Oxaliplatin
- PMID: 32491622
- Bookshelf ID: NBK557690
Oxaliplatin
Excerpt
Oxaliplatin is a medication used to manage and treat metastatic colorectal cancer. It is a member of the platinum-based chemotherapeutic class of drugs and is indicated in the adjunctive treatment of stage III colorectal cancer after resection of the primary tumor and for the treatment of metastatic colorectal cancer. It is FDA-approved in combination with infusional 5-fluorouracil and leucovorin. This activity reviews the indications, actions, and contraindications for oxaliplatin as a valuable agent in treating colorectal cancer and will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interaction) pertinent for members of the healthcare team in the treatment of patients with metastatic colorectal cancer and related conditions.
Copyright © 2025, StatPearls Publishing LLC.
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References
-
- Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med. 2005 Feb 03;352(5):476-87. - PubMed
-
- Noepel-Duennebacke S, Arnold D, Hertel J, Tannapfel A, Hinke A, Hegewisch-Becker S, Reinacher-Schick A. Impact of the Localization of the Primary Tumor and RAS/BRAF Mutational Status on Maintenance Strategies After First-line Oxaliplatin, Fluoropyrimidine, and Bevacizumab in Metastatic Colorectal Cancer: Results From the AIO 0207 Trial. Clin Colorectal Cancer. 2018 Dec;17(4):e733-e739. - PubMed
-
- Geoerger B, Chisholm J, Le Deley MC, Gentet JC, Zwaan CM, Dias N, Jaspan T, Mc Hugh K, Couanet D, Hain S, Devos A, Riccardi R, Cesare C, Boos J, Frappaz D, Leblond P, Aerts I, Vassal G, European Consortium Innovative Therapies for Children with Cancer (ITCC) Phase II study of gemcitabine combined with oxaliplatin in relapsed or refractory paediatric solid malignancies: An innovative therapy for children with Cancer European Consortium Study. Eur J Cancer. 2011 Jan;47(2):230-8. - PubMed
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