Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Filters applied. Clear filters
Book

Proton Pump Inhibitors (PPI)

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Proton Pump Inhibitors (PPI)

Abdelwahab Ahmed et al.
Free Books & Documents

Excerpt

Proton pump inhibitors represent a class of medications used to treat a wide variety of pathologies related to the stomach's acid production. This activity reviews the indications, action, contraindications for proton pump inhibitors as a valuable agent in managing acid-related disorders. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team in the treatment of acid-related disorders.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Abdelwahab Ahmed declares no relevant financial relationships with ineligible companies.

Disclosure: John Clarke declares no relevant financial relationships with ineligible companies.

Similar articles

  • Ustekinumab.
    Colquhoun M, Kemp AK. Colquhoun M, et al. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Mar 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 34033407 Free Books & Documents.
  • Reverse Transcriptase Inhibitors.
    Patel PH, Zulfiqar H. Patel PH, et al. 2023 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Jun 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31855348 Free Books & Documents.
  • Dexrazoxane.
    Eneh C, Lekkala MR. Eneh C, et al. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 Jul 17. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32809394 Free Books & Documents.
  • Cisplatin.
    Gold JM, Raja A. Gold JM, et al. 2023 May 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2023 May 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31613475 Free Books & Documents.
  • Proton pump inhibitors and cardiovascular risk: a critical review.
    Duarte GJ, Lopez J, Sosa F, Molina G, Shaban M, Mark J, Khizar A, Sreenivasan A, Tran A, Guerra MR. Duarte GJ, et al. Future Cardiol. 2024;20(14):779-794. doi: 10.1080/14796678.2024.2412910. Epub 2024 Oct 28. Future Cardiol. 2024. PMID: 39466134 Free PMC article. Review.

References

    1. Strand DS, Kim D, Peura DA. 25 Years of Proton Pump Inhibitors: A Comprehensive Review. Gut Liver. 2017 Jan 15;11(1):27-37. - PMC - PubMed
    1. Ward RM, Kearns GL. Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs. 2013 Apr;15(2):119-31. - PMC - PubMed
    1. El Rouby N, Lima JJ, Johnson JA. Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):447-460. - PMC - PubMed
    1. Modak AS, Klyarytska I, Kriviy V, Tsapyak T, Rabotyagova Y. The effect of proton pump inhibitors on the CYP2C19 enzyme activity evaluated by the pantoprazole-13C breath test in GERD patients: clinical relevance for personalized medicine. J Breath Res. 2016 Dec 17;10(4):046017. - PubMed
    1. Zhao S, Lv Y, Zhang JB, Wang B, Lv GJ, Ma XJ. Gastroretentive drug delivery systems for the treatment of Helicobacter pylori. World J Gastroenterol. 2014 Jul 28;20(28):9321-9. - PMC - PubMed

Publication types

LinkOut - more resources