal |
| 35132194 | A genome-wide association study on adherence to low-carbohydrate diets in Japanese. | Nakamura Y et al. | 2022 | European journal of clinical nutrition |
| 35249931 | Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity. | Matsumoto E et al. | 2023 | Journal of atherosclerosis and thrombosis |
| 35309545 | The ALDH2 rs671 polymorphism is associated with athletic status and muscle strength in a Japanese population. | Kikuchi N et al. | 2022 | Biology of sport |
| 35318866 | Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. | Kasai A et al. | 2022 | American journal of physiology. Regulatory, integrative and comparative physiology |
| 35346052 | Association of ALDH2 rs671 and MTHFR rs1801133 polymorphisms with hypertension among Hakka people in Southern China. | Wu H et al. | 2022 | BMC cardiovascular disorders |
| 35368830 | Associations of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Polymorphism With Cognitive Impairment Among the Oldest-Old in China. | Jin X et al. | 2021 | Frontiers in aging neuroscience |
| 35393951 | Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression. | Li L et al. | 2022 | JCI insight |
| 35450031 | ALDH2 Polymorphism rs671 *1/*2 Genotype is a Risk Factor for the Development of Alcoholic Liver Cirrhosis in Hakka Alcoholics. | Chen Y et al. | 2022 | International journal of general medicine |
| 35501403 | Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans. | Yang W et al. | 2022 | Communications biology |
| 35568135 | Aldehyde dehydrogenase 2 and arrhythmogenesis. | Jin J et al. | 2022 | Heart rhythm |
| 35670037 | Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. | Chang TG et al. | 2023 | Cancer medicine |
| 35687413 | Causal associations of alcohol consumption with cardiovascular diseases and all-cause mortality among Chinese males. | Hu C et al. | 2022 | The American journal of clinical nutrition |
| 35877121 | Association of Heavy Alcohol Intake and ALDH2 rs671 Polymorphism With Hepatocellular Carcinoma and Mortality in Patients With Hepatitis B Virus-Related Cirrhosis. | Tsai MC et al. | 2022 | JAMA network open |
| 35891198 | Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population. | Matsumoto A et al. | 2022 | Vaccines |
| 35907253 | Alcohol consumption and subclinical and clinical coronary heart disease: a Mendelian randomization analysis. | Hisamatsu T et al. | 2022 | European journal of preventive cardiology |
| 36068255 | The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type. | Yoo MG et al. | 2022 | Scientific reports |
| 36079852 | Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China. | Cui Y et al. | 2022 | Nutrients |
Help
The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.
Genome context:
Select flank length:
Genomic regions, transcripts, and products
Top▲
Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.